Sequence of GSHR_HUMAN
EC Number:1.8.1.7
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
Other sequences found for EC No. 1.8.1.7
General information:
Sequence
0 MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP QPQGPPPAAG
60 AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS
120 EFMHDHADYG FPSCEGKFNW RVIKEKRDAY VSRLNAIYQN NLTKSHIEII RGHAAFTSDP
180 KPTIEVSGKK YTAPHILIAT GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG
240 YIAVEMAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
300 TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ TDDKGHIIVD
360 EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY KEDSKLDYNN IPTVVFSHPP
420 IGTVGLTEDE AIHKYGIENV KTYSTSFTPM YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ
480 GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVT LR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
678577
Tutic M.,Lu X.A.,Schirmer R.H.,Werner D.
Cloning and sequencing of mammalian glutathione reductase cDNA.
Eur. J. Biochem.
188
523-528
1990
678578
Kelner M.J.,Montoya M.A.
Structural organization of the human glutathione reductase (GSR) gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence.
Biochem. Biophys. Res. Commun.
269
366-368
2000
678580
Satoh N.,Watanabe N.,Kanda A.,Sugaya-Fukazawa M.,Hisatomi H.
Expression of glutathione reductase splice variants in human tissues.
Biochem. Genet.
48
816-821
2010
678581
Nusbaum C.,Mikkelsen T.S.,Zody M.C.,Asakawa S.,Taudien S.,Garber M.,Kodira C.D.,Schueler M.G.,Shimizu A.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Allen N.R.,Anderson S.,Asakawa T.,Blechschmidt K.,Bloom T.,Borowsky M.L.,Butler J.,Cook A.,Corum B.,DeArellano K.,DeCaprio D.,Dooley K.T.,Dorris L. III,Engels R.,Gloeckner G.,Hafez N.,Hagopian D.S.,Hall J.L.,Ishikawa S.K.,Jaffe D.B.,Kamat A.,Kudoh J.,Lehmann R.,Lokitsang T.,Macdonald P.,Major J.E.,Matthews C.D.,Mauceli E.,Menzel U.,Mihalev A.H.,Minoshima S.,Murayama Y.,Naylor J.W.,Nicol R.,Nguyen C.,O'Leary S.B.,O'Neill K.,Parker S.C.J.,Polley A.,Raymond C.K.,Reichwald K.,Rodriguez J.,Sasaki T.,Schilhabel M.,Siddiqui R.,Smith C.L.,Sneddon T.P.,Talamas J.A.,Tenzin P.,Topham K.,Venkataraman V.,Wen G.,Yamazaki S.,Young S.K.,Zeng Q.,Zimmer A.R.,Rosenthal A.,Birren B.W.,Platzer M.,Shimizu N.,Lander E.S.
DNA sequence and analysis of human chromosome 8.
Nature
439
331-335
2006
678583
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
678584
Krauth-Siegel R.L.,Blatterspiel R.,Saleh M.,Schiltz E.,Schirmer R.H.,Untucht-Grau R.
Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain.
Eur. J. Biochem.
121
259-267
1982
678585
Krohne-Ehrich G.,Schirmer R.H.,Untucht-Grau R.
Glutathione reductase from human erythrocytes. Isolation of the enzyme and sequence analysis of the redox-active peptide.
Eur. J. Biochem.
80
65-71
1977
678586
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
678587
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
678588
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
678589
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
678590
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
678591
Kamerbeek N.M.,van Zwieten R.,de Boer M.,Morren G.,Vuil H.,Bannink N.,Lincke C.,Dolman K.M.,Becker K.,Schirmer R.H.,Gromer S.,Roos D.
Molecular basis of glutathione reductase deficiency in human blood cells.
Blood
109
3560-3566
2007
678592
Thieme R.,Pai E.F.,Schirmer R.H.,Schulz G.E.
Three-dimensional structure of glutathione reductase at 2-A resolution.
J. Mol. Biol.
152
763-782
1981
678593
Karplus P.A.,Schulz G.E.
Refined structure of glutathione reductase at 1.54-A resolution.
J. Mol. Biol.
195
701-729
1987
678594
Savvides S.N.,Karplus P.A.
Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor.
J. Biol. Chem.
271
8101-8107
1996
678595
Stoll V.S.,Simpson S.J.,Krauth-Siegel R.L.,Walsh C.T.,Pai E.F.
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry
36
6437-6447
1997
678596
Becker K.,Savvides S.N.,Keese M.,Schirmer R.H.,Karplus P.A.
Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.
Nat. Struct. Biol.
5
267-271
1998
