2.1.1.35: tRNA (uracil54-C5)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (uracil54-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.35
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2.1.1.35
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histone
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h3k4me3
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trithorax
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trimethylation
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compass
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prdi-bf1
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molecular biology
- 2.1.1.35
- histone
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h3k4me3
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trithorax
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trimethylation
- compass
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prdi-bf1
- molecular biology
Reaction
Synonyms
5-methyluridine 54 tRNA methyltransferase, m5U 54 tRNA methyltransferase, m5U 54 tRNA MTase, m5U methyltransferase, m5U-methyltransferase, methyltransferase, transfer ribonucleate uracil 5-, PAB0719, PAB0719 enzyme, PabTrmU54, ribothymidyl synthase, rTase, RumA, RumA-type tRNA(uracil-54, C5)-methyltransferase, RUMT, S-adenosyl-L-methionine-dependent tRNA (uracil-54, C5)-methyltransferase, transfer RNA uracil 5-methyltransferase, transfer RNA uracil methylase, TrmA, TRMT2A, tRNA (uracil-54, C5)-methyltransferase, tRNA uracil 5-methyltransferase, tRNA(m5U54)methyltransferase, tRNA(uracil-5-)methyltransferase
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Natural Substrates Products
Natural Substrates Products on EC 2.1.1.35 - tRNA (uracil54-C5)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + tRNA containing uridine at position 54
S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
additional information
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the enzyme emerged through an ancient horizontal transfer of an RNA (uracil, C5)-methyltransferase-like gene from bacteria to archaea
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S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54
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?
S-adenosyl-L-methionine + tRNA containing uridine at position 54
S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54
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?
S-adenosyl-L-methionine + tRNA containing uridine at position 54
S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54
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?
S-adenosyl-L-methionine + tRNA containing uridine at position 54
S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54
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-
-
?
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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in vivo present both as 42 kDa polypeptide and as covalent TrmA/RNA complex, to equal amounts, both with methylating activity, in vivo the m5U54 modification confers a small selective growth advantage, two different catalytic activities: synthesis of m5U54 and an unknown essential function, may be associated with binding RNA, either during a maturation process of the rRNA and/or tRNA or as a regulatory device during the assembly and maturation of the translational apparatus such as an RNA chaperone
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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specific reaction in maturation of tRNA
ribothymidine is the most common methylated nucleoside found in tRNA, it occurs in all tRNAs of the organism
?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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enzyme-tRNA complexes may exist as dihydrouridine intermediates and may serve as reservoirs of RUMT-tRNA complexes primed for methylation
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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involved in biosynthesis of all tRNA chains, association of enzyme to tRNA may be of regulatory significance
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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specific inhibition of enzyme by ethionine in vivo
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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primary function of nucleoside modification within the tRNA anticodon loop is to negate potential canonical base pairs that would close the loop and, thereby, hinder codon binding
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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in vivo present both as 42 kDa polypeptide and as covalent TrmA/RNA complex, to equal amounts, both with methylating activity, in vivo the m5U54 modification confers a small selective growth advantage, two different catalytic activities: synthesis of m5U54 and an unknown essential function, may be associated with binding RNA, either during a maturation process of the rRNA and/or tRNA or as a regulatory device during the assembly and maturation of the translational apparatus such as an RNA chaperone
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
Escherichia coli C600 / pTN106
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
Escherichia coli C600 / pTN106
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involved in biosynthesis of all tRNA chains, association of enzyme to tRNA may be of regulatory significance
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
Escherichia coli GB-1-5-39 / pTN102
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
-
specific reaction in maturation of tRNA
ribothymidine is the most common methylated nucleoside found in tRNA, it occurs in all tRNAs of the organism
?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
-
tRNA modifying enzyme
-
?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
-
tRNA modifying enzyme
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?
S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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enzyme is responsible for the formation of 5-methyluridine at position 54 in tRNA
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S-adenosyl-L-methionine + uridine54 in tRNA
S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
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role per se in tRNA maturation, stabilization of tRNA, early event in tRNA maturation: intron-containing pre-tRNAs contain m5U
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?