Sequence of AMPL_YEAST
EC Number:3.4.11.22
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Other sequences found for EC No. 3.4.11.22
General information:
Sequence
0 MEEQREILEQ LKKTLQMLTV EPSKNNQIAN EEKEKKENEN SWCILEHNYE DIAQEFIDFI
60 YKNPTTYHVV SFFAELLDKH NFKYLSEKSN WQDSIGEDGG KFYTIRNGTN LSAFILGKNW
120 RAEKGVGVIG SHVDALTVKL KPVSFKDTAE GYGRIAVAPY GGTLNELWLD RDLGIGGRLL
180 YKKKGTNEIK SALVDSTPLP VCRIPSLAPH FGKPAEGPFD KEDQTIPVIG FPTPDEEGNE
240 PPTDDEKKSP LFGKHCIHLL RYVAKLAGVE VSELIQMDLD LFDVQKGTIG GIGKHFLFAP
300 RLDDRLCSFA AMIALICYAK DVNTEESDLF STVTLYDNEE IGSLTRQGAK GGLLESVVER
360 SSSAFTKKPV DLHTVWANSI ILSADVNHLY NPNFPEVYLK NHFPVPNVGI TLSLDPNGHM
420 ATDVVGTALV EELARRNGDK VQYFQIKNNS RSGGTIGPSL ASQTGARTID LGIAQLSMHS
480 IRAATGSKDV GLGVKFFNGF FKHWRSVYDE FGEL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1156181
Cueva R.,Garcia-Alvarez N.,Suarez-Rendueles P.
Yeast vacuolar aminopeptidase yscI. Isolation and regulation of the APE1 (LAP4) structural gene.
FEBS Lett.
259
125-129
1989
1156182
Chang Y.-H.,Smith J.A.
Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.
J. Biol. Chem.
264
6979-6983
1989
1156183
Cheret G.,Pallier C.,Valens M.,Daignan-Fornier B.,Fukuhara H.,Bolotin-Fukuhara M.,Sor F.
The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast.
Yeast
9
1259-1265
1993
1156184
Dujon B.,Alexandraki D.,Andre B.,Ansorge W.,Baladron V.,Ballesta J.P.G.,Banrevi A.,Bolle P.-A.,Bolotin-Fukuhara M.,Bossier P.,Bou G.,Boyer J.,Buitrago M.J.,Cheret G.,Colleaux L.,Daignan-Fornier B.,del Rey F.,Dion C.,Domdey H.,Duesterhoeft A.,Duesterhus S.,Entian K.-D.,Erfle H.,Esteban P.F.,Feldmann H.,Fernandes L.,Fobo G.M.,Fritz C.,Fukuhara H.,Gabel C.,Gaillon L.,Garcia-Cantalejo J.M.,Garcia-Ramirez J.J.,Gent M.E.,Ghazvini M.,Goffeau A.,Gonzalez A.,Grothues D.,Guerreiro P.,Hegemann J.H.,Hewitt N.,Hilger F.,Hollenberg C.P.,Horaitis O.,Indge K.J.,Jacquier A.,James C.M.,Jauniaux J.-C.,Jimenez A.,Keuchel H.,Kirchrath L.,Kleine K.,Koetter P.,Legrain P.,Liebl S.,Louis E.J.,Maia e Silva A.,Marck C.,Monnier A.-L.,Moestl D.,Mueller S.,Obermaier B.,Oliver S.G.,Pallier C.,Pascolo S.,Pfeiffer F.,Philippsen P.,Planta R.J.,Pohl F.M.,Pohl T.M.,Poehlmann R.,Portetelle D.,Purnelle B.,Puzos V.,Ramezani Rad M.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Richard G.-F.,Rieger M.,Rodrigues-Pousada C.,Rose M.,Rupp T.,Santos M.A.,Schwager C.,Sensen C.,Skala J.,Soares H.,Sor F.,Stegemann J.,Tettelin H.,Thierry A.,Tzermia M.,Urrestarazu L.A.,van Dyck L.,van Vliet-Reedijk J.C.,Valens M.,Vandenbol M.,Vilela C.,Vissers S.,von Wettstein D.,Voss H.,Wiemann S.,Xu G.,Zimmermann J.,Haasemann M.,Becker I.,Mewes H.-W.
