Sequence of KPCI_HUMAN
EC Number:2.7.11.13
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.13
General information:
Sequence
0 MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF
60 DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE
120 DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK
180 KCHKLVTIEC GRHSLPQEPV MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR
240 ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ
300 TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA
360 EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI
420 APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR
480 IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK
540 PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
817264
Selbie L.A.,Schmitz-Peiffer C.,Sheng Y.,Biden T.J.
Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.
J. Biol. Chem.
268
24296-24302
1993
817265
Mazzarella R.,Ciccodicola A.,Esposito T.,Arcucci A.,Migliaccio C.,Jones C.,Schlessinger D.,D'Urso M.,D'Esposito M.
Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.
Genomics
26
629-631
1995
817267
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
817268
Diaz-Meco M.T.,Municio M.M.,Sanchez P.,Lozano J.,Moscat J.
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.
Mol. Cell. Biol.
16
105-114
1996
817269
Murray N.R.,Fields A.P.
Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis.
J. Biol. Chem.
272
27521-27524
1997
817270
Sanchez P.,De Carcer G.,Sandoval I.V.,Moscat J.,Diaz-Meco M.T.
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.
Mol. Cell. Biol.
18
3069-3080
1998
817271
Wooten M.W.,Seibenhener M.L.,Zhou G.,Vandenplas M.L.,Tan T.H.
Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway.
Cell Death Differ.
6
753-764
1999
817272
Sanz L.,Sanchez P.,Lallena M.-J.,Diaz-Meco M.T.,Moscat J.
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
EMBO J.
18
3044-3053
1999
817273
Spitaler M.,Villunger A.,Grunicke H.,Uberall F.
Unique structural and functional properties of the ATP-binding domain of atypical protein kinase C-iota.
J. Biol. Chem.
275
33289-33296
2000
817274
Xie J.,Guo Q.,Zhu H.,Wooten M.W.,Mattson M.P.
Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide.
Brain Res. Mol. Brain Res.
82
107-113
2000
817275
Noda Y.,Takeya R.,Ohno S.,Naito S.,Ito T.,Sumimoto H.
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
Genes Cells
6
107-119
2001
817276
Suzuki A.,Yamanaka T.,Hirose T.,Manabe N.,Mizuno K.,Shimizu M.,Akimoto K.,Izumi Y.,Ohnishi T.,Ohno S.
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.
J. Cell Biol.
152
1183-1196
2001
817277
Tisdale E.J.
Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway.
J. Biol. Chem.
277
3334-3341
2002
817278
Wooten M.W.,Vandenplas M.L.,Seibenhener M.L.,Geetha T.,Diaz-Meco M.T.
Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.
Mol. Cell. Biol.
21
8414-8427
2001
817279
White W.O.,Seibenhener M.L.,Wooten M.W.
Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C.
J. Cell. Biochem.
85
42-53
2002
817280
Zemlickova E.,Dubois T.,Kerai P.,Clokie S.,Cronshaw A.D.,Wakefield R.I.D.,Johannes F.-J.,Aitken A.
Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.
Biochem. Biophys. Res. Commun.
307
459-465
2003
817281
Yamanaka T.,Horikoshi Y.,Sugiyama Y.,Ishiyama C.,Suzuki A.,Hirose T.,Iwamatsu A.,Shinohara A.,Ohno S.
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.
Curr. Biol.
13
734-743
2003
817282
Tisdale E.J.,Wang J.,Silver R.B.,Artalejo C.R.
Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates.
J. Biol. Chem.
278
38015-38021
2003
817283
Tisdale E.J.
Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.
J. Biol. Chem.
278
52524-52530
2003
817284
Mamidipudi V.,Lin C.,Seibenhener M.L.,Wooten M.W.
Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C.
J. Biol. Chem.
279
4161-4165
2004
817285
Regala R.P.,Weems C.,Jamieson L.,Copland J.A.,Thompson E.A.,Fields A.P.
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.
J. Biol. Chem.
280
31109-31115
2005
817286
Bicaku E.,Patel R.,Acevedo-Duncan M.
Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.
Tissue Cell
37
53-58
2005
817287
Fritzius T.,Burkard G.,Haas E.,Heinrich J.,Schweneker M.,Bosse M.,Zimmermann S.,Frey A.D.,Caelers A.,Bachmann A.S.,Moelling K.
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
Biochem. J.
399
9-20
2006
817288
Tisdale E.J.,Artalejo C.R.
Src-dependent protein kinase C iota/lambda (aPKCiota/lambda) tyrosine phosphorylation is required for aPKCiota/lambda association with Rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-Golgi intermediates.
J. Biol. Chem.
281
8436-8442
2006
817289
Fritzius T.,Frey A.D.,Schweneker M.,Mayer D.,Moelling K.
WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.
FEBS J.
274
1552-1566
2007
817290
Wald F.A.,Oriolo A.S.,Mashukova A.,Fregien N.L.,Langshaw A.H.,Salas P.J.
Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells.
J. Cell Sci.
121
644-654
2008
817291
Cantin G.T.,Yi W.,Lu B.,Park S.K.,Xu T.,Lee J.-D.,Yates J.R. III
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
J. Proteome Res.
7
1346-1351
2008
817292
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
817293
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
817294
Staiger K.,Schatz U.,Staiger H.,Weyrich P.,Haas C.,Guirguis A.,Machicao F.,Haering H.U.,Kellerer M.
Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.
Microvasc. Res.
78
40-44
2009
817295
Justilien V.,Fields A.P.
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.
Oncogene
28
3597-3607
2009
817296
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
817297
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
817298
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
817299
Desai S.,Pillai P.,Win-Piazza H.,Acevedo-Duncan M.
PKC-? promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.
Biochim. Biophys. Acta
1813
1190-1197
2011
817300
Justilien V.,Jameison L.,Der C.J.,Rossman K.L.,Fields A.P.
Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.
J. Biol. Chem.
286
8149-8157
2011
817301
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
817302
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
817303
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
817304
Hirano Y.,Yoshinaga S.,Ogura K.,Yokochi M.,Noda Y.,Sumimoto H.,Inagaki F.
Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5.
J. Biol. Chem.
279
31883-31890
2004
817305
Hirano Y.,Yoshinaga S.,Takeya R.,Suzuki N.N.,Horiuchi M.,Kohjima M.,Sumimoto H.,Inagaki F.
Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.
J. Biol. Chem.
280
9653-9661
2005
817306
Messerschmidt A.,Macieira S.,Velarde M.,Baedeker M.,Benda C.,Jestel A.,Brandstetter H.,Neuefeind T.,Blaesse M.
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
J. Mol. Biol.
352
918-931
2005
817307
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
