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2-aminobenzoyl-LPSDEEGESYKEVPEMEKRYGGFMQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
2-aminobenzoyl-LPSDEEGESYKEVPEMEKR + YGGFMQ-N-(2,4-dinitrophenyl)ethylenediamine
-
-
-
?
2-aminobenzoyl-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
2-aminobenzoyl-Val-Pro-Arg-Met-Glu-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Gln-N-(2,4-dinitrophenyl)ethylenediamine + H2O
?
-
-
-
?
Ac-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide + H2O
Ac-Arg-Phe-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Ac-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide + H2O
Ac-Arg-Pro-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Ac-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
Ac-Lys-Ser-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Ac-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
Ac-Orn-Ser-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Boc-Gly-Arg-Arg-4-methylcoumarin 7-amide + H2O
Boc-Gly-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Boc-Gly-Lys-Arg-4-methylcoumarin 7-amide + H2O
Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide + H2O
Boc-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
?
CBZ-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide + H2O
CBZ-Arg-Ser-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Cbz-Arg-Ser-Lys-Arg-aminomethylcoumarin + H2O
?
-
-
-
?
cholecystokinin 8-containing peptide + H2O
?
-
a synthetic peptide substrate containing the CCK 8 Gly Arg Arg peptide sequence, i.e. DYMGWMDF, and the cleavage site of pro-cholecystokinin for its liberation, overview
-
-
?
dynorphin A 1-17 + H2O
?
-
-
-
?
dynorphin AB 1-32 + H2O
?
-
-
-
?
dynorphin-A(1-8) + H2O
?
-
-
-
-
?
glicentin1-69 + H2O
glucagon + glicentin-related polypeptide + GLP-1
-
glicentin lacks the signal sequence of proglucagon, residues -20-1, recombinant hamster substrate and murine enzyme co-expressed in rat GH4C1 cells, cleavage at the proglucagon interdomain site Lys70-Arg71-/-, at Lys31-Arg32-/-, and at -/-Lys62-Arg63
mature glucagon consists of residues 33-61, glicentin-related polypeptide comprises the C-terminal residues 1-32, GLP-1 is the N-terminal glucagon-like peptide comprising residues 62-69
-
?
L-pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O
L-pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
leumorphin + H2O
?
-
-
-
?
peptide B-derived peptides + H2O
?
-
cleavage site specificity of wild-type and mutant PC2, overview
-
-
?
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
pro-cholecystokinin + H2O
N-terminal propeptide + C-terminal cholecystokinin 8 Gly Arg Arg peptide + remaining CCK peptide
-
the substrate is only cleaved in vivo since defolding proteins are required, in vitro the cleavage site is inaccessible for the enzyme
peptide product analysis
-
?
pro-cholecystokinin + H2O
N-terminal propeptide + cholecystokinin 58
-
the substrate is only cleaved at the CKK 8 peptide in vivo since defolding proteins are required, in vitro the cleavage site is inaccessible for the enzyme
peptide product analysis
-
?
pro-islet amyloid polypeptide + H2O
islet amyloid polypeptide processing intermediate + N-terminal pro-peptide
-
precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the N-terminus, but not the C-terminus, which would also be required for activation, the complete activation is catalyzed by PC1, EC 3.4.21.93
-
-
?
pro-neurotensin/neuromedin N + H2O
neurotensin + neuromedin N
Pro-opiomelanocortin + H2O
Opiomelanocortin + ?
-
from mouse and pig
-
-
?
prodynorphin + H2O
dynorphin + ?
prodynorphin + H2O
dynorphin A 1-17 + dynorphin B 1-13 + alpha-neo-endorphin + C-peptide + dynorphin A 1-8 + ?
-
-
-
?
Proenkephalin + H2O
Enkephalin + ?
-
human
-
-
?
proenkephalin + H2O
opioid-active enkephalin + ?
proenkphalin-derived peptide + H2O
?
-
the preferred cleavage site sequence of PC2 is YGGFLKR-/-FAESL
-
-
?
proglucagon + H2O
glucagon
-
-
-
-
?
