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Information on EC 3.4.21.78 - Granzyme A

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.78 Granzyme A
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
Autocrine thymic lymphoma granzyme-like serine protease, CTL tryptase, CTLA3, Cytotoxic T lymphocyte serine protease, GrA, Gzm A, Gzma, GzmA/K, H factor, Hanukkah factor, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-/-, -Lys-/- >> -Phe-/- in small molecule substrates
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including fibronectin, type IV collagen and nucleolin. Preferential cleavage:-Arg-+-,-Lys-+- >>-Phe-+- in small molecule substrates, he term-+- depicts the point of cleavage
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