Sequence of ERG9_YEAST
EC Number:2.5.1.21
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+
Other sequences found for EC No. 2.5.1.21
General information:
Sequence
0 MGKLLQLALH PVEMKAALKL KFCRTPLFSI YDQSTSPYLL HCFELLNLTS RSFAAVIREL
60 HPELRNCVTL FYLILRALDT IEDDMSIEHD LKIDLLRHFH EKLLLTKWSF DGNAPDVKDR
120 AVLTDFESIL IEFHKLKPEY QEVIKEITEK MGNGMADYIL DENYNLNGLQ TVHDYDVYCH
180 YVAGLVGDGL TRLIVIAKFA NESLYSNEQL YESMGLFLQK TNIIRDYNED LVDGRSFWPK
240 EIWSQYAPQL KDFMKPENEQ LGLDCINHLV LNALSHVIDV LTYLAGIHEQ STFQFCAIPQ
300 VMAIATLALV FNNREVLHGN VKIRKGTTCY LILKSRTLRG CVEIFDYYLR DIKSKLAVQD
360 PNFLKLNIQI SKIEQFMEEM YQDKLPPNVK PNETPIFLKV KERSRYDDEL VPTQQEEEYK
420 FNMVLSIILS VLLGFYYIYT LHRA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
414926
Fegueur M.,Richard L.,Charles A.D.,Karst F.
Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase.
Curr. Genet.
20
365-372
1991
414927
Jennings S.M.,Tsay Y.H.,Fisch T.M.,Robinson G.W.
Molecular cloning and characterization of the yeast gene for squalene synthetase.
Proc. Natl. Acad. Sci. U.S.A.
88
6038-6042
1991
414928
Johnston M.,Andrews S.,Brinkman R.,Cooper J.,Ding H.,Dover J.,Du Z.,Favello A.,Fulton L.,Gattung S.,Geisel C.,Kirsten J.,Kucaba T.,Hillier L.W.,Jier M.,Johnston L.,Langston Y.,Latreille P.,Louis E.J.,Macri C.,Mardis E.,Menezes S.,Mouser L.,Nhan M.,Rifkin L.,Riles L.,St Peter H.,Trevaskis E.,Vaughan K.,Vignati D.,Wilcox L.,Wohldman P.,Waterston R.,Wilson R.,Vaudin M.
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.
Science
265
2077-2082
1994
414929
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
414930
Zhang D.,Jennings S.M.,Robinson G.W.,Poulter C.D.
Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme.
Arch. Biochem. Biophys.
304
133-143
1993
414931
Li L.,Kaplan J.
Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.
J. Biol. Chem.
271
16927-16933
1996
414932
Grabowska D.,Karst F.,Szkopinska A.
Effect of squalene synthase gene disruption on synthesis of polyprenols in Saccharomyces cerevisiae.
FEBS Lett.
434
406-408
1998
414933
Kennedy M.A.,Barbuch R.,Bard M.
Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae.
Biochim. Biophys. Acta
1445
110-122
1999
414934
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
414935
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
414936
Jorda T.,Puig S.
Regulation of ergosterol biosynthesis in Saccharomyces cerevisiae.
Genes (Basel)
11
0-0
2020