Proglucagon + H2O
Glucagon + ?
-
dibasic cleavage sites
-
?
proglucagon1-158 + H2O
glucagon + glicentin-related polypeptide + GLP-1 + IP2/GLP-2
-
recombinant hamster substrate and murine enzyme co-expressed in rat GH4C1 cells, cleavage at the proglucagon interdomain site Lys70-Arg71-/-, at Lys31-Arg32-/-, and at -/-Lys62-Arg63
mature glucagon consists of residues 33-61, glicentin-related polypeptide comprises the C-terminal residues 1-32, GLP-1 is the N-terminal glucagon-like peptide comprising residues 62-69, IP2/GLP-2 comprises residues 72-158
-
?
proIAPP + H2O
mature IAPP
-
enhanced NH(2)-terminal processing of proIAPP by adenoviral expression of PC2, reducing (pro)IAPP-induced cell death in GH3 cells. Overexpression of PC2 in INS-1 beta-cells also enhances NH(2)-terminal processing of proIAPP
-
-
?
Proinsulin + H2O
Insulin + ?
-
selective cleavage only at the C peptide-A chain junction
-
-
?
proPC2 + H2O
mature PC2
-
-
-
-
?
proSAAS + H2O
little-LEN + ?
-
-
-
?
prothyrotropin-releasing hormone + H2O
thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
pyr-Glu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
somatostatin + H2O
?
-
PC2 may function as sorting element for somatostatin for its maturation and processing to appropiate targets
-
-
?
additional information
?
-
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
pGlu-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O
pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
?
pro-neurotensin/neuromedin N + H2O
neurotensin + neuromedin N
-
-
-
-
?
pro-neurotensin/neuromedin N + H2O
neurotensin + neuromedin N
-
-
-
-
?
pro-neurotensin/neuromedin N + H2O
neurotensin + neuromedin N
-
-
-
-
?
prodynorphin + H2O
dynorphin + ?
-
rat
-
-
?
prodynorphin + H2O
dynorphin + ?
-
cleavage at a single Arg residue
-
-
?
prodynorphin + H2O
dynorphin + ?
-
at a bond in which P2 is Thr
-
-
?
proenkephalin + H2O
opioid-active enkephalin + ?
-
-
-
?
proenkephalin + H2O
opioid-active enkephalin + ?
-
-
-
?
proenkephalin + H2O
opioid-active enkephalin + ?
-
cleaves prohormones and proneuropeptides from inactive large precursors to generate activre peptide for extracellular release
-
?
Proglucagon + H2O
?
-
key endoprotease responsible for proglucagon processing in cells with the alpha-cell phenotype
-
-
?
Proglucagon + H2O
?
-
-
-
-
?
prothyrotropin-releasing hormone + H2O
thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview
-
-
?
prothyrotropin-releasing hormone + H2O
thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
-
processing of the prohormone
-
-
?
additional information
?
-
-
EGL-3/KPC2 is required for processing of FMRFamide-like peptide precursors and neuropeptide-like protein precursors
-
-
?
additional information
?
-
-
EGL-3/KPC2 is required for processing of FMRFamide-like peptide precursors and neuropeptide-like protein precursors
-
-
?
additional information
?
-
-
cleavage specificity, cleaves precursors both at specific single and pairs of basic residues, not: prorenin, prosomatostatin
-
-
?
additional information
?
-
-
processing of precursors that are routed toward secretory granules
-
-
?
additional information
?
-
-
proprotein convertases play a major role in liver metastasis
-
-
?
additional information
?
-
-
PC2 may be important in insulin and glucagon cells for processing of hormone and other protein precursors
-
-
?
additional information
?
-
-
present on secretory pathway of neuroendocrine cells
-
-
?
additional information
?
-
-
prefers Arg at positions P4 and P5 in peptide B IQ substrates, Boc-Val-Leu-Lys-4-methylcoumarin 7-amide is no substrate
-
?
additional information
?
