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Information on EC 3.4.11.22 - aminopeptidase I
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3.4.11.22 aminopeptidase ISpecify your search results
Word Map
- 3.4.11.22
- spondylitis
-
ankylosing
-
trim
- aminopeptidases
-
histocompatibility
- vacuole
-
hla-b27
- autoimmune
- psoriasis
-
eraps
-
cargo
-
cytoplasm-to-vacuole
-
peptidome
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macroautophagy
- spondyloarthritis
- allotypes
- oxytocinase
- bestatin
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double-membrane
- maltase
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exopeptidase
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immunopeptidome
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tnfaip3
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as-associated
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antigen-processing
-
birdshot
- medicine
-
traf3ip2
-
autoinflammatory
- analysis
- nutrition
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Synonyms
erap1, aminopeptidase i, endoplasmic reticulum aminopeptidase 1, leucine-aminopeptidase, eraap, endoplasmic reticulum aminopeptidase, a-lap, arts-1, aminopeptidase 1, lapase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Actinase AS
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alpha-Aminoacyl-peptide hydrolase
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Aminooligopeptidase
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Aminopeptidase
aminopeptidase I
Aminopeptidase III
Aminopeptidase yscI
Aminopeptidase yscII
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Aminopeptidase yscXVI
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Aminopolypeptidase
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Amylorhizin aminopeptidase
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Amylorizin
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API
endoplasmic reticulum aminopeptidase 1
ERAAP
ERAP1
L-aminopeptidase
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LAP
LAP II
LAP4
LAPIV
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Leu.AP
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Leucin aminopeptidase V
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leucine aminopeptidase
leucine aminopeptidase II
Leucine aminopeptidase IV
Leucineaminopeptidase I
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Metallo aminopeptidase
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Polypeptidase
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vacuolar aminopeptidase I
Yeast aminopeptidase I
additional information
Aminopeptidase
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Aminopeptidase III
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Aminopeptidase yscI
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API
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Leucine aminopeptidase IV
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Yeast aminopeptidase I
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additional information
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the enzyme belongs to the M1 peptidase family
additional information
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the enzyme belongs to the peptidase family M42
additional information
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the enzyme belongs to the peptidase family M1
additional information
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the enzyme belongs to the peptidase family M18
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
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Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
active site structure, reaction mechanism
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Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
catalysis depends on a catalytic metal, a carboxylate and a protonated imidazole group, whereas substrate binding requires one phenol and one carboxylate group
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Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
cobalt-dependent exopeptidase
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Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Gly-Gly bond is preferably hydrolyzed
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Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
Gly-Gly bond is preferably hydrolyzed
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Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates
cobalt-dependent exopeptidase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY
9031-94-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-(2-[(4-methylbenzene-1-sulfonyl)amino]ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2-[(leucylamino)methyl]piperidine-1-carboxylate + H2O
N-[2-(6-hydroxy-1,3-dioxo-6,6a-dihydro-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-4-methylbenzene-1-sulfonamide + hexahydroimidazo[1,5-a]pyridin-3(2H)-one + 2-amino-4-methylpentanoic acid
two-photon fluorescent probe SNCL, can be applied for monitoring of the activity in living cells and tissues
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?
Ala-beta-naphthylamide + H2O
Ala + beta-naphthylamine
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?
Asp 2-naphthylamide + H2O
Asp + 2-naphthylamine
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very slight activity
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?
AYWANATRSGA + H2O
L-Ala + YWANATRSGA
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high activity compared to other peptide substrates
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?
azocasein + H2O
protein fragments of azocasein of MW 71 kDa, 83 kDa, and 22 kDa
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?
EFAPGNYPAD + H2O
L-Glu + FAPGNYPAD
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low activity compared to other peptide substrates
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?
EFAPGNYPAK + H2O
L-Glu + FAPGNYPAK
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low activity compared to other peptide substrates
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?
EFAPGNYPAL + H2O
L-Glu + FAPGNYPAL
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high activity compared to other peptide substrates
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?
HSDAVFTDNYTRLRKQMAVKKYLNSILN + H2O
His + SDAVFTDNYTRLRKQM + AVKKYLN + SILN
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protein VIP
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?
L-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
L-Ala-Ala-Pro-Leu + 4-nitroaniline
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?
L-Ala-Gly-Gly ethyl ester + H2O
L-Ala + Gly-Gly ethyl ester
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?
