1.14.19.18: sphingolipid 8-(E)-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 8-(E)-desaturase, go to the full flat file.

+ 2 ferrocytochrome b5 +

+ 2 H+ =

+ 2 ferricytochrome b5 + 2 H2O

8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8-sphingolipid desaturase, DesB, SLD, sphinganine DELTA8-desaturase

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Results	in table
1705	AA Sequence
7	Cloned(Commentary)
8	Cofactor
5	General Information
3	Localization
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
14	Organism
15	Protein Variants
1	Reaction
13	Reference
2	Source Tissue
12	Substrates and Products (Substrate)
8	Subunits
29	Synonyms
1	Systematic Name

Substrates Products on EC 1.14.19.18 - sphingolipid 8-(E)-desaturase

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(4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+

(4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O

4-hydroxysphinganine + ferrocytochrome b5 + O2 + H+

4-hydroxy-trans-8-sphingenine + ferricytochrome b5 + H2O

C18-phytosphingenine + ferrocytochrome b5 + O2 + H+

(8Z)-C18-phytosphingenine + (8E)-C18-phytosphingenine + ferricytochrome b5 + H2O

C18-phytosphingosine + ferrocytochrome b5 + O2 + H+

(8Z)-C18-phytosphingenine + (8E)-C18-phytosphingenine + ferricytochrome b5 + H2O

sphinganine + ferrocytochrome b5 + O2 + H+

the enzyme shows strong preference for dihydroxylated substrates

additional information