Sequence of GRAA_HUMAN
EC Number:3.4.21.78
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates
Other sequences found for EC No. 3.4.21.78
General information:
Sequence
0 MRNSYRFLAS SLSVVVSLLL IPEDVCEKII GGNEVTPHSR PYMVLLSLDR KTICAGALIA
60 KDWVLTAAHC NLNKRSQVIL GAHSITREEP TKQIMLVKKE FPYPCYDPAT REGDLKLLQL
120 MEKAKINKYV TILHLPKKGD DVKPGTMCQV AGWGRTHNSA SWSDTLREVN ITIIDRKVCN
180 DRNHYNFNPV IGMNMVCAGS LRGGRDSCNG DSGSPLLCEG VFRGVTSFGL ENKCGDPRGP
240 GVYILLSKKH LNWIIMTIKG AV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1193863
Gershenfeld H.K.,Hershberger R.J.,Shows T.B.,Weissman I.L.
Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.
Proc. Natl. Acad. Sci. U.S.A.
85
1184-1188
1988
1193865
Schmutz J.,Martin J.,Terry A.,Couronne O.,Grimwood J.,Lowry S.,Gordon L.A.,Scott D.,Xie G.,Huang W.,Hellsten U.,Tran-Gyamfi M.,She X.,Prabhakar S.,Aerts A.,Altherr M.,Bajorek E.,Black S.,Branscomb E.,Caoile C.,Challacombe J.F.,Chan Y.M.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Lopez F.,Lou Y.,Martinez D.,Medina C.,Morgan J.,Nandkeshwar R.,Noonan J.P.,Pitluck S.,Pollard M.,Predki P.,Priest J.,Ramirez L.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wheeler J.,Wu K.,Yang J.,Dickson M.,Cheng J.-F.,Eichler E.E.,Olsen A.,Pennacchio L.A.,Rokhsar D.S.,Richardson P.,Lucas S.M.,Myers R.M.,Rubin E.M.
The DNA sequence and comparative analysis of human chromosome 5.
Nature
431
268-274
2004
1193866
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1193867
Ruike Y.,Katsuma S.,Hirasawa A.,Tsujimoto G.
Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A.
J. Hum. Genet.
52
172-178
2007
1193869
Poe M.,Bennett C.D.,Biddison W.E.,Blake J.T.,Norton G.P.,Rodkey J.A.,Sigal N.H.,Turner R.V.,Wu J.K.,Zweerink H.J.
Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.
J. Biol. Chem.
263
13215-13222
1988
1193870
Hameed A.,Lowrey D.M.,Lichtenheld M.,Podack E.R.
Characterization of three serine esterases isolated from human IL-2 activated killer cells.
J. Immunol.
141
3142-3147
1988
1193871
Kraehenbuhl O.,Rey C.,Jenne D.E.,Lanzavecchia A.,Groscurth P.,Carrel S.,Tschopp J.
Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.
J. Immunol.
141
3471-3477
1988
1193872
Beresford P.J.,Zhang D.,Oh D.Y.,Fan Z.,Greer E.L.,Russo M.L.,Jaju M.,Lieberman J.
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.
J. Biol. Chem.
276
43285-43293
2001
1193873
Fan Z.,Beresford P.J.,Oh D.Y.,Zhang D.,Lieberman J.
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.
Cell
112
659-672
2003
1193874
Fan Z.,Beresford P.J.,Zhang D.,Xu Z.,Novina C.D.,Yoshida A.,Pommier Y.,Lieberman J.
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.
Nat. Immunol.
4
145-153
2003
1193875
Chowdhury D.,Beresford P.J.,Zhu P.,Zhang D.,Sung J.S.,Demple B.,Perrino F.W.,Lieberman J.
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.
Mol. Cell
23
133-142
2006
1193876
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
1193877
Thiery J.,Keefe D.,Saffarian S.,Martinvalet D.,Walch M.,Boucrot E.,Kirchhausen T.,Lieberman J.
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.
Blood
115
1582-1593
2010
1193878
Zhou Z.,He H.,Wang K.,Shi X.,Wang Y.,Su Y.,Wang Y.,Li D.,Liu W.,Zhang Y.,Shen L.,Han W.,Shen L.,Ding J.,Shao F.
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
Science
368
0-0
2020
1193879
Murphy M.E.P.,Moult J.,Bleackley R.C.,Gershenfeld H.,Weissman I.L.,James M.N.G.
Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes.
Proteins
4
190-204
1988
1193880
Bell J.K.,Goetz D.H.,Mahrus S.,Harris J.L.,Fletterick R.J.,Craik C.S.
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Nat. Struct. Biol.
10
527-534
2003
1193881
Hink-Schauer C.,Estebanez-Perpina E.,Kurschus F.C.,Bode W.,Jenne D.E.
Crystal structure of the apoptosis-inducing human granzyme A dimer.
Nat. Struct. Biol.
10
535-540
2003
