Sequence of PK3CA_MOUSE
EC Number:2.7.1.153
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Other sequences found for EC No. 2.7.1.153
General information:
Sequence
0 MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLVTIKHELF REARKYPLHQ
60 LLQDETSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK VIEPVGNREE KILNREIGFV
120 IGMPVCEFDM VKDPEVQDFR RNILNVCKEA VDLRDLNSPH SRAMYVYPPN VESSPELPKH
180 IYNKLDKGQI IVVIWVIVSP NNDKQKYTLK INHDCVPEQV IAEAIRKKTR SMLLSSEQLK
240 LCVLEYQGKY ILKVCGCDEY FLEKYPLSQY KYIRSCIMLG RMPNLMLMAK ESLYSQLPID
300 SFTMPSYSRR ISTATPYMNG ETSTKSLWVI NSALRIKILC ATYVNVNIRD IDKIYVRTGI
360 YHGGEPLCDN VNTQRVPCSN PRWNEWLNYD IYIPDLPRAA RLCLSICSVK GRKGAKEEHC
420 PLAWGNINLF DYTDTLVSGK MALNLWPVPH GLEDLLNPIG VTGSNPNKET PCLELEFDWF
480 SSVVKFPDMS VIEEHANWSV SREAGFSYSH TGLSNRLARD NELRENDKEQ LRALCTRDPL
540 SEITEQEKDF LWSHRHYCVT IPEILPKLLL SVKWNSRDEV AQMYCLVKDW PPIKPEQAME
600 LLDCNYPDPM VRSFAVRCLE KYLTDDKLSQ YLIQLVQVLK YEQYLDNLLV RFLLKKALTN
660 QRIGHFFFWH LKSEMHNKTV SQRFGLLLES YCRACGMYLK HLNRQVEAME KLINLTDILK
720 QEKKDETQKV QMKFLVEQMR QPDFMDALQG FLSPLNPAHQ LGNLRLEECR IMSSAKRPLW
780 LNWENPDIMS ELLFQNNEII FKNGDDLRQD MLTLQIIRIM ENIWQNQGLD LRMLPYGCLS
840 IGDCVGLIEV VRNSHTIMQI QCKGGLKGAL QFNSHTLHQW LKDKNKGEIY DAAIDLFTRS
900 CAGYCVATFI LGIGDRHNSN IMVKDDGQLF HIDFGHFLDH KKKKFGYKRE RVPFVLTQDF
960 LIVISKGAQE YTKTREFERF QEMCYKAYLA IRQHANLFIN LFSMMLGSGM PELQSFDDIA
1020 YIRKTLALDK TEQEALEYFT KQMNDAHHGG WTTKMDWIFH TIKQHALN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
205783
Klippel A.,Escobedo J.A.,Hirano M.,Williams L.T.
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.
Mol. Cell. Biol.
14
2675-2685
1994
205785
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
205786
Drakas R.,Tu X.,Baserga R.
Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase.
Proc. Natl. Acad. Sci. U.S.A.
101
9272-9276
2004
205787
Knight Z.A.,Gonzalez B.,Feldman M.E.,Zunder E.R.,Goldenberg D.D.,Williams O.,Loewith R.,Stokoe D.,Balla A.,Toth B.,Balla T.,Weiss W.A.,Williams R.L.,Shokat K.M.
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell
125
733-747
2006
205788
Foukas L.C.,Claret M.,Pearce W.,Okkenhaug K.,Meek S.,Peskett E.,Sancho S.,Smith A.J.H.,Withers D.J.,Vanhaesebroeck B.
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.
Nature
441
366-370
2006
205789
Zhao J.J.,Cheng H.,Jia S.,Wang L.,Gjoerup O.V.,Mikami A.,Roberts T.M.
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.
Proc. Natl. Acad. Sci. U.S.A.
103
16296-16300
2006
205790
Gupta S.,Ramjaun A.R.,Haiko P.,Wang Y.,Warne P.H.,Nicke B.,Nye E.,Stamp G.,Alitalo K.,Downward J.
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Cell
129
957-968
2007
205791
Graupera M.,Guillermet-Guibert J.,Foukas L.C.,Phng L.-K.,Cain R.J.,Salpekar A.,Pearce W.,Meek S.,Millan J.,Cutillas P.R.,Smith A.J.H.,Ridley A.J.,Ruhrberg C.,Gerhardt H.,Vanhaesebroeck B.
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
Nature
453
662-666
2008
205792
Tamura N.,Hazeki K.,Okazaki N.,Kametani Y.,Murakami H.,Takaba Y.,Ishikawa Y.,Nigorikawa K.,Hazeki O.
Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages.
Biochem. J.
423
99-108
2009
205793
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
205794
Bekhite M.M.,Finkensieper A.,Binas S.,Mueller J.,Wetzker R.,Figulla H.-R.,Sauer H.,Wartenberg M.
VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.
J. Cell Sci.
124
1819-1830
2011
