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Information on EC 3.4.21.78 - Granzyme A

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.78 Granzyme A
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Word Map
  • 3.4.21.78
  • thrombospondin-1
  • angiogenesis
  • perforin
  • angiogenic
  • granule
  • killer
  • antiangiogenic
  • cytolytic
  • t-cells
  • metastasis
  • matricellular
  • microvessels
  • collagen
  • integrins
  • microvascular
  • lytic
  • exocytosis
  • tgf-beta1
  • neovascularization
  • integrin-associated
  • granulysin
  • ifn-gamma
  • angiostatic
  • granule-associated
  • metronomic
  • clpap
  • tregs
  • endostatin
  • factor-beta
  • proangiogenic
  • lymphocyte-mediated
  • vegf-a
  • angiogenesis-related
  • medicine
  • ctl-mediated
  • alphavbeta3
  • corneal
  • caspase-independent
  • lymphokine-activated
  • properdin
The enzyme appears in viruses and cellular organisms
Synonyms
tsp-1, h factor, gzm a, gzma/k, ctla3, ctl tryptase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates
show the reaction diagram
including fibronectin, type IV collagen and nucleolin. Preferential cleavage:-Arg-+-,-Lys-+- >>-Phe-+- in small molecule substrates, he term-+- depicts the point of cleavage
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