1.14.99.58: heme oxygenase (biliverdin-IX-beta and delta-forming)

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For detailed information about heme oxygenase (biliverdin-IX-beta and delta-forming), go to the full flat file.

Reaction

Synonyms

biliverdin IXbeta/delta-selective heme oxygenase, BphO, heme-PigA heme oxygenase, heme-PigA(HO), HemO, PigA

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.99 Miscellaneous

                1.14.99.58 heme oxygenase (biliverdin-IX-beta and delta-forming)

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Results	in table
1	Activating Compound
17	AA Sequence
1	Application
16	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
1	General Information
13	Inhibitors
6	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
29	Organism
3	Pathway
3	pH Optimum
5	pH Range
1	Posttranslational Modification
19	Protein Variants
11	Purification (Commentary)
4	Reaction
29	Reference
44	Substrates and Products (Substrate)
3	Subunits
28	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 1.14.99.58 - heme oxygenase (biliverdin-IX-beta and delta-forming)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(2E)-2-[4-(dimethylamino)benzylidene]hydrazinecarboximidamide

Pseudomonas aeruginosa

-

binding affinity 0.030 mM

681311

(2E)-2-[[4-(dimethylamino)phenyl]methylidene]hydrazinecarboximidamide

Pseudomonas aeruginosa

-

binding affinity is 0.030 mM, complete inhibition

681311

(2Z)-4-[(4-anilinophenyl)amino]-4-oxobut-2-enoic acid

Pseudomonas aeruginosa

-

binding affinity 0.0201 mM, above 0.25 mM significant decrease in growth of strain on heme as sole source of iron

681311

(2Z)-N'-[(1Z)-pyridin-3-ylmethylene]-2-(pyridin-3-ylmethylene)hydrazinecarboximidohydrazide

Pseudomonas aeruginosa

-

binding affinity 0.0159 mM

681311

(2Z)-N'-[(1Z)-pyridin-3-ylmethylidene]-2-(pyridin-3-ylmethylidene)hydrazinecarboximidohydrazide

Pseudomonas aeruginosa

-

binding affinity is 0.0159 mM, complete inhibition

681311

1-(2,4-dinitrophenyl)methanamine

Pseudomonas aeruginosa

-

binding affinity 0.187 mM

681311

2-(4-chlorophenyl)-N'-[(1E)-1H-indol-3-ylmethylidene]acetohydrazide

Pseudomonas aeruginosa

-

binding affinity is 0.0158 mM, complete inhibition

681311

2-(4-chlorophenyl)-N'-[(1Z)-1H-inden-3-ylmethylene]acetohydrazide

Pseudomonas aeruginosa

-

binding affinity 0.0158 mM, above 0.25 mM significant decrease in growth of strain on heme as sole source of iron

681311

4-oxo-4-[[4-(phenylamino)phenyl]amino]butanoic acid

Pseudomonas aeruginosa

-

binding affinity is 0.0201 mM, complete inhibition

681311

4-[(2-hydroxyphenyl)amino]naphthalene-1,2-dione

Pseudomonas aeruginosa

-

binding affinity is 0.0728 mM, partial inhibition

681311

N'-(pyridin-4-ylcarbonyl)pyridine-4-carbohydrazide

Pseudomonas aeruginosa

-

binding affinity is 0.0447 mM, partial inhibition

681311

N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-2-nitrobenzamide

Pseudomonas aeruginosa

-

binding affinity is 0.0061 mM, complete inhibition

681311

N-(4-imidazo[1,2-a]pyridin-2-ylphenyl)-3-nitrobenzamide

Pseudomonas aeruginosa

-

binding affinity 0.0061 mM

681311