Sequence of AMS1_ARTAN

amorpha-4,11-diene synthase

Q9AR04

546

63933

131243

Mercke P.E.,Bengtsson M.,Bouwmeester H.J.,Posthumus M.A.,Brodelius P.E.

Molecular cloning, expression, and characterization of a amorpha-4,11-diene synthase from, a key enzyme of artemisinin biosynthesis of Artemisia annua L.

Arch. Biochem. Biophys.

381

173-180

2000

131245

Chang Y.-J.,Song S.-H.,Park S.-H.,Kim S.-U.

Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis.

Arch. Biochem. Biophys.

383

178-184

2000

131246

Wallaart T.E.,Bouwmeester H.J.,Hille J.,Poppinga L.,Maijers N.C.A.

Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin.

Planta

212

460-465

2001

131249

Alam P.,Kiran U.,Ahmad M.M.,Kamaluddin X.,Khan M.A.,Jhanwar S.,Abdin M.Z.

Isolation, characterization and structural studies of amorpha-4,11-diene synthase (ADS(3963)) from Artemisia annua L.

Bioinformation

4

421-429

2010

131254

Muangphrom P.,Seki H.,Suzuki M.,Komori A.,Nishiwaki M.,Mikawa R.,Fukushima E.O.,Muranaka T.

Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing Artemisia species: The discovery of novel koidzumiol and (+)-alpha-bisabolol synthases.

Plant Cell Physiol.

57

1678-1688

2016

131255

Shen Q.,Zhang L.,Liao Z.,Wang S.,Yan T.,Shi P.,Liu M.,Fu X.,Pan Q.,Wang Y.,Lv Z.,Lu X.,Zhang F.,Jiang W.,Ma Y.,Chen M.,Hao X.,Li L.,Tang Y.,Lv G.,Zhou Y.,Sun X.,Brodelius P.E.,Rose J.K.C.,Tang K.

The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis.

Mol. Plant

11

776-788

2018

131257

Bouwmeester H.J.,Wallaart T.E.,Janssen M.H.,van Loo B.,Jansen B.J.,Posthumus M.A.,Schmidt C.O.,De Kraker J.W.,Koenig W.A.,Franssen M.C.

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis.

Phytochemistry

52

843-854

1999

131258

Ro D.-K.,Paradise E.M.,Ouellet M.,Fisher K.J.,Newman K.L.,Ndungu J.M.,Ho K.A.,Eachus R.A.,Ham T.S.,Kirby J.,Chang M.C.Y.,Withers S.T.,Shiba Y.,Sarpong R.,Keasling J.D.

Production of the antimalarial drug precursor artemisinic acid in engineered yeast.

Nature

440

940-943

2006

131259

Olsson M.E.,Olofsson L.M.,Lindahl A.-L.,Lundgren A.,Brodelius M.,Brodelius P.E.

Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.

Phytochemistry

70

1123-1128

2009

131261

Olofsson L.,Lundgren A.,Brodelius P.E.

Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L.

Plant Sci.

183

9-13

2012

131262

Westfall P.J.,Pitera D.J.,Lenihan J.R.,Eng D.,Woolard F.X.,Regentin R.,Horning T.,Tsuruta H.,Melis D.J.,Owens A.,Fickes S.,Diola D.,Benjamin K.R.,Keasling J.D.,Leavell M.D.,McPhee D.J.,Renninger N.S.,Newman J.D.,Paddon C.J.

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.

Proc. Natl. Acad. Sci. U.S.A.

109

0-0

2012

131263

Paddon C.J.,Westfall P.J.,Pitera D.J.,Benjamin K.,Fisher K.,McPhee D.,Leavell M.D.,Tai A.,Main A.,Eng D.,Polichuk D.R.,Teoh K.H.,Reed D.W.,Treynor T.,Lenihan J.,Fleck M.,Bajad S.,Dang G.,Diola D.,Dorin G.,Ellens K.W.,Fickes S.,Galazzo J.,Gaucher S.P.,Geistlinger T.,Henry R.,Hepp M.,Horning T.,Iqbal T.,Jiang H.,Kizer L.,Lieu B.,Melis D.,Moss N.,Regentin R.,Secrest S.,Tsuruta H.,Vazquez R.,Westblade L.F.,Xu L.,Yu M.,Zhang Y.,Zhao L.,Lievense J.,Covello P.S.,Keasling J.D.,Reiling K.K.,Renninger N.S.,Newman J.D.

High-level semi-synthetic production of the potent antimalarial artemisinin.

Nature

496

528-532

2013

131264

Tu Y.

Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).

Angew. Chem. Int. Ed.

55

10210-10226

2016

131265

Judd R.,Bagley M.C.,Li M.,Zhu Y.,Lei C.,Yuzuak S.,Ekeloef M.,Pu G.,Zhao X.,Muddiman D.C.,Xie D.-Y.

Artemisinin biosynthesis in non-glandular trichome cells of Artemisia annua.

Mol. Plant

12

704-714

2019

131266

Liu Y.,Jing S.-X.,Luo S.-H.,Li S.-H.

Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis.

Nat. Prod. Rep.

36

626-665

2019

131267

Uzun T.,Toptas O.

Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?

Chin. Med. J.

15

54-54

2020

131268

Cheong D.H.J.,Tan D.W.S.,Wong F.W.S.,Tran T.

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases.

Pharmacol. Res.

158

104901-104901

2020