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glutathione disulfide reductase
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glutathione reductase (NADPH)
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glutathione reductase 3
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glutathione reductase Glr1
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glutathione S-reductase
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glutathione: NADP(+) oxidoreductase
glutathione: NADP+ oxidoreductase
glutathione:NADP+ oxidoreductase
multifunctional thioredoxin-glutathione reductase
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NADPH-glutathione reductase
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NADPH-GSSG reductase
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NADPH: oxidized glutathione oxidoreductase
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NADPH:oxidized glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
reductase, glutathione
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thioredoxin glutathione reductase
thioredoxin/glutathione reductase
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EC 1.6.4.2
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formerly
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GLR
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glutathione reductase
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glutathione reductase
Amphiprora kufferathii
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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657878, 658250, 659592, 659860, 671910, 673194, 673458, 674175, 674440, 677215, 686259, 688172, 690134, 690147, 696556, 696681, 699224, 699241, 711008, 712066
glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
Pibocella sp.
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
WP_010214957
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione reductase
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glutathione: NADP(+) oxidoreductase
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glutathione: NADP(+) oxidoreductase
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glutathione: NADP+ oxidoreductase
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glutathione: NADP+ oxidoreductase
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glutathione:NADP+ oxidoreductase
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glutathione:NADP+ oxidoreductase
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glutathione:NADP+ oxidoreductase
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GR
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GR1
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GR1
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cytosolic isoform, about 65% of the total glutathione reductase activity is attributed to isoform GR1
GR1
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chloroplastic isoform
GR2
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GR2
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isoform dual-targeted to chloroplasts and mitochondria, about 35% of the total glutathione reductase activity is attributed to isoform GR2
Gr3
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chloroplastic isoform
Gsr
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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NADPH:oxidized-glutathione oxidoreductase
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TGR
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thioredoxin glutathione reductase
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thioredoxin glutathione reductase
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chimeric enzyme able to transport reducing equivalents from NADPH to both GSH/GSSG and thioredoxin systems via the fusion of the thioredxin reductase and glutathione reductase domains
thioredoxin glutathione reductase
multifunctional enzyme involving a fusion of two proteins, glutaredoxin and thioredoxin reductase
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
ping-pong mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
ping-pong mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
ping-pong mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
member of pyridine-nucleotide disulfide oxidoreductase family of flavoenzymes
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
member of pyridine-nucleotide disulfide oxidoreductase family of flavoenzymes
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
member of pyridine-nucleotide disulfide oxidoreductase family of flavoenzymes
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
activity is dependent on a redox-active disulfide in each of the active centres
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
a dimeric flavoprotein (FAD)
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
sulfhydryl groups and histidine residues are essential for the catalytic properties of the enzyme
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
recombinant glutathione-trypanothione reductase-like enzyme, substrate binding, three dimensional structure, complex formation
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
inhibition mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
analogous to trypanothione reductase
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
analogous to trypanothione reductase
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
catalytic cycle
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
branching mechanism
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
GSSG-binding site
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
substrate and cofactor binding site, three-dimensional structure
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
substrate and cofactor binding site, three-dimensional structure
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
cofactor binding of glutathione reductase with FAD analogues, reconstitution
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
cofactor binding of glutathione reductase with FAD analogues, reconstitution
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
molecular modeling of enzyme inactivation by peroxynitrite, structure analysis
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
active site structure
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
active site structure, Cys39/Cys44 are involved
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
enzyme contains a catalytic selenocysteine
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
the multifunctional enzyme possesses both thioredoxin reductase activity, EC 1.8.1.9, glutathione reductase activity, EC 1.8.1.7, and glutaredoxin activity
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2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
the enzyme follows the Ping Pong mechanism
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(Z)-ajoene + NADPH + H+
4,5,9-trithiadodeca-1,6,11-triene + 4,8,9,13-tetrathiahexadeca-1,6,10,15-tetraene + NADP+
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r
1,4-dihydroxy-9,10-anthraquinone + NADPH
?
1,4-naphthoquinone + NADPH + H+
?
1,8-dihydroxy-9,10-anthraquinone + NADPH
?
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?
2 ajoene + 4 NADPH + 4 H+
4,8,9,13-tetrathiahexadeca-1,6,1,15-tetraene + 4 NADP+ + 2 allylmercaptan
2,3-dimethylquinoxaline-5,8-dione + NADPH + H+
?
