Sequence of NEC2_CAEEL
EC Number:3.4.21.94
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds
Other sequences found for EC No. 3.4.21.94
General information:
Sequence
0 MKNTHVDLIC VFLSIFIGIG EAVDVYTNHF HVHLKEGGGL EDAHRIAKRH GFINRGQVAA
60 SDNEYHFVQP ALVHARTRRS AGHHAKLHND DEVLHVEQLK GYTRTKRGYR PLEQRLESQF
120 DFSAVMSPSD PLYGYQWYLK NTGQAGGKAR LDLNVERAWA MGFTGKNITT AIMDDGVDYM
180 HPDIKNNFNA EASYDFSSND PFPYPRYTDD WFNSHGTRCA GEIVAARDNG VCGVGVAYDG
240 KVAGIRMLDQ PYMTDLIEAN SMGHEPSKIH IYSASWGPTD DGKTVDGPRN ATMRAIVRGV
300 NEGRNGLGSI FVWASGDGGE DDDCNCDGYA ASMWTISINS AINNGENAHY DESCSSTLAS
360 TFSNGGRNPE TGVATTDLYG RCTRSHSGTS AAAPEAAGVF ALALEANPSL TWRDLQHLTV
420 LTSSRNSLFD GRCRDFPSLG INDNHRDSHG NCSHFEWQMN GVGLEYNHLF GFGVLDAAEM
480 VMLAMAWKTS PPRYHCTAGL IDTPHEIPAD GNLILEINTD GCAGSQFEVR YLEHVQAVVS
540 FNSTRRGDTT LYLISPMGTR TMILSRRPKD DDSKDGFTNW PFMTTHTWGE NPTGKWRLVA
600 RFQGPGAHAG TLKKFELMLH GTREAPYNLI EPIVGQTNKK LDTVQKAHKR SH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
448773
Gomez-Saladin E.,Wilson D.L.,Dickerson I.M.
Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans.
Cell. Mol. Neurobiol.
14
9-25
1994
448774
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science
282
2012-2018
1998
448775
Trent C.,Tsuing N.,Horvitz H.R.
Egg-laying defective mutants of the nematode Caenorhabditis elegans.
Genetics
104
619-647
1983
448776
Kass J.,Jacob T.C.,Kim P.,Kaplan J.M.
The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans.
J. Neurosci.
21
9265-9272
2001
448777
Jacob T.C.,Kaplan J.M.
The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions.
J. Neurosci.
23
2122-2130
2003
448778
Zahn T.R.,Angleson J.K.,MacMorris M.A.,Domke E.,Hutton J.F.,Schwartz C.,Hutton J.C.
Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.
Traffic
5
544-559
2004
448779
Husson S.J.,Clynen E.,Baggerman G.,Janssen T.,Schoofs L.
Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.
J. Neurochem.
98
1999-2012
2006
448780
Husson S.J.,Janssen T.,Baggerman G.,Bogert B.,Kahn-Kirby A.H.,Ashrafi K.,Schoofs L.
Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.
J. Neurochem.
102
246-260
2007
448781
Liu T.,Kim K.,Li C.,Barr M.M.
FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.
J. Neurosci.
27
7174-7182
2007
448782
Hung W.L.,Hwang C.,Gao S.,Liao E.H.,Chitturi J.,Wang Y.,Li H.,Stigloher C.,Bessereau J.L.,Zhen M.
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
EMBO J.
32
1745-1760
2013
448783
Stawicki T.M.,Takayanagi-Kiya S.,Zhou K.,Jin Y.
Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans.
PLoS Genet.
9
0-0
2013
448784
Hung W.L.,Wang Y.,Chitturi J.,Zhen M.
A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.
Development
141
1767-1779
2014
