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Information on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase
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3.6.1.56 2-hydroxy-dATP diphosphataseIUBMB Comments
The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) .
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Word Map
- 3.6.1.56
-
mutt
- triphosphates
- glycosylase
-
8-oxo-dg
-
sanitization
- 8-oxo-2'-deoxyguanosine
- 8-oxodgtp
- 8-oxo-dgtpase
- dgtp
-
hnpcc
-
2-oh-datp
-
8-ohdg
-
8-hydroxy-2'-deoxyguanosine
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
hmth1, nudix hydrolase 2, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
MTH1
MutT homologue 1
NUDT1
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
2-hydroxy-dATP diphosphohydrolase
The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [3].
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
8-oxo-GDP + H2O
8-oxo-GMP + phosphate
-
Vmax/Km is 4% of the value for 8-oxo-GTP
-
-
?
2-hydroxy-ATP + H2O
2-hydroxy-AMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration
-
-
?
2-hydroxy-dATP + 2 H2O
2-hydroxy-dAMP + 2 phosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
-
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
human MTH1 hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-oxo-dATP, to monophosphates, thereby preventing the misincorporation of these oxidized nucleotides during replication
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP. These alterations may be partly attributed to a mitochondrial dysfunction
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
-
hydrolyzed more efficiently and with higher affinity than 8-oxo-dATP. Preferential hydrolysis of 2-oxo-dATP over 8-oxo-dGTP is observed at all of the pH values tested (pH 7.2 to pH 8.8). A 5fold difference in the hydrolysis efficiencies for 2-oxo-dATP over 8-oxo-dGTP is found at pH 7.2. In addition to the normal form of hMTH1 (valine 83), the variant form of the protein (methionine 83) also hydrolyzes 2-oxo-dATP more efficiently than 8-oxo-dGTP
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
-
is more efficiently hydrolyzed to the monophosphate than is 8-oxo-dGTP
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
is more efficiently hydrolyzed to the monophosphate than is 8-oxo-dGTP
-
-
?
8-oxo-dATP + H2O
8-oxo-dAMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration
-
-
?
8-oxo-dATP + H2O
8-oxo-dAMP + diphosphate
-
hydrolyzed as efficiently as 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate is produced during cellular metabolism, and its misincorporation into DNA causes mutation. MTH1 hydrolyzes 8-oxo-dGTP to the corresponding nucleoside monophosphate, thereby preventing misincorporation of 8-oxo-7,8-dihydroguanine into DNA. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
human MTH1 hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-oxo-dATP, to monophosphates, thereby preventing the misincorporation of these oxidized nucleotides during replication. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
the enzyme is responsible for preventing misincorporation of 8-oxoguanine into DNA. The enzyme protects genetic information from the untoward effects of endogenous oxygen radicals. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP. Trp117 is essential for MTH1 to recognize both 8-oxodGTP and 2-hydroxy-dATP, whereas Asp119 is only essential for recognizing 2-hydroxy-dATP, thus suggesting that origins of the substrate-binding pockets for MTH1 and MutT (from Escherichia coli) are different
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
MTH1 catalyzes hydrolysis of 8-oxo-dGTP through nucleophilic substitution of water at the beta-phosphate. The side chains of Asp119 and Asn33 play an essential role in 2-OH-dATP recognition, whereas the indole ring of Trp117 may be important for interacting with the purine bases of substrate nucleotides. Solution structure of MTH1 solved by multidimensional heteronuclear NMR spectroscopy, identification of the substrate interaction pocket. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. The MTH2 protein prevents mutations caused by 8-oxoguanine nucleotides. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
highest specific activity toward 8-oxo-dGTP
-
-
?
8-oxo-GTP + H2O
8-oxo-GMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
8-oxo-GTP + H2O
8-oxo-GMP + diphosphate
-
this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-GTP + H2O
8-oxo-GMP + diphosphate
-
the MTH1 protein has the ability to cleave the phosphoanhydride bond between the alpha and the beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-GTP + H2O
8-oxo-GMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
additional information
?
-
-
no hydrolysis of (R)-8,5'-cyclodATP, 5-oxo-dCTP, and 5-formyl-dUTP
-
-
?
additional information
?
-
-
Vmax/Km for GDP is 0.3% of the value for 8-oxo-GTP
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxy-ATP + H2O
2-hydroxy-AMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration
-
-
?
2-hydroxy-dATP + 2 H2O
2-hydroxy-dAMP + 2 phosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively
-
-
?
8-oxo-GTP + H2O
8-oxo-GMP + diphosphate
-
this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
human MTH1 hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-oxo-dATP, to monophosphates, thereby preventing the misincorporation of these oxidized nucleotides during replication
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP. These alterations may be partly attributed to a mitochondrial dysfunction
-
-
?
