Sequence of PK3CB_HUMAN
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
General information:
Sequence
0 MCFSFIMPPA MADILDIWAV DSQIASDGSI PVDFLLPTGI YIQLEVPREA TISYIKQMLW
60 KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC DVRPFLPVLK LVTRSCDPGE
120 KLDSKIGVLI GKGLHEFDSL KDPEVNEFRR KMRKFSEEKI LSLVGLSWMD WLKQTYPPEH
180 EPSIPENLED KLYGGKLIVA VHFENCQDVF SFQVSPNMNP IKVNELAIQK RLTIHGKEDE
240 VSPYDYVLQV SGRVEYVFGD HPLIQFQYIR NCVMNRALPH FILVECCKIK KMYEQEMIAI
300 EAAINRNSSN LPLPLPPKKT RIISHVWENN NPFQIVLVKG NKLNTEETVK VHVRAGLFHG
360 TELLCKTIVS SEVSGKNDHI WNEPLEFDIN ICDLPRMARL CFAVYAVLDK VKTKKSTKTI
420 NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG QLRTGDIILH SWSSFPDELE EMLNPMGTVQ
480 TNPYTENATA LHVKFPENKK QPYYYPPFDK IIEKAAEIAS SDSANVSSRG GKKFLPVLKE
540 ILDRDPLSQL CENEMDLIWT LRQDCREIFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK
600 LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP FLDCALSRFL
660 LERALGNRRI GQFLFWHLRS EVHIPAVSVQ FGVILEAYCR GSVGHMKVLS KQVEALNKLK
720 TLNSLIKLNA VKLNRAKGKE AMHTCLKQSA YREALSDLQS PLNPCVILSE LYVEKCKYMD
780 SKMKPLWLVY NNKVFGEDSV GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG
840 CLATGDRSGL IEVVSTSETI ADIQLNSSNV AAAAAFNKDA LLNWLKEYNS GDDLDRAIEE
900 FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG IKRERVPFIL
960 TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF ITLFALMLTA GLPELTSVKD
1020 IQYLKDSLAL GKSEEEALKQ FKQKFDEALR ESWTTKVNWM AHTVRKDYRS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205797
Hu P.,Mondino A.,Skolnik E.Y.,Schlessinger J.
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
Mol. Cell. Biol.
13
7677-7688
1993
205798
Kossila M.,Sinkovic M.,Karkkainen P.,Laukkanen M.O.,Miettinen R.,Rissanen J.,Kekalainen P.,Kuusisto J.,Yla-Herttuala S.,Laakso M.
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
Diabetes
49
1740-1743
2000
205800
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
205801
Czupalla C.,Culo M.,Muller E.C.,Brock C.,Reusch H.P.,Spicher K.,Krause E.,Nurnberg B.
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
J. Biol. Chem.
278
11536-11545
2003
205802
Meier T.I.,Cook J.A.,Thomas J.E.,Radding J.A.,Horn C.,Lingaraj T.,Smith M.C.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.
Protein Expr. Purif.
35
218-224
2004
205803
Jia S.,Liu Z.,Zhang S.,Liu P.,Zhang L.,Lee S.H.,Zhang J.,Signoretti S.,Loda M.,Roberts T.M.,Zhao J.J.
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.
Nature
454
776-779
2008
205804
Wee S.,Wiederschain D.,Maira S.-M.,Loo A.,Miller C.,deBeaumont R.,Stegmeier F.,Yao Y.-M.,Lengauer C.
PTEN-deficient cancers depend on PIK3CB.
Proc. Natl. Acad. Sci. U.S.A.
105
13057-13062
2008
205805
Rabinovsky R.,Pochanard P.,McNear C.,Brachmann S.M.,Duke-Cohan J.S.,Garraway L.A.,Sellers W.R.
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Mol. Cell. Biol.
29
5377-5388
2009
205806
Dbouk H.A.,Pang H.,Fiser A.,Backer J.M.
A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.
Proc. Natl. Acad. Sci. U.S.A.
107
19897-19902
2010
205807
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
205808
Kumar A.,Redondo-Munoz J.,Perez-Garcia V.,Cortes I.,Chagoyen M.,Carrera A.C.
Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival.
Mol. Cell. Biol.
31
2122-2133
2011
205809
Dbouk H.A.,Backer J.M.
A beta version of life: p110beta takes center stage.
Oncotarget
1
729-733
2010
205810
Gratacap M.-P.,Guillermet-Guibert J.,Martin V.,Chicanne G.,Tronchere H.,Gaits-Iacovoni F.,Payrastre B.
Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions.
Adv. Enzyme Regul.
51
106-116
2011
