Sequence of ACS_NEOBT
EC Number:4.2.3.42
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate
Other sequences found for EC No. 4.2.3.42
General information:
Sequence
0 MVPISTRSEV QDGLIAQARS LITRIVHNSD DVYGFGTLSC TVYDTAWVAL VTKHVNGIKH
60 WLFPESFHYI LASQCDDGTW CEDKTAQFDG VLNTIAGLLV LKRYRRDPLQ LKVDNRDLDS
120 RIKLATSALH SLLEEWDVST TNNVGFEIIV PTMLDLLVQE DPSLSFELKG REALTEIREA
180 KMNRFQPELL YQGKLMTLTH SLEALLGRID YDNVARYTVK GSMFASPSST AAYLMSASTW
240 DDEAETYLRY TITASTGKGS GGVPGVFPTT YFEYTWILST LFRAGFQSSE LDSPELTAMT
300 DTLLKAFKAF SGAIGLDSGI EPDVDDSAKI VTTLNMLGKP AHARYLCDNF EVETHFRVYP
360 RERDPSFSAN CNALAAFLHQ PDVEVYSSQI LKAASYLCER MWNADEKIDD KWNKSHLYSS
420 FLYTQVMTDL MAITEAGRLD GVFTRELLTR VCVTIFQSCL RAMLKQSHDG SWNQSLEETA
480 YAILHLTEAR RLCFFEQISE PLENSIYRGI TFLTTIDKPP MEYLWSDKVS YGSAYLAETY
540 VLAARRAAES TSVTNLVGSS IWKDNASTKM HKLVGLFHRT PLLKALPKWE LQASMIEASI
600 YQGLLQDARL EVLQRPKVDG GEYLSIIPFT WTSCSNSART NASASHLWEL MALSFFTYQV
660 DEFMEAVAGP AFKGRMTHLH AIIDEAVHCS QNRERTPGEC ENTNHVTSEL LQAVRFILDN
720 PTVRKASPYD RNTLLQELRI FLHAHVTQVE DNASFGRERL TGDKALTSYR SQLYRWVHTI
780 SSDHIAGPFC FYYATCLLGA TLTAHPPNDC FPKSSQKYLA AATCRHLSCM CRMYNDIGSW
840 NRDHREGNLN CLHFPEFSET TSDDAERKAS LLTLAQYERK QWCNALQQLE KEMVHGASEP
900 AAARLAKRRA CLIDMFCKVT DLYGQIYVLR DVSSVIKDVV RNGE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
261424
Oikawa H.,Toyomasu T.,Toshima H.,Ohashi S.,Kawaide H.,Kamiya Y.,Ohtsuka M.,Shinoda S.,Mitsuhashi W.,Sassa T.
Cloning and functional expression of cDNA encoding aphidicolan-16 beta-ol synthase: a key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin.
J. Am. Chem. Soc.
123
5154-5155
2001
261425
Toyomasu T.,Nakaminami K.,Toshima H.,Mie T.,Watanabe K.,Ito H.,Matsui H.,Mitsuhashi W.,Sassa T.,Oikawa H.
Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.
Biosci. Biotechnol. Biochem.
68
146-152
2004
261426
Fujii R.,Minami A.,Tsukagoshi T.,Sato N.,Sahara T.,Ohgiya S.,Gomi K.,Oikawa H.
Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha: heterologous expression of four biosynthetic genes in Aspergillus oryzae.
Biosci. Biotechnol. Biochem.
75
1813-1817
2011
