Sequence of PLK4_HUMAN

polo kinase

O00444

970

108972

713579

Yamashita Y.,Kajigaya S.,Yoshida K.,Ueno S.,Ota J.,Ohmine K.,Ueda M.,Miyazato A.,Ohya K.,Kitamura T.,Ozawa K.,Mano H.

Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase.

J. Biol. Chem.

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713580

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

713581

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

713582

Mills G.B.,Schmandt R.,Gibson S.,Leung B.,Hill M.,May C.,Shi Y.F.,Branch D.R.,Radvanyi L.,Truitt K.E.,Imboden J.

Transmembrane signaling by the interleukin-2 receptor: progress and conundrums.

Semin. Immunol.

5

345-364

1993

713583

Lehtola L.,Partanen J.,Sistonen L.,Korhonen J.,Warri A.,Harkonen P.,Clarke R.,Alitalo K.

Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.

Int. J. Cancer

50

598-603

1992

713584

Bettencourt-Dias M.,Rodrigues-Martins A.,Carpenter L.,Riparbelli M.,Lehmann L.,Gatt M.K.,Carmo N.,Balloux F.,Callaini G.,Glover D.M.

SAK/PLK4 is required for centriole duplication and flagella development.

Curr. Biol.

15

2199-2207

2005

713585

Habedanck R.,Stierhof Y.-D.,Wilkinson C.J.,Nigg E.A.

The Polo kinase Plk4 functions in centriole duplication.

Nat. Cell Biol.

7

1140-1146

2005

713586

Li J.,Tan M.,Li L.,Pamarthy D.,Lawrence T.S.,Sun Y.

SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing.

Neoplasia

7

312-323

2005

713587

Kleylein-Sohn J.,Westendorf J.,Le Clech M.,Habedanck R.,Stierhof Y.-D.,Nigg E.A.

Plk4-induced centriole biogenesis in human cells.

Dev. Cell

13

190-202

2007

713588

Bonni S.,Ganuelas M.L.,Petrinac S.,Hudson J.W.

Human Plk4 phosphorylates Cdc25C.

Cell Cycle

7

545-547

2008

713589

Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

Mol. Cell

31

438-448

2008

713590

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

713591

Petrinac S.,Ganuelas M.L.,Bonni S.,Nantais J.,Hudson J.W.

Polo-like kinase 4 phosphorylates Chk2.

Cell Cycle

8

327-329

2009

713592

Kuriyama R.,Bettencourt-Dias M.,Hoffmann I.,Arnold M.,Sandvig L.

Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells.

J. Cell Sci.

122

2014-2023

2009

713593

Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.

Large-scale proteomics analysis of the human kinome.

Mol. Cell. Proteomics

8

1751-1764

2009

713594

Cizmecioglu O.,Arnold M.,Bahtz R.,Settele F.,Ehret L.,Haselmann-Weiss U.,Antony C.,Hoffmann I.

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.

J. Cell Biol.

191

731-739

2010

713595

Dzhindzhev N.S.,Yu Q.D.,Weiskopf K.,Tzolovsky G.,Cunha-Ferreira I.,Riparbelli M.,Rodrigues-Martins A.,Bettencourt-Dias M.,Callaini G.,Glover D.M.

Asterless is a scaffold for the onset of centriole assembly.

Nature

467

714-718

2010

713596

Tang C.J.,Lin S.Y.,Hsu W.B.,Lin Y.N.,Wu C.T.,Lin Y.C.,Chang C.W.,Wu K.S.,Tang T.K.

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.

EMBO J.

30

4790-4804

2011

713597

Puklowski A.,Homsi Y.,Keller D.,May M.,Chauhan S.,Kossatz U.,Grunwald V.,Kubicka S.,Pich A.,Manns M.P.,Hoffmann I.,Gonczy P.,Malek N.P.

The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.

Nat. Cell Biol.

13

1004-1009

2011

713598

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

713599

Martin C.A.,Ahmad I.,Klingseisen A.,Hussain M.S.,Bicknell L.S.,Leitch A.,Nuernberg G.,Toliat M.R.,Murray J.E.,Hunt D.,Khan F.,Ali Z.,Tinschert S.,Ding J.,Keith C.,Harley M.E.,Heyn P.,Mueller R.,Hoffmann I.,Daire V.C.,Dollfus H.,Dupuis L.,Bashamboo A.,McElreavey K.,Kariminejad A.,Mendoza-Londono R.,Moore A.T.,Saggar A.,Schlechter C.,Weleber R.,Thiele H.,Altmueller J.,Hoehne W.,Hurles M.E.,Noegel A.A.,Baig S.M.,Nuernberg P.,Jackson A.P.

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.

Nat. Genet.

46

1283-1292

2014

713600

Brunk K.,Zhu M.,Baerenz F.,Kratz A.S.,Haselmann-Weiss U.,Antony C.,Hoffmann I.

Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication.

J. Cell Sci.

129

2713-2718

2016

713601

Fournier M.,Orpinell M.,Grauffel C.,Scheer E.,Garnier J.M.,Ye T.,Chavant V.,Joint M.,Esashi F.,Dejaegere A.,Goenczy P.,Tora L.

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

Nat. Commun.

7

13227-13227

2016

713602

Denu R.A.,Sass M.M.,Johnson J.M.,Potts G.K.,Choudhary A.,Coon J.J.,Burkard M.E.

Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).

J. Biol. Chem.

294

6531-6549

2019

713603

Chen H.,Lu D.,Shang G.,Gao G.,Zhang X.

Structural and Functional Analyses of the FAM46C/Plk4 Complex.

Structure

28

910-0

2020

713605

Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.

Patterns of somatic mutation in human cancer genomes.

Nature

446

153-158

2007