1.1.1.136: UDP-N-acetylglucosamine 6-dehydrogenase

This is an abbreviated version, for detailed information about UDP-N-acetylglucosamine 6-dehydrogenase, go to the full flat file.

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+ 2 NAD+ +
H2O
=
UDP-2-acetamido-2-deoxy-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

dehydrogenase, uridine diphosphoacetylglucosamine, gnaA, O180 O antigen, TviB, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, UDP-GlcNAc 6-dehydrogenase, UDP-GlcNAc dehydrogenase, UDP-N-acetylglucosamine C-6 dehydrogenase, UDPacetylglucosamine dehydrogenase, UGlcNAcDH, uridine 5'-diphosphate-N-acetyl-D-glucosamine oxidoreductase, uridine diphosphoacetylglucosamine dehydrogenase, WbpA

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.136 UDP-N-acetylglucosamine 6-dehydrogenase

KM Value

KM Value on EC 1.1.1.136 - UDP-N-acetylglucosamine 6-dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.276 - 4.16
NAD+
0.077 - 0.84
UDP-N-acetyl-D-glucosamine
additional information
additional information
-
positive cooperativity with respect to substrate binding, Hill coefficient 1.8
-