1.1.1.136: UDP-N-acetylglucosamine 6-dehydrogenase

This is an abbreviated version, for detailed information about UDP-N-acetylglucosamine 6-dehydrogenase, go to the full flat file.

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+ 2 NAD+ +
H2O
=
UDP-2-acetamido-2-deoxy-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

dehydrogenase, uridine diphosphoacetylglucosamine, gnaA, O180 O antigen, TviB, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, UDP-GlcNAc 6-dehydrogenase, UDP-GlcNAc dehydrogenase, UDP-N-acetylglucosamine C-6 dehydrogenase, UDPacetylglucosamine dehydrogenase, UGlcNAcDH, uridine 5'-diphosphate-N-acetyl-D-glucosamine oxidoreductase, uridine diphosphoacetylglucosamine dehydrogenase, WbpA

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.136 UDP-N-acetylglucosamine 6-dehydrogenase

Systematic Name

Systematic Name on EC 1.1.1.136 - UDP-N-acetylglucosamine 6-dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-alpha-D-glucosamine:NAD+ 6-oxidoreductase
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.