-
-
glucose-dependent insulinotropic polypeptide precursor is no substrate of PC2
-
-
?
additional information
?
-
-
cleavage site specificity, activity with mutant proglucagon and truncation variants, analysis of importance of substrate domain structure, molecular modeling, overview
-
-
?
additional information
?
-
-
sequences with a Trp, Tyr and/or Pro in the P1' or P2' position, or a basic residue in the P3 position, are preferentially cleaved by PC2
-
-
?
additional information
?
-
enzyme binds hyperglycemic hormone that plays an important role in glucose metabolism and likely converts pro-CHH1 into a mature neuroendocrine hormone
-
-
?
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Adenoma
TFF3-Based Candidate Gene Discrimination of Benign and Malignant Thyroid Tumors in a Region with Borderline Iodine Deficiency.
Brain Injuries
Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains.
Brain Ischemia
Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains.
Carcinogenesis
Islets of Langerhans from prohormone convertase-2 knockout mice show ?-cell hyperplasia and tumorigenesis with elevated ?-cell neogenesis.
Carcinoid Tumor
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Carcinoma
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
Carcinoma
TFF3-Based Candidate Gene Discrimination of Benign and Malignant Thyroid Tumors in a Region with Borderline Iodine Deficiency.
Carcinoma, Papillary
Gene profiling identifies genes specific for well-differentiated epithelial thyroid tumors.
Carcinoma, Papillary
TFF3-Based Candidate Gene Discrimination of Benign and Malignant Thyroid Tumors in a Region with Borderline Iodine Deficiency.
Diabetes Mellitus
Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.
Diabetes Mellitus, Type 2
Association of the prohormone convertase 2 gene (PCSK2) on chromosome 20 with NIDDM in Japanese subjects.
Diabetes Mellitus, Type 2
Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population.
Diabetes Mellitus, Type 2
Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.
Diabetes Mellitus, Type 2
Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
Diabetes Mellitus, Type 2
Enteroendocrine K and L cells in healthy and type 2 diabetic individuals.
Diabetes Mellitus, Type 2
Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.
Diabetes Mellitus, Type 2
Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population.
Hyperglycemia
Cellular responses of novel human pancreatic ?-cell line, 1.1B4 to hyperglycemia.
Myocardial Infarction
Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals.
Neoplasm Metastasis
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Neoplasms
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
Neoplasms
Does the 3-gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?
Neoplasms
Gene profiling identifies genes specific for well-differentiated epithelial thyroid tumors.
Neoplasms
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Neoplasms
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
Neuroendocrine Tumors
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Paraganglioma
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Pheochromocytoma
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
proprotein convertase 2 deficiency
Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain.
Thyroid Nodule
TFF3-Based Candidate Gene Discrimination of Benign and Malignant Thyroid Tumors in a Region with Borderline Iodine Deficiency.
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Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
Homo sapiens
brenda
Seidah, N.G.; Chretien, M.
Pro-protein convertases of subtilisin/kexin family
Methods Enzymol.
244
175-188
1994
Homo sapiens
brenda
Rouille, Y.; Westermark, G.; Martin, S.K.; Steiner, D.F.
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells
Proc. Natl. Acad. Sci. USA
91
3242-3246
1994
Mammalia
brenda
Smeekens, S.P.; Steiner, D.F.
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
J. Biol. Chem.
265
2997-3000
1990
Homo sapiens
brenda
Cornwall, G.A.; Cameron, A.; Lindberg, I.; Hardy, D.M.; Cormier, N.; Hsia, N.
The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2
Endocrinology
144
901-908
2003
Mus musculus
brenda
Johanning, K.; Juliano, M.A.; Juliano, L.; Lazure, C.; Lamango, N.S.; Steiner, D.F.; Lindberg, I.
Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates
J. Biol. Chem.
273
22672-22680
1998
Mus musculus
brenda
Day, R.; Lazure, C.; Basak, A.; Boudreault, A.; Limperis, P.; Dong, W.; Lindberg, I.
Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
J. Biol. Chem.
273
829-836
1998
Mus musculus, Rattus norvegicus
brenda
Apletalina, E.V.; Muller, L.; Lindberg, I.
Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide
J. Biol. Chem.
275
14667-14677
2000
Mus musculus
brenda
Li, Q.L.; Naqvi, S.; Shen, X.; Liu, Y.J.; Lindberg, I.; Friedman, T.C.
Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues
Regul. Pept.
110
197-205
2003
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Tzimas, G.N.; Chevet, E.; Jenna, S.; Nguyen, D.T.; Khatib, A.M.; Marcus, V.; Zhang, Y.; Chretien, M.; Seidah, N.; Metrakos, P.
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases
BMC Cancer
5
149
2005
Homo sapiens
brenda
Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide
Diabetes
53
141-148
2004
Mus musculus
brenda
Dey, A.; Lipkind, G.M.; Rouille, Y.; Norrbom, C.; Stein, J.; Zhang, C.; Carroll, R.; Steiner, D.F.
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon
Endocrinology
146
713-727
2005
Mus musculus
brenda
Ogiwara, K.; Shinohara, M.; Takahashi, T.
Expression of proprotein convertase 2 mRNA in the ovarian follicles of the medaka, Oryzias latipes
Gene
337
79-89
2004
Oryzias latipes
brenda
Kacprzak, M.M.; Than, M.E.; Juliano, L.; Juliano, M.A.; Bode, W.; Lindberg, I.
Mutations of the PC2 substrate binding pocket alter enzyme specificity
J. Biol. Chem.
280
31850-31858
2005
Mus musculus
brenda
Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
J. Biol. Chem.
281
11050-11057
2006
Mus musculus
brenda
Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone
J. Clin. Invest.
114
357-369
2004
Rattus norvegicus
brenda
Henrich, S.; Lindberg, I.; Bode, W.; Than, M.E.
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
J. Mol. Biol.
345
211-227
2004
Homo sapiens
brenda
Tagen, M.B.; Beinfeld, M.C.
Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
Peptides
26
2530-2535
2005
Mus musculus
brenda
Lee, S.N.; Kacprzak, M.M.; Day, R.; Lindberg, I.
Processing and trafficking of a prohormone convertase 2 active site mutant
Biochem. Biophys. Res. Commun.
355
825-829
2007
Mus musculus
brenda
Portela-Gomes, G.M.; Grimelius, L.; Stridsberg, M.
Prohormone convertases 1/3, 2, furin and protein 7B2 (Secretogranin V) in endocrine cells of the human pancreas
Regul. Pept.
146
117-124
2008
Homo sapiens
brenda
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
brenda
Marzban, L.; Rhodes, C.J.; Steiner, D.F.; Haataja, L.; Halban, P.A.; Verchere, C.B.
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death
Diabetes
55
2192-2201
2006
Mus musculus
brenda
Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
Diabetes
56
2744-2752
2007
Mus musculus
brenda
Kitabgi, P.
Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines
J. Mol. Med.
84
628-634
2006
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Pan, H.; Che, F.Y.; Peng, B.; Steiner, D.F.; Pintar, J.E.; Fricker, L.D.
The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study
J. Neurochem.
98
1763-1777
2006
Mus musculus
brenda
Husson, S.J.; Clynen, E.; Baggerman, G.; Janssen, T.; Schoofs, L.
Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry
J. Neurochem.
98
1999-2012
2006
Caenorhabditis elegans, Caenorhabditis elegans N2
brenda
Leak, T.S.; Keene, K.L.; Langefeld, C.D.; Gallagher, C.J.; Mychaleckyj, J.C.; Freedman, B.I.; Bowden, D.W.; Rich, S.S.; Sale, M.M.
Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population
Mol. Genet. Metab.
92
145-150
2007
Homo sapiens
brenda
Croissandeau, G.; Wahnon, F.; Yashpal, K.; Seidah, N.G.; Coderre, T.J.; Chretien, M.; Mbikay, M.
Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2
Neurosci. Lett.
406
71-75
2006
Mus musculus
brenda
Marandi, M.; Mowla, S.J.; Tavallaei, M.; Yaghoobi, M.M.; Jafarnejad, S.M.
Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs)
Neurosci. Lett.
420
198-203
2007
Rattus norvegicus
brenda
Kowalska, D.; Liu, J.; Appel, J.R.; Ozawa, A.; Nefzi, A.; Mackin, R.B.; Houghten, R.A.; Lindberg, I.
Synthetic small-molecule prohormone convertase 2 inhibitors
Mol. Pharmacol.
75
617-625
2009
Mus musculus
brenda
Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction
Neuroscience
156
788-799
2008
Rattus norvegicus
brenda
Cummins, S.F.; York, P.S.; Hanna, P.H.; Degnan, B.M.; Croll, R.P.
Expression of prohormone convertase 2 and the generation of neuropeptides in the developing nervous system of the gastropod Haliotis
Int. J. Dev. Biol.
53
1081-1088
2009
Haliotis asinina (B2ZSS9), Haliotis asinina
brenda
Zhan, S.; Zhao, H.; J White, A.; Minami, M.; Pignataro, G.; Yang, T.; Zhu, X.; Lan, J.; Xiong, Z.; Steiner, D.F.; Simon, R.P.; Zhou, A.
Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains
J. Cereb. Blood Flow Metab.
29
698-706
2009
Rattus norvegicus
brenda
Zhang, X.; Pan, H.; Peng, B.; Steiner, D.F.; Pintar, J.E.; Fricker, L.D.
Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis
J. Neurochem.
112
1168-1179
2010
Mus musculus
brenda
Tang, S.S.; Zhang, J.H.; Liu, H.X.; Zhou, D.; Qi, R.
Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia
Neurosci. Bull.
25
7-14
2009
Rattus norvegicus
brenda
Helwig, M.; Lee, S.N.; Hwang, J.R.; Ozawa, A.; Medrano, J.F.; Lindberg, I.
Dynamic modulation of PC2-mediated precursor processing by 7B2: preferential effect on glucagon synthesis
J. Biol. Chem.
286
42504-42513
2011
Mus musculus
brenda
Iino, K.; Oki, Y.; Yamashita, M.; Matsushita, F.; Hayashi, C.; Yogo, K.; Nishizawa, S.; Yamada, S.; Maekawa, M.; Sasano, H.; Nakamura, H.
Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma
J. Clin. Endocrinol. Metab.
95
4003-4011
2010
Homo sapiens
brenda
Hiramoto, K.; Yamate, Y.; Kobayashi, H.; Ishii, M.; Sato, E.F.; Inoue, M.
Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone
Clin. Exp. Dermatol.
38
71-76
2013
Mus musculus (P21661)
brenda
Chen, Y.; Cao, W.; Zhou, S.; Shen, L.; Wen, J.
Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets
Exp. Biol. Med. (Maywood)
238
1259-1264
2013
Mus musculus
brenda
Tangprasittipap, A.; Chouwdee, S.; Phiwsaiya, K.; Laiphrom, S.; Senapin, S.; Flegel, T.W.; Sritunyalucksana, K.
Structure and expression of a shrimp prohormone convertase 2
Gen. Comp. Endocrinol.
178
185-193
2012
Penaeus monodon (I6M2I5)
brenda
Zhan, S.; Zhou, A.; Piper, C.; Yang, T.
Dynamic changes in proprotein convertase 2 activity in cortical neurons after ischemia/reperfusion and oxygen-glucose deprivation
Neural Regen. Res.
8
83-89
2013
Rattus norvegicus (P28841)
brenda
Nakamoto, K.; Aizawa, F.; Nishinaka, T.; Tokuyama, S.
Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus
Eur. J. Pharmacol.
762
459-463
2015
Mus musculus (P21661)
brenda
Tein, K.; Kasvandik, S.; Koks, S.; Vasar, E.; Terasmaa, A.
Prohormone convertase 2 activity is increased in the hippocampus of Wfs1 knockout mice
Front. Mol. Neurosci.
8
45
2015
Mus musculus (P21661)
brenda