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Information on EC 3.4.21.78 - granzyme A

for references in articles please use BRENDA:EC3.4.21.78

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IUBMB Comments

From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe-

The enzyme appears in viruses and cellular organisms

Synonyms
tsp-1, granzyme a, h factor, gzm a, gzma/k, ctla3, ctl tryptase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates
show the reaction diagram
including fibronectin, type IV collagen and nucleolin. Preferential cleavage:-Arg-+-,-Lys-+- >>-Phe-+- in small molecule substrates, he term-+- depicts the point of cleavage
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