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Information on EC 2.5.1.21 - squalene synthase

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IUBMB Comments
This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP) . High concentrations of FPP inhibit the production of squalene but not of PSPP .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
farnesyltransferase, sqs, squalene synthetase, fdft1, farnesyl-diphosphate farnesyltransferase, ssase, sqase, squalene synthase 1, crsqs, lycopaoctaene synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+
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2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate
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; 1a
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presqualene diphosphate + NAD(P)H + H+ = squalene + diphosphate + NAD(P)+
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; 1b
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