Sequence of TSUKU_STRT9
EC Number:4.2.3.159
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
tsukubadiene synthase
I2N045
Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 / 9993)
332
37389
Reaction
geranylgeranyl diphosphate = tsukubadiene + diphosphate
Other sequences found for EC No. 4.2.3.159
General information:
Sequence
show sequence in normal format
>I2N045|tsukubadiene synthase|EC 4.2.3.159|Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 / 9993)|Swiss-Prot
MIEVPPFWCPLPIAIHPAADQAEKDARAWAERYGVRLRIADQVQPGRLGAYWAPHGTYEG
MLAVGCWNFWAFAFDDHLDEPLPLDVPVTTSLVQQAVDIPSPPITDDPWAAGAQAVFNMF
RDLATPTQVRYCADNHRRWLHGACWRHSNHVNRRLPPLAEYIPLRMQDAAAQATCLIAVL
IGSDISVPEQEMDSPRVRALLETASWTATIDSDLHSFQLEDTQRPVSQHIVSVLMHERGI
GVDEALRQSVALRDRFMTRFLHLQQECARTGSSELARFAHTLGYVISGYLQWAVDTSRYG
QTEATFSFTDTPRDDTPEPPPGIPSVEWLWTL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1009834
Barreiro C.,Prieto C.,Sola-Landa A.,Solera E.,Martinez-Castro M.,Perez-Redondo R.,Garcia-Estrada C.,Aparicio J.F.,Fernandez-Martinez L.T.,Santos-Aberturas J.,Salehi-Najafabadi Z.,Rodriguez-Garcia A.,Tauch A.,Martin J.F.
Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
J. Bacteriol.
194
3756-3757
2012
1009835
Yamada Y.,Arima S.,Nagamitsu T.,Johmoto K.,Uekusa H.,Eguchi T.,Shin-ya K.,Cane D.E.,Ikeda H.
Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.
J. Antibiot.
68
385-394
2015
1009836
Rabe P.,Rinkel J.,Dolja E.,Schmitz T.,Nubbemeyer B.,Luu T.H.,Dickschat J.S.
Mechanistic investigations of two bacterial diterpene cyclases: spiroviolene synthase and tsukubadiene synthase.
Angew. Chem. Int. Ed.
56
2776-2779
2017