Sequence of TDH_PYRHO
EC Number:1.1.1.103
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
L-threonine 3-dehydrogenase
O58389
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
348
37786
Reaction
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
Other sequences found for EC No. 1.1.1.103
General information:
Sequence
0 MSEKMVAIMK TKPGYGAELV EVDVPKPGPG EVLIKVLATS ICGTDLHIYE WNEWAQSRIK
60 PPQIMGHEVA GEVVEIGPGV EGIEVGDYVS VETHIVCGKC YACRRGQYHV CQNTKIFGVD
120 TDGVFAEYAV VPAQNIWKNP KSIPPEYATL QEPLGNAVDT VLAGPISGKS VLITGAGPLG
180 LLGIAVAKAS GAYPVIVSEP SDFRRELAKK VGADYVINPF EEDVVKEVMD ITDGNGVDVF
240 LEFSGAPKAL EQGLQAVTPA GRVSLLGLYP GKVTIDFNNL IIFKALTIYG ITGRHLWETW
300 YTVSRLLQSG KLNLDPIITH KYKGFDKYEE AFELMRAGKT GKVVFMLK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
107699
Kawarabayasi Y.,Sawada M.,Horikawa H.,Haikawa Y.,Hino Y.,Yamamoto S.,Sekine M.,Baba S.,Kosugi H.,Hosoyama A.,Nagai Y.,Sakai M.,Ogura K.,Otsuka R.,Nakazawa H.,Takamiya M.,Ohfuku Y.,Funahashi T.,Tanaka T.,Kudoh Y.,Yamazaki J.,Kushida N.,Oguchi A.,Aoki K.,Yoshizawa T.,Nakamura Y.,Robb F.T.,Horikoshi K.,Masuchi Y.,Shizuya H.,Kikuchi H.
Complete sequence and gene organization of the genome of a hyper-thermophilic archaebacterium, Pyrococcus horikoshii OT3.
DNA Res.
5
55-76
1998
107700
Shimizu Y.,Sakuraba H.,Kawakami R.,Goda S.,Kawarabayasi Y.,Ohshima T.
L-Threonine dehydrogenase from the hyperthermophilic archaeon Pyrococcus horikoshii OT3: gene cloning and enzymatic characterization.
Extremophiles
9
317-324
2005
107701
Higashi N.,Fukada H.,Ishikawa K.
Kinetic study of thermostable L-threonine dehydrogenase from an archaeon Pyrococcus horikoshii.
J. Biosci. Bioeng.
99
175-180
2005
107702
Higashi N.,Tanimoto K.,Nishioka M.,Ishikawa K.,Taya M.
Investigating a catalytic mechanism of hyperthermophilic L-threonine dehydrogenase from Pyrococcus horikoshii.
J. Biochem.
144
77-85
2008
107704
Ishikawa K.,Higashi N.,Nakamura T.,Matsuura T.,Nakagawa A.
The first crystal structure of L-threonine dehydrogenase.
J. Mol. Biol.
366
857-867
2007
