1.14.99.58: heme oxygenase (biliverdin-IX-beta and delta-forming)
This is an abbreviated version!
For detailed information about heme oxygenase (biliverdin-IX-beta and delta-forming), go to the full flat file.
Reaction
Synonyms
biliverdin IXbeta/delta-selective heme oxygenase, BphO, heme-PigA heme oxygenase, heme-PigA(HO), HemO, PigA
ECTree
1.14.99.58 heme oxygenase (biliverdin-IX-beta and delta-forming)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.14.99.58 - heme oxygenase (biliverdin-IX-beta and delta-forming)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
heme + electron donor + O2
alpha-biliverdin + beta-biliverdin + delta-biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
-
wild-type, mutant N19K, mutant F117Y, 30% beta- and 70% delta-isomer, N19K/F117Y double mutant, 55% alpha-, 10% beta-, 35% delta-isoform
-
?
heme + electron donor + O2
biliverdin IXalpha + Fe2+ + CO + oxidized eletron donor + H2O
-
prefers ferredoxin or ascorbate as electron donor
-
-
?
protoheme + reduced acceptor + O2
biliverdin-IX-beta + CO + Fe2+ + acceptor + H2O
-
-
-
-
?
protoheme + reduced acceptor + O2
biliverdin-IX-delta + CO + Fe2+ + acceptor + H2O
-
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
natural electron donor for PigA from Pseudomonas aeruginosa PAO1 is ferredoxin-NADP+-oxidoreductase
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ferredoxin from spinach, and spinach ferredoxin-NADP+-oxidoreductase
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
Pseudomonas aeruginosa KT 2240
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
-
-
?
heme + 3 AH2 + 3 O2
biliverdin + Fe2+ + CO + 3 A + 3 H2O
with NADPH, ascorbate, FNR and ferredoxin as exogenous reductant system, spectroscopic determination
-
-
?
additional information
?
-
-
BphO, a heme oxygenase, produces the linear tetrapyrrole chromophore biliverdin IXa, potential protective role of the BphO reaction product biliverdin, overview
-
-
?
additional information
?
-
the organism contains only one enzyme type: PigA. PigA produces the biliverdin isomer IXalpha
-
-
?
additional information
?
-
the organism contains only one enzyme type: PigA. PigA produces the biliverdin isomer IXalpha
-
-
?
additional information
?
-
the organism contains only one enzyme type: PigA. PigA produces the biliverdin isomer IXalpha
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
Pseudomonas aeruginosa KT 2240
the organism contains only one enzyme type: PigA. PigA produces the biliverdin isomer IXalpha
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains only one enzyme type: PigA. PigA produces the biliverdin isomer IXalpha
-
-
?
additional information
?
-
the organism contains only one enzyme type: PigA. PigA produces the biliverdin isomer IXalpha
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
additional information
?
-
the organism contains two heme oxygenases with different regiospecificities: BphO and PigA. While BphO cleaves heme to exclusively yield biliverdin IXalpha, PigA produces the biliverdin isomers IXbeta and IXdelta
-
-
?
