1.1.1.136: UDP-N-acetylglucosamine 6-dehydrogenase

This is an abbreviated version, for detailed information about UDP-N-acetylglucosamine 6-dehydrogenase, go to the full flat file.

Reaction

UDP-N-acetyl-alpha-D-glucosamine
+ 2 NAD+ +
H2O
=
UDP-2-acetamido-2-deoxy-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

dehydrogenase, uridine diphosphoacetylglucosamine, gnaA, O180 O antigen, TviB, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, UDP-GlcNAc 6-dehydrogenase, UDP-GlcNAc dehydrogenase, UDP-N-acetylglucosamine C-6 dehydrogenase, UDPacetylglucosamine dehydrogenase, UGlcNAcDH, uridine 5'-diphosphate-N-acetyl-D-glucosamine oxidoreductase, uridine diphosphoacetylglucosamine dehydrogenase, WbpA

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.136 UDP-N-acetylglucosamine 6-dehydrogenase

Purification

Purification on EC 1.1.1.136 - UDP-N-acetylglucosamine 6-dehydrogenase

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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant C-terminally His6-tagged TviB from Escherichia coli strain BL21(DE3) by two steps of anion exchange chromatography, affinity chromatography, and gel filtration, inactive oligomeric forms of the enzym eis removed in gel filtration, to near homogeneity
-
recombinant protein with His-tag
-