Sequence of M2GD_RAT
EC Number:1.5.8.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
Other sequences found for EC No. 1.5.8.4
General information:
Sequence
0 MLRLGALRLR GLALRSSQGR PSSAGLREGQ ESPPSPPEWK DRAETVIIGG GCVGVSLAYH
60 LAKAGMRDVV LLEKSELTAG STWHAAGLTT YFHPGINLKK IHYDSIKLYE RLEEETGQVV
120 GFHQPGSIRL ATTPERVDEF KYQMTRTNWH ATEQYIIEPE KIHELFPLLN MDKILAGLYN
180 PGDGHIDPYS LTMALATGAR KYGVLLKYPA PVTSLKPRPD GTWDVETPQG SVRANRIVNA
240 AGFWAREVGK MIGLDHPLIP VQHQYVVTST IPEVKALKRE LPVLRDLEGS YYLRQERDGL
300 LFGPYESQEK MKLQASWVAH GVPPGFGKEL FESDLDRITE HVEAAMEMVP VLKKADIINI
360 VNGPITYSPD ILPMVGPHQG VRNYWVAIGF GYGIIHAGGV GKYLSDWILH GEPPFDLIEL
420 DPNRYGKWTT TQYTEAKARE SYGFNNIVGY PKEERFAGRP TQRVSGLYKI LESKCSMGFH
480 AGWEQPHWFY KPGQDTQYRP SFRRTNWFRP VGSEYKQVMQ RVGVIDLSPF GKFNIKGQDS
540 TQLLDHLCAN VIPKVGFTNI SHMLTPRGRV YAELTVSHQS PGEFLLITGS GSELHDLRWI
600 EEAAVRGGYD VEIRNITDEL GVLGVAGPYA RRVLQKLTSE DLSDDVFKFL QTKSLKISDI
660 PVTAIRISYT GELGWELYHR REDSAALYER IMNAGQEEGI DNFGTYALNA LRLEKAFRAW
720 GSEMNCDTNP LEAGLDYFIK LNKPADFTGK QALKQIKAKG LKRRLVCLTL ATDDVDPEGN
780 ESVWYKGKVI GNTTSGSYSY SIQKSLAFAY VPVELSEVGQ QVEVELLGKN YPATIIQEPL
840 VLTEPTRTRL QKDGRKS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1081235
Lang H.,Polster M.,Brandsch R.
Rat liver dimethylglycine dehydrogenase. Flavinylation of the enzyme in hepatocytes in primary culture and characterization of a cDNA clone.
Eur. J. Biochem.
198
793-799
1991
1081236
Cook R.J.,Misono K.S.,Wagner C.
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria.
J. Biol. Chem.
260
12998-13002
1985
1081237
Porter D.H.,Cook R.J.,Wagner C.
Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver.
Arch. Biochem. Biophys.
243
396-407
1985
1081238
Luka Z.,Pakhomova S.,Loukachevitch L.V.,Newcomer M.E.,Wagner C.
Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.
Biochem. Biophys. Res. Commun.
449
392-398
2014