L-Ala-p-nitroanilide + H2O
L-Ala + p-nitroaniline
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preferred substrate
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?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
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preferred substrate
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?
L-leucine 4-nitroanilide + H2O
L-leucine + 4-nitroaniline
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?
L-leucine-4-methylcoumaryl-7-amide + H2O
L-leucine + 7-amino-4-methylcoumarin
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?
L-leucine-7-amido-4-methylcoumarin + H2O
L-leucine + 7-amino-4-methylcoumarin
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?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
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low activity
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?
L-Phe-L-Met-D-Arg-L-Phe-NH2 + H2O
L-Phe + L-Phe-L-Met-D-Arg-NH2
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?
L-Phe-L-Met-L-Arg-L-Phe-NH2 + H2O
L-Phe + L-Phe-L-Met-L-Arg-NH2
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bioactive molluscan cardioexcitatory neuropeptide
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?
L-Tyr-7-amido-4-methylcoumarin + H2O
L-Tyr + 7-amino-4-methylcoumarin
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?
leucine enkephalin + H2O
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recombinant enzyme, release of Tyr, Gly, Phe and Leu
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?
Pro-4-nitroanilide + H2O
Pro + 4-nitroaniline
low activity
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?
QITANRELIQQEL + H2O
? + TANRELIQQEL
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intermediate product TANRELIQQEL is further processed
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?
QLESIINFEK + H2O
L-Gln + LESIINFEK
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low activity compared to other peptide substrates
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?
QLESIINFEKA + H2O
L-Gln + LESIINFEKA
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high activity compared to other peptide substrates
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?
QLESIINFEKD + H2O
L-Gln + LESIINFEKD
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low activity compared to other peptide substrates
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?
QLESIINFEKK + H2O
L-Gln + LESIINFEKK
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low activity compared to other peptide substrates
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?
QLESIINFEKL-amide + H2O
L-Gln + LESIINFEKL-amide
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high activity compared to other peptide substrates
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?
QLESIINFEKR + H2O
L-Gln + LESIINFEKR
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low activity compared to other peptide substrates
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?
QLESIINFEKY + H2O
L-Gln + LESIINFEKY
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high activity compared to other peptide substrates
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?
S-Benzoyl-Cys 4-nitroanilide + H2O
S-Benzoyl-Cys + 4-nitroaniline
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?
thionoleucine-4-anisidide + H2O
thionoleucine + anisidine
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?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
low activity
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?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
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best Xaa-4-nitroanilide substrate
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?
Ala-4-nitroanilide + H2O
Ala + 4-nitroaniline
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best Xaa-4-nitroanilide substrate
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?
Ala-Ala-Pro-Tyr-Lys-amide + H2O
Ala + Ala-Pro-Tyr-Lys-amide
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?
Ala-Ala-Pro-Tyr-Lys-amide + H2O
Ala + Ala-Pro-Tyr-Lys-amide
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?
Glu-4-nitroanilide + H2O
Glu + 4-nitroaniline
low activity
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?
Glu-Ala-Pro-Tyr-Lys-amide + H2O
Glu + Ala-Pro-Tyr-Lys-amide
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?
Glu-Ala-Pro-Tyr-Lys-amide + H2O
Glu + Ala-Pro-Tyr-Lys-amide
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?
Gly-Ala-Pro-Tyr-Lys-amide + H2O
Gly + Ala-Pro-Tyr-Lys-amide
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?
Gly-Ala-Pro-Tyr-Lys-amide + H2O
Gly + Ala-Pro-Tyr-Lys-amide
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best pentapeptide substrate
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?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
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best substrate
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?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
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?
L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala + 7-amino-4-methylcoumarin
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?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
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?
L-Arg-4-nitroanilide + H2O
L-Arg + 4-nitroaniline
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?
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
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high activity
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?
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
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?
L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg + 7-amino-4-methylcoumarin
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?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
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preferred substrate, recombinant enzyme
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?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
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substrate of the alpha-subunit, but not of the beta-subunit
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?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
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preferred substrate, recombinant enzyme
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?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
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preferred substrate
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?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
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?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
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?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
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best substrate
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?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
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best substrate
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?
L-Leu-7-amido-4-methylcoumarin + H2O
L-Leu + 7-amino-4-methylcoumarin
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efficient cleavage
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?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
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?
L-Lys-4-nitroanilide + H2O
L-Lys + 4-nitroaniline
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