Sequence of TPH1_RAT
EC Number:1.14.16.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Other sequences found for EC No. 1.14.16.4
General information:
Sequence
0 MIEDNKENKD HSSERGRVTL IFSLKNEVGG LIKALKIFQE NHVNLLHIES RKSKRRNSEF
60 EIFVDCDINR EQLNDIFPLL KSHTTVLSVD SPDQLPEKED VMETVPWFPK KISDLDFCAN
120 RVLLYGSELD ADHPGFKDNV YRRRRKYFAE LAMNYKHGDP IPKIEFTEEE IKTWGTIFRE
180 LNKLYPTHAC REYLRNLPLL SKYCGYREDN VPQLEDVSNF LKERTGFSIR PVAGYLSPRD
240 FLSGLAFRVF HCTQYVRHSS DPLYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA
300 SEETVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LRHALSGHAK VKPFDPKVAC
360 KQECLITSFQ DVYFVSESFE DAKEKMREFA KTVKRPFGVK YNPYTQSIQV LRDSKSITSA
420 MNELRHDLDV VNDALARVSR WPSV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
110710
Darmon M.C.,Guibert B.,Leviel V.,Ehret M.,Maitre M.,Mallet J.
Sequence of two mRNAs encoding active rat tryptophan hydroxylase.
J. Neurochem.
51
312-316
1988
110711
Kim K.S.,Wessel T.C.,Stone D.M.,Carver C.H.,Joh T.H.,Park D.H.
Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons.
Brain Res. Mol. Brain Res.
9
277-283
1991
110712
Darmon M.C.,Grima B.,Cash C.D.,Maitre M.,Mallet J.
Isolation of a rat pineal gland cDNA clone homologous to tyrosine and phenylalanine hydroxylases.
FEBS Lett.
206
43-46
1986
110713
Iida Y.,Sawabe K.,Kojima M.,Oguro K.,Nakanishi N.,Hasegawa H.
Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.
Eur. J. Biochem.
269
4780-4788
2002
