Sequence of MRP4_HUMAN

ABC-type glutathione-S-conjugate transporter

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Lee K.,Belinsky M.G.,Bell D.W.,Testa J.R.,Kruh G.D.

Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter.

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Adachi M.,Sampath J.,Lan L.B.,Sun D.,Hargrove P.,Flatley R.,Tatum A.,Edwards M.Z.,Wezeman M.,Matherly L.,Drake R.,Schuetz J.

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

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Dunham A.,Matthews L.H.,Burton J.,Ashurst J.L.,Howe K.L.,Ashcroft K.J.,Beare D.M.,Burford D.C.,Hunt S.E.,Griffiths-Jones S.,Jones M.C.,Keenan S.J.,Oliver K.,Scott C.E.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews D.T.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Bannerjee R.,Barlow K.F.,Bates K.,Beasley H.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burrill W.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.E.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.C.,Cobley V.,Collins J.E.,Corby N.,Coville G.J.,Deloukas P.,Dhami P.,Dunham I.,Dunn M.,Earthrowl M.E.,Ellington A.G.,Faulkner L.,Frankish A.G.,Frankland J.,French L.,Garner P.,Garnett J.,Gilbert J.G.R.,Gilson C.J.,Ghori J.,Grafham D.V.,Gribble S.M.,Griffiths C.,Hall R.E.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Howden P.J.,Huckle E.J.,Hunt P.J.,Hunt A.R.,Johnson C.,Johnson D.,Kay M.,Kimberley A.M.,King A.,Laird G.K.,Langford C.J.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Lloyd C.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,McLaren S.J.,McMurray A.,Milne S.,Moore M.J.F.,Nickerson T.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.M.,Rice C.M.,Searle S.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Steward C.A.,Sycamore N.,Tester J.,Thomas D.W.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Wilming L.,Wray P.W.,Wright M.W.,Young L.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Beck S.,Bentley D.R.,Rogers J.,Ross M.T.

The DNA sequence and analysis of human chromosome 13.

Nature

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2004

1086360

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

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2004

1086361

Kool M.,de Haas M.,Scheffer G.L.,Scheper R.J.,van Eijk M.J.,Juijn J.A.,Baas F.,Borst P.

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

Cancer Res.

57

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1086362

Lee K.,Klein-Szanto A.J.,Kruh G.D.

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells.

J. Natl. Cancer Inst.

92

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2000

1086363

van Aubel R.A.,Smeets P.H.,Peters J.G.,Bindels R.J.,Russel F.G.

The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP.

J. Am. Soc. Nephrol.

13

595-603

2002

1086364

Rius M.,Nies A.T.,Hummel-Eisenbeiss J.,Jedlitschky G.,Keppler D.

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.

Hepatology

38

374-384

2003

1086365

Zelcer N.,Reid G.,Wielinga P.,Kuil A.,van der Heijden I.,Schuetz J.D.,Borst P.

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

Biochem. J.

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2003

1086366

Reid G.,Wielinga P.,Zelcer N.,van der Heijden I.,Kuil A.,de Haas M.,Wijnholds J.,Borst P.

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.

Proc. Natl. Acad. Sci. U.S.A.

100

9244-9249

2003

1086367

Sauna Z.E.,Nandigama K.,Ambudkar S.V.

Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.

J. Biol. Chem.

279

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2004

1086368

Van Aubel R.A.,Smeets P.H.,van den Heuvel J.J.,Russel F.G.

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

Am. J. Physiol.

288

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2005

1086369

Rius M.,Hummel-Eisenbeiss J.,Hofmann A.F.,Keppler D.

Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione.

Am. J. Physiol.

290

0-0

2006

1086370

Ci L.,Kusuhara H.,Adachi M.,Schuetz J.D.,Takeuchi K.,Sugiyama Y.

Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney.

Mol. Pharmacol.

71

1591-1597

2007

1086371

Rius M.,Hummel-Eisenbeiss J.,Keppler D.

ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4).

J. Pharmacol. Exp. Ther.

324

86-94

2008

1086372

Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Cell

127

635-648

2006

1086373

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

1086374

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

1086375

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

1086376

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

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17-17

2011

1086377

Hayashi H.,Naoi S.,Nakagawa T.,Nishikawa T.,Fukuda H.,Imajoh-Ohmi S.,Kondo A.,Kubo K.,Yabuki T.,Hattori A.,Hirouchi M.,Sugiyama Y.

Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4.

J. Biol. Chem.

287

15054-15065

2012

1086378

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

1086379

Janke D.,Mehralivand S.,Strand D.,Goedtel-Armbrust U.,Habermeier A.,Gradhand U.,Fischer C.,Toliat M.R.,Fritz P.,Zanger U.M.,Schwab M.,Fromm M.F.,Nuernberg P.,Wojnowski L.,Closs E.I.,Lang T.

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

Hum. Mutat.

29

659-669

2008

1086380

Miah M.F.,Conseil G.,Cole S.P.

N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity.

Biochem. Biophys. Res. Commun.

469

954-959

2016

1086381

Yuasa I.,Umetsu K.,Matsusue A.,Nishimukai H.,Harihara S.,Fukumori Y.,Saitou N.,Jin F.,Chattopadhyay P.K.,Henke L.,Henke J.

A Japanese-specific allele in the GALNT11 gene.

Leg. Med.

12

208-211

2010