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1.14.19.18: sphingolipid 8-(E)-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 8-(E)-desaturase, go to the full flat file.

Reaction

a (4E)-sphing-4-enine ceramide
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
a (4E,8E)-sphing-4,8-dienine ceramide
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8-sphingolipid desaturase, DesB, SLD, sphinganine DELTA8-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.18 sphingolipid 8-(E)-desaturase

Engineering

Engineering on EC 1.14.19.18 - sphingolipid 8-(E)-desaturase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F59R
the mutant shows markedly decreased conversion rate compared to the wild type enzyme
G28R
the mutant shows slightly decreased conversion rate compared to the wild type enzyme
G52R
the mutant shows wild type activity
L369A
the mutant shows markedly decreased conversion rate compared to the wild type enzyme
L71R
the mutant shows wild type activity
Q372H
the mutant shows markedly decreased conversion rate compared to the wild type enzyme
T56R
the mutant shows slightly decreased conversion rate compared to the wild type enzyme
W190A
the mutant shows markedly decreased conversion rate compared to the wild type enzyme
W345A
the mutant shows markedly decreased conversion rate compared to the wild type enzyme
Y31A
the mutant shows slightly decreased conversion rate compared to the wild type enzyme