Complete DNA sequence of yeast chromosome XI.
Nature
369
371-378
1994
1156185
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
1156187
Matile P.,Wiemken A.,Guyer W.
A lysosomal aminopeptidase isozyme in differentiating yeast cells and protoplasts.
Planta
96
43-53
1971
1156188
Metz G.,Roehm K.H.
Yeast aminopeptidase I. Chemical composition and catalytic properties.
Biochim. Biophys. Acta
429
933-949
1976
1156189
Frey J.,Roehm K.H.
Subcellular localization and levels of aminopeptidases and dipeptidase in Saccharomyces cerevisiae.
Biochim. Biophys. Acta
527
31-41
1978
1156190
Trumbly R.J.,Bradley G.
Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae.
J. Bacteriol.
156
36-48
1983
1156191
Roehm K.H.
Chloride as allosteric effector of yeast aminopeptidase I.
Arch. Biochem. Biophys.
239
216-225
1985
1156193
Achstetter T.,Wolf D.H.
Proteinases, proteolysis and biological control in the yeast Saccharomyces cerevisiae.
Yeast
1
139-157
1985
1156194
Klionsky D.J.,Cueva R.,Yaver D.S.
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.
J. Cell Biol.
119
287-299
1992
1156195
Segui-Real B.,Martinez M.,Sandoval I.V.
Yeast aminopeptidase I is post-translationally sorted from the cytosol to the vacuole by a mechanism mediated by its bipartite N-terminal extension.
EMBO J.
14
5476-5484
1995
1156196
Oda M.N.,Scott S.V.,Hefner-Gravink A.,Caffarelli A.D.,Klionsky D.J.
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
J. Cell Biol.
132
999-1010
1996
1156197
Scott S.V.,Hefner-Gravink A.,Morano K.A.,Noda T.,Ohsumi Y.,Klionsky D.J.
Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.
Proc. Natl. Acad. Sci. U.S.A.
93
12304-12308
1996
1156198
Kim J.,Scott S.V.,Oda M.N.,Klionsky D.J.
Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway.
J. Cell Biol.
137
609-618
1997
1156199
Scott S.V.,Baba M.,Ohsumi Y.,Klionsky D.J.
Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism.
J. Cell Biol.
138
37-44
1997
1156200
Baba M.,Osumi M.,Scott S.V.,Klionsky D.J.,Ohsumi Y.
Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome.
J. Cell Biol.
139
1687-1695
1997
1156201
Andrei-Selmer C.,Knuppel A.,Satyanarayana C.,Heese C.,Schu P.V.
A new class of mutants deficient in dodecamerization of aminopeptidase 1 and vacuolar transport.
J. Biol. Chem.
276
11606-11614
2001
1156202
Leber R.,Silles E.,Sandoval I.V.,Mazon M.J.
Yol082p, a novel CVT protein involved in the selective targeting of aminopeptidase I to the yeast vacuole.
J. Biol. Chem.
276
29210-29217
2001
1156203
Scott S.V.,Guan J.,Hutchins M.U.,Kim J.,Klionsky D.J.
Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway.
Mol. Cell
7
1131-1141
2001
1156204
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
1156205
Shintani T.,Klionsky D.J.
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway.
J. Biol. Chem.
279
29889-29894
2004
1156206
Adachi W.,Suzuki N.N.,Fujioka Y.,Suzuki K.,Ohsumi Y.,Inagaki F.
Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
Acta Crystallogr. F
63
200-203
2007
1156208
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
1156209
Morales Quinones M.,Winston J.T.,Stromhaug P.E.
Propeptide of aminopeptidase 1 protein mediates aggregation and vesicle formation in cytoplasm-to-vacuole targeting pathway.
J. Biol. Chem.
287
10121-10133
2012
