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1.14.19.18: sphingolipid 8-(E)-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 8-(E)-desaturase, go to the full flat file.

Reaction

a (4E)-sphing-4-enine ceramide
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
a (4E,8E)-sphing-4,8-dienine ceramide
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8-sphingolipid desaturase, DesB, SLD, sphinganine DELTA8-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.18 sphingolipid 8-(E)-desaturase

Cloned

Cloned on EC 1.14.19.18 - sphingolipid 8-(E)-desaturase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae strain InvSc1
expressed in Saccharomyces cerevisiae, Arabidopsis thaliana, and Nicotiana benthamiana
mutant enzymes are expressed in Saccharomyces cerevisae strain INVScI