2,5-bis(aziridin-1-yl)-3,6-dimethylcyclohexa-2,5-diene-1,4-dione + NADPH
?
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?
2,5-bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione + NADPH
?
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?
2,5-bis(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione + NADPH
?
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?
2,5-bis(ethylamino)-3,6-di(aziridinyl)-1,4-benzoquinone + NADPH
?
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?
2,6-dimethyl-1,4-benzoquinone + NADPH
?
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?
2-hydroxy-1,4-naphthoquinone + NADPH
?
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?
2-hydroxy-3-methyl-1,4-naphthoquinone + NADPH
?
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?
2-methyl-1,4-naphthoquinone + NADPH
?
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?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
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?
5,8-dihydroxy-1,4-naphthoquinone + NADPH
?
5-hydroxy-1,4-naphthoquinone + NADPH
?
6,7-dimethylquinoline-5,8-dione + NADPH + H+
?
6-methylquinoline-5,8-dione + NADPH + H+
?
7-methylquinoline-5,8-dione + NADPH + H+
?
9,10-phenanthrene quinone + NADPH
?
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?
ajoene + NADPH + H+
4,5,9-trithiadodeca-1,6,11-triene + NADP+ + H2O
AuCl4- + NADPH + H+
?
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formation of gold nanoparticles at the active site of glutathione reductase that are tightly bound through the catalytic cysteines. The nanoparticles can be removed from the glutathione reductase active site with thiol reagents such as 2-mercaptoethanol
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?
bis-N,N'-(gamma-glutamylcystine) + NADPH + H+
?
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r
bis-N-chloro-gamma-L-glutamyl derivative of GSSG + NADPH + H+
? + glutathione + NADP+
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?
diallyl trisulfide + NADPH
?
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?
diethyl [2,5-bis(aziridin-1-yl)-3,6-dioxocyclohexa-1,4-diene-1,4-diyl]biscarbamate + NADPH
?
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?
ferricyanide + NADPH + H+
ferrocyanide + NADP+
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r
glutathione + NADP+
glutathione disulfide + NADPH + H+
glutathione disulfide + NADH + H+
2 glutathione + NAD+
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?
glutathione disulfide + NADH + H+
glutathione + NAD+
glutathione disulfide + NADPH
glutathione + NADP+
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
glutathione disulfide + NADPH + H+
glutathione + NADP+
glutathione-S-sulfonate + NADPH + H+
?
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r
GSSG + NADPH
glutathione + NADP+
GSSG + NADPH + H+
glutathione + NADP+
GSSG + NADPH + H+
GSH + NADP+
peroxynitrite + NADPH
nitrite + H2O + NADP+
quinoline-5,8-dione + NADPH + H+
?
quinoxaline-5,8-dione + NADPH + H+
?
S-allylmercaptoglutathione disulfide + NADPH + H+
2 S-allylmercaptoglutathione + NADP+
S-nitrosoglutathione + NADPH + H+
? + NADP+
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?
tetramethyl-1,4-benzoquinone + NADPH
?
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?
trimethyl-1,4-benzoquinone + NADPH
?
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?
trimethyl-aziridinyl-1,4-benzoquinone + NADPH
?
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?
trypanothione + NADPH
reduced trypanothione + NADP+
additional information
?
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1,4-dihydroxy-9,10-anthraquinone + NADPH
?
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?
1,4-dihydroxy-9,10-anthraquinone + NADPH
?
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?
1,4-naphthoquinone + NADPH + H+
?
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?
1,4-naphthoquinone + NADPH + H+
?
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?
1,4-naphthoquinone + NADPH + H+
?
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?
2 ajoene + 4 NADPH + 4 H+
4,8,9,13-tetrathiahexadeca-1,6,1,15-tetraene + 4 NADP+ + 2 allylmercaptan
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i.e. (E,Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide, substrate and inhibitor
-
?
2 ajoene + 4 NADPH + 4 H+
4,8,9,13-tetrathiahexadeca-1,6,1,15-tetraene + 4 NADP+ + 2 allylmercaptan
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also formation of single-electron reduced product and concomitantly superoxide anion radicals
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?
2,3-dimethylquinoxaline-5,8-dione + NADPH + H+
?
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?
2,3-dimethylquinoxaline-5,8-dione + NADPH + H+
?
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?
5,8-dihydroxy-1,