Sequence of 8ODP_HUMAN

2-hydroxy-dATP diphosphatase

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Sakumi K.,Furuichi M.,Tsuzuki T.,Kakuma T.,Kawabata S.,Maki H.,Sekiguchi M.

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

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893150

Furuichi M.,Yoshida M.C.,Oda H.,Tajiri T.,Nakabeppu Y.,Tsuzuki T.,Sekiguchi M.

Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.

Genomics

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485-490

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893151

Oda H.,Nakabeppu Y.,Furuichi M.,Sekiguchi M.

Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products.

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893152

Oda H.,Taketomi A.,Maruyama R.,Itoh R.,Nishioka K.,Yakushiji H.,Suzuki T.,Sekiguchi M.,Nakabeppu Y.

Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.

Nucleic Acids Res.

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893154

Scherer S.W.,Cheung J.,MacDonald J.R.,Osborne L.R.,Nakabayashi K.,Herbrick J.-A.,Carson A.R.,Parker-Katiraee L.,Skaug J.,Khaja R.,Zhang J.,Hudek A.K.,Li M.,Haddad M.,Duggan G.E.,Fernandez B.A.,Kanematsu E.,Gentles S.,Christopoulos C.C.,Choufani S.,Kwasnicka D.,Zheng X.H.,Lai Z.,Nusskern D.R.,Zhang Q.,Gu Z.,Lu F.,Zeesman S.,Nowaczyk M.J.,Teshima I.,Chitayat D.,Shuman C.,Weksberg R.,Zackai E.H.,Grebe T.A.,Cox S.R.,Kirkpatrick S.J.,Rahman N.,Friedman J.M.,Heng H.H.Q.,Pelicci P.G.,Lo-Coco F.,Belloni E.,Shaffer L.G.,Pober B.,Morton C.C.,Gusella J.F.,Bruns G.A.P.,Korf B.R.,Quade B.J.,Ligon A.H.,Ferguson H.,Higgins A.W.,Leach N.T.,Herrick S.R.,Lemyre E.,Farra C.G.,Kim H.-G.,Summers A.M.,Gripp K.W.,Roberts W.,Szatmari P.,Winsor E.J.T.,Grzeschik K.-H.,Teebi A.,Minassian B.A.,Kere J.,Armengol L.,Pujana M.A.,Estivill X.,Wilson M.D.,Koop B.F.,Tosi S.,Moore G.E.,Boright A.P.,Zlotorynski E.,Kerem B.,Kroisel P.M.,Petek E.,Oscier D.G.,Mould S.J.,Doehner H.,Doehner K.,Rommens J.M.,Vincent J.B.,Venter J.C.,Li P.W.,Mural R.J.,Adams M.D.,Tsui L.-C.

Human chromosome 7: DNA sequence and biology.

Science

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767-772

2003

893157

Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.

The DNA sequence of human chromosome 7.

Nature

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157-164

2003

893158

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

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2004

893159

Kang D.,Nishida J.,Iyama A.,Nakabeppu Y.,Furuichi M.,Fujiwara T.,Sekiguchi M.,Takeshige K.

Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria.

J. Biol. Chem.

270

14659-14665

1995

893160

Fujikawa K.,Kamiya H.,Yakushiji H.,Fujii Y.,Nakabeppu Y.,Kasai H.

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.

J. Biol. Chem.

274

18201-18205

1999

893161

Fujii Y.,Shimokawa H.,Sekiguchi M.,Nakabeppu Y.

Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins.

J. Biol. Chem.

274

38251-38259

1999

893162

Fujikawa K.,Kamiya H.,Yakushiji H.,Nakabeppu Y.,Kasai H.

Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.

Nucleic Acids Res.

29

449-454

2001

893163

Sakai Y.,Furuichi M.,Takahashi M.,Mishima M.,Iwai S.,Shirakawa M.,Nakabeppu Y.

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.

J. Biol. Chem.

277

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2002

893164

Yoshimura D.,Sakumi K.,Ohno M.,Sakai Y.,Furuichi M.,Iwai S.,Nakabeppu Y.

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress.

J. Biol. Chem.

278

37965-37973

2003

893165

Sakai Y.,Oda H.,Yoshimura D.,Furuichi M.,Kang D.,Iwai S.,Hara T.,Nakabeppu Y.

The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.

J. Mol. Med.

84

660-670

2006

893166

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

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17-17

2011

893167

Takagi Y.,Setoyama D.,Ito R.,Kamiya H.,Yamagata Y.,Sekiguchi M.

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.

J. Biol. Chem.

287

21541-21549

2012

893168

Carter M.,Jemth A.S.,Hagenkort A.,Page B.D.,Gustafsson R.,Griese J.J.,Gad H.,Valerie N.C.,Desroses M.,Bostrom J.,Warpman Berglund U.,Helleday T.,Stenmark P.