8-oxo-dATP + H2O
8-oxo-dAMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate is produced during cellular metabolism, and its misincorporation into DNA causes mutation. MTH1 hydrolyzes 8-oxo-dGTP to the corresponding nucleoside monophosphate, thereby preventing misincorporation of 8-oxo-7,8-dihydroguanine into DNA. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy-ATP to monophosphates, and thus avoids errors caused by their misincorporation during DNA replication or transcription, which may result in carcinogenesis or neurodegeneration. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
human MTH1 hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-oxo-dATP, to monophosphates, thereby preventing the misincorporation of these oxidized nucleotides during replication. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
the enzyme is responsible for preventing misincorporation of 8-oxoguanine into DNA. The enzyme protects genetic information from the untoward effects of endogenous oxygen radicals. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
-
Co2+ (5 mM) stimulates most enzyme hydrolase activities, with the exception of 8-oxo-dATP and Ap4A
Mg2+
-
5 mm Mg2+ is not effective in stimulating enzyme-mediated 8-oxo-dATP, ATP, and Ap4A hydrolysis, however, 5 mM Mg2+ is the most effective in hydrolysing dADP and dGDP
Mn2+
-
most effective cofactor. The optimal concentrations of Mn2+ for enzyme activity toward 8-oxo-dGTP and dGTP are 0.25 mM and 0.75 mM, respectively
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-hydroxy-dADP
-
competitively inhibits both the 2-hydroxy-dATP hydrolase and 8-hydroxy-dGTP hydrolase activities of hMTH1
2-hydroxy-dATP
the hydrolysis of 8-oxo-dGTP (0.01 mM) by wild type and F27A decreases to 42% and 44% of the control in the presence of 0.01 mM 2-hydroxy-dATP. 8-oxo-dGTPase activities of D119A and D119N mutants are not altered in the presence of 2-hydroxy-dATP up to 0.1 mM
2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
i.e. SCH-51344
8-oxo-dGDP
-
competitively inhibits both the 2-hydroxy-dATP hydrolase and 8-hydroxy-dGTP hydrolase activities of hMTH1
dATP
the 8-oxo-dGTPase activity of wild type hMTH1 decreases to 79.6% of the control in the presence of 0.1 mM dATP
N-[3-[(propan-2-yl)oxy]propyl]-9H-purin-6-amine
NPD15095, competitive inhibition
8-oxo-dGTP
the hydrolysis of 2-hydroxy-dATP (0.01 mM) by wild type hMTH1 is inhibited to 50% of the control in the presence of 0.017 mM 8-oxo-dGTP, whereas the W117Y mutant efficiently hydrolyzes 2-hydroxy-dATP even in the presence of 0.1 mM 8-oxodGTP and its initial velocity is 57% of the control
N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine
i.e. TH588
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
2-hydroxy-datp diphosphatase deficiency
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
Adenoma
HMTH1 induces the metastasis and recurrence of the parotid adenoma by repairing DNA damage.
Alzheimer Disease
Expression of hMTH1 in the hippocampi of control and Alzheimer's disease.
Brain Neoplasms
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Brain Neoplasms
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Breast Neoplasms
Biological characterisation and application of human MTH1 and monoclonal antibody preparation.
Breast Neoplasms
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Carcinoma
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Carcinoma
Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer.
Carcinoma, Hepatocellular
Expression of DNA repair enzyme hMTH1 mRNA and protein in hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Potential role of human DNA-repair enzymes hMTH1, hOGG1 and hMYHalpha in the hepatocarcinogenesis]
Carcinoma, Non-Small-Cell Lung
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Carcinoma, Non-Small-Cell Lung
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Carcinoma, Renal Cell
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Colorectal Neoplasms
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
Colorectal Neoplasms
The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells.
Colorectal Neoplasms, Hereditary Nonpolyposis
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
Diabetes Mellitus, Type 2
Combined analysis of polymorphism variants in hMTH1, hOGG1 and MUTYH genes on the risk of type 2 diabetes in the Chinese population.
Dystonia
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.
Glioma
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Huntington Disease
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.
Idiopathic Pulmonary Fibrosis
Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.
Leukemia
Inhibition of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity of the antimutagenic human MTH1 protein by nucleoside 5'-diphosphates.
Lung Diseases, Interstitial
Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.
Lung Neoplasms
Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients.
Lung Neoplasms
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Lung Neoplasms
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Lung Neoplasms
Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells.
Lymphatic Metastasis
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Meningioma
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Neoplasm Metastasis
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Neoplasm Metastasis
HMTH1 induces the metastasis and recurrence of the parotid adenoma by repairing DNA damage.
Neoplasm Metastasis
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.
Neoplasms
A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients.
Neoplasms
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Neoplasms
Bacterial DNA repair genes and their eukaryotic homologues: 2. Role of bacterial mutator gene homologues in human disease. Overview of nucleotide pool sanitization and mismatch repair systems.
Neoplasms
Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients.
Neoplasms
Expression of DNA repair enzyme hMTH1 mRNA and protein in hepatocellular carcinoma.
Neoplasms
Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers.
Neoplasms
Hexabromocyclododecane-induced Genotoxicity in Cultured Human Breast Cells through DNA Damage.
Neoplasms
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
Neoplasms
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.
Neoplasms
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Neoplasms
Inhibitory Effect of 8-Halogenated 7-Deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.
Neoplasms
Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer.
Neoplasms
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
Neoplasms
Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.
Neoplasms, Neuroepithelial
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Neurilemmoma
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Stomach Neoplasms
A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients.
Thyroid Neoplasms
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
Thyroid Neoplasms
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0134
2-hydroxy-rATP
at pH 7.4, temperature not specified in the publication
0.014
2-hydroxy-dATP
at pH 7.4, temperature not specified in the publication