Sequence of PDE3A_HUMAN
EC Number:3.1.4.17
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate
Other sequences found for EC No. 3.1.4.17
General information:
Sequence
0 MAVPGDAARV RDKPVHSGVS QAPTAGRDCH HRADPASPRD SGCRGCWGDL VLQPLRSSRK
60 LSSALCAGSL SFLLALLVRL VRGEVGCDLE QCKEAAAAEE EEAAPGAEGG VFPGPRGGAP
120 GGGARLSPWL QPSALLFSLL CAFFWMGLYL LRAGVRLPLA VALLAACCGG EALVQIGLGV
180 GEDHLLSLPA AGVVLSCLAA ATWLVLRLRL GVLMIALTSA VRTVSLISLE RFKVAWRPYL
240 AYLAGVLGIL LARYVEQILP QSAEAAPREH LGSQLIAGTK EDIPVFKRRR RSSSVVSAEM
300 SGCSSKSHRR TSLPCIPREQ LMGHSEWDHK RGPRGSQSSG TSITVDIAVM GEAHGLITDL
360 LADPSLPPNV CTSLRAVSNL LSTQLTFQAI HKPRVNPVTS LSENYTCSDS EESSEKDKLA
420 IPKRLRRSLP PGLLRRVSST WTTTTSATGL PTLEPAPVRR DRSTSIKLQE APSSSPDSWN
480 NPVMMTLTKS RSFTSSYAIS AANHVKAKKQ SRPGALAKIS PLSSPCSSPL QGTPASSLVS
540 KISAVQFPES ADTTAKQSLG SHRALTYTQS APDLSPQILT PPVICSSCGR PYSQGNPADE
600 PLERSGVATR TPSRTDDTAQ VTSDYETNNN SDSSDIVQNE DETECLREPL RKASACSTYA
660 PETMMFLDKP ILAPEPLVMD NLDSIMEQLN TWNFPIFDLV ENIGRKCGRI LSQVSYRLFE
720 DMGLFEAFKI PIREFMNYFH ALEIGYRDIP YHNRIHATDV LHAVWYLTTQ PIPGLSTVIN
780 DHGSTSDSDS DSGFTHGHMG YVFSKTYNVT DDKYGCLSGN IPALELMALY VAAAMHDYDH
840 PGRTNAFLVA TSAPQAVLYN DRSVLENHHA AAAWNLFMSR PEYNFLINLD HVEFKHFRFL
900 VIEAILATDL KKHFDFVAKF NGKVNDDVGI DWTNENDRLL VCQMCIKLAD INGPAKCKEL
960 HLQWTDGIVN EFYEQGDEEA SLGLPISPFM DRSAPQLANL QESFISHIVG PLCNSYDSAG
1020 LMPGKWVEDS DESGDTDDPE EEEEEAPAPN EEETCENNES PKKKTFKRRK IYCQITQHLL
1080 QNHKMWKKVI EEEQRLAGIE NQSLDQTPQS HSSEQIQAIK EEEEEKGKPR GEEIPTQKPD
1140 Q
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
710578
Meacci E.,Taira M.,Moos M. Jr.,Smith C.J.,Movsesian M.A.,Degerman E.,Belfrage P.,Manganiello V.
Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.
Proc. Natl. Acad. Sci. U.S.A.
89
3721-3725
1992
710580
Cheung P.P.,Xu H.,McLaughlin M.M.,Ghazaleh F.A.,Livi G.P.,Colman R.W.
Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis.
Blood
88
1321-1329
1996
710581
Kuthe A.,Eckel H.,Stief C.G.,Uckert S.,Forssmann W.-G.,Jonas U.,Maegert H.-J.
Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum.
Chem. Biol. Interact.
119
593-598
1999
710582
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
710583
Degerman E.,Moos M. Jr.,Rascon A.,Vasta V.,Meacci E.,Smith C.J.,Lindgren S.,Andersson K.-E.,Belfrage P.,Manganiello V.
Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase.
Biochim. Biophys. Acta
1205
189-198
1994
710584
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
710585
Zahedi R.P.,Lewandrowski U.,Wiesner J.,Wortelkamp S.,Moebius J.,Schuetz C.,Walter U.,Gambaryan S.,Sickmann A.
Phosphoproteome of resting human platelets.
J. Proteome Res.
7
526-534
2008
710586
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
710587
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
710588
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
710589
Maass P.G.,Aydin A.,Luft F.C.,Schaechterle C.,Weise A.,Stricker S.,Lindschau C.,Vaegler M.,Qadri F.,Toka H.R.,Schulz H.,Krawitz P.M.,Parkhomchuk D.,Hecht J.,Hollfinger I.,Wefeld-Neuenfeld Y.,Bartels-Klein E.,Muehl A.,Kann M.,Schuster H.,Chitayat D.,Bialer M.G.,Wienker T.F.,Ott J.,Rittscher K.,Liehr T.,Jordan J.,Plessis G.,Tank J.,Mai K.,Naraghi R.,Hodge R.,Hopp M.,Hattenbach L.O.,Busjahn A.,Rauch A.,Vandeput F.,Gong M.,Rueschendorf F.,Huebner N.,Haller H.,Mundlos S.,Bilginturan N.,Movsesian M.A.,Klussmann E.,Toka O.,Baehring S.
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Nat. Genet.
47
647-653
2015
710590
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
710591
Berrisch S.,Ostermeyer J.,Kaever V.,Kaelble S.,Hilfiker-Kleiner D.,Seifert R.,Schneider E.H.
cUMP hydrolysis by PDE3A.
Naunyn Schmiedebergs Arch. Pharmacol.
390
269-280
2017
710592
Li D.,Chen J.,Ai Y.,Gu X.,Li L.,Che D.,Jiang Z.,Li L.,Chen S.,Huang H.,Wang J.,Cai T.,Cao Y.,Qi X.,Wang X.
Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover.
Mol. Cell
75
1103-1116
2019
710593
Yan B.,Ding Z.,Zhang W.,Cai G.,Han H.,Ma Y.,Cao Y.,Wang J.,Chen S.,Ai Y.
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death.
Cell Chem. Biol.
0
0-0
2022
710594
Garvie C.W.,Wu X.,Papanastasiou M.,Lee S.,Fuller J.,Schnitzler G.R.,Horner S.W.,Baker A.,Zhang T.,Mullahoo J.P.,Westlake L.,Hoyt S.H.,Toetzl M.,Ranaghan M.J.,de Waal L.,McGaunn J.,Kaplan B.,Piccioni F.,Yang X.,Lange M.,Tersteegen A.,Raymond D.,Lewis T.A.,Carr S.A.,Cherniack A.D.,Lemke C.T.,Meyerson M.,Greulich H.
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat. Commun.
12
4375-4375
2021
710595
Chen J.,Liu N.,Huang Y.,Wang Y.,Sun Y.,Wu Q.,Li D.,Gao S.,Wang H.W.,Huang N.,Qi X.,Wang X.
Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells.
Nat. Commun.
12
6204-6204
2021
