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Information on EC 4.2.3.24 - amorpha-4,11-diene synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.24 amorpha-4,11-diene synthase
IUBMB Comments
Requires Mg2+ and Mn2+ for activity. This is a key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin . Catalyses the formation of both olefinic [e.g. amorpha-4,11-diene, amorpha-4,7(11)-diene, gamma-humulene and beta-sesquiphellandrene] and oxygenated (e.g. amorpha-4-en-7-ol) sesquiterpenes, with amorpha-4,11-diene being the major product. When geranyl diphosphate is used as a substrate, no monoterpenes are produced .
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Word Map
The expected taxonomic range for this enzyme is: Artemisia annua
Synonyms
ADS, ADS1, ADS3963, amorpha-4,11-diene synthase, amorphadiene synthase, AMS, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = amorpha-4,11-diene + diphosphate
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