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

Nat. Commun.

6

7871-7871

2015

893169

Mishima M.,Sakai Y.,Itoh N.,Kamiya H.,Furuichi M.,Takahashi M.,Yamagata Y.,Iwai S.,Nakabeppu Y.,Shirakawa M.

Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.

J. Biol. Chem.

279

33806-33815

2004

893170

Nakamura T.,Kitaguchi Y.,Miyazawa M.,Kamiya H.,Toma S.,Ikemizu S.,Shirakawa M.,Nakabeppu Y.,Yamagata Y.

Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.

Acta Crystallogr. F

62

1283-1285

2006

893171

Svensson L.M.,Jemth A.S.,Desroses M.,Loseva O.,Helleday T.,Hogbom M.,Stenmark P.

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.

FEBS Lett.

585

2617-2621

2011

893173

Gad H.,Koolmeister T.,Jemth A.S.,Eshtad S.,Jacques S.A.,Strom C.E.,Svensson L.M.,Schultz N.,Lundback T.,Einarsdottir B.O.,Saleh A.,Gokturk C.,Baranczewski P.,Svensson R.,Berntsson R.P.,Gustafsson R.,Stromberg K.,Sanjiv K.,Jacques-Cordonnier M.C.,Desroses M.,Gustavsson A.L.,Olofsson R.,Johansson F.,Homan E.J.,Loseva O.,Brautigam L.,Johansson L.,Hoglund A.,Hagenkort A.,Pham T.,Altun M.,Gaugaz F.Z.,Vikingsson S.,Evers B.,Henriksson M.,Vallin K.S.,Wallner O.A.,Hammarstrom L.G.,Wiita E.,Almlof I.,Kalderen C.,Axelsson H.,Djureinovic T.,Puigvert J.C.,Haggblad M.,Jeppsson F.,Martens U.,Lundin C.,Lundgren B.,Granelli I.,Jensen A.J.,Artursson P.,Nilsson J.A.,Stenmark P.,Scobie M.,Berglund U.W.,Helleday T.

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Nature

508

215-221

2014

893174

Huber K.V.,Salah E.,Radic B.,Gridling M.,Elkins J.M.,Stukalov A.,Jemth A.S.,Gokturk C.,Sanjiv K.,Stromberg K.,Pham T.,Berglund U.W.,Colinge J.,Bennett K.L.,Loizou J.I.,Helleday T.,Knapp S.,Superti-Furga G.

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Nature

508

222-227

2014

893175

Nissink J.W.,Bista M.,Breed J.,Carter N.,Embrey K.,Read J.,Winter-Holt J.J.

MTH1 Substrate Recognition--An Example of Specific Promiscuity.

PLoS ONE

11

0-0

2016

893176

Ellermann M.,Eheim A.,Rahm F.,Viklund J.,Guenther J.,Andersson M.,Ericsson U.,Forsblom R.,Ginman T.,Lindstrom J.,Silvander C.,Tresaugues L.,Giese A.,Bunse S.,Neuhaus R.,Weiske J.,Quanz M.,Glasauer A.,Nowak-Reppel K.,Bader B.,Irlbacher H.,Meyer H.,Queisser N.,Bauser M.,Haegebarth A.,Gorjanacz M.

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.

ACS Chem. Biol.

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2017

893177

Waz S.,Nakamura T.,Hirata K.,Koga-Ogawa Y.,Chirifu M.,Arimori T.,Tamada T.,Ikemizu S.,Nakabeppu Y.,Yamagata Y.

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.

J. Biol. Chem.

292

2785-2794

2017

893178

Jemth A.S.,Gustafsson R.,Braeutigam L.,Henriksson L.,Vallin K.S.A.,Sarno A.,Almloef I.,Homan E.,Rasti A.,Warpman Berglund U.,Stenmark P.,Helleday T.

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.

Nucleic Acids Res.

46

10888-10904

2018

893179

Scaletti E.R.,Vallin K.S.,Braeutigam L.,Sarno A.,Warpman Berglund U.,Helleday T.,Stenmark P.,Jemth A.S.

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

J. Biol. Chem.

295

4761-4772

2020

893180

Miyako K.,Kohno H.,Ihara K.,Kuromaru R.,Matsuura N.,Hara T.

Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus.

Endocr. J.

51

493-498

2004

893181

Kohno T.,Sakiyama T.,Kunitoh H.,Goto K.,Nishiwaki Y.,Saito D.,Hirose H.,Eguchi T.,Yanagitani N.,Saito R.,Sasaki-Matsumura R.,Mimaki S.,Toyama K.,Yamamoto S.,Kuchiba A.,Sobue T.,Ohta T.,Ohki M.,Yokota J.

Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk.

Carcinogenesis

27

2448-2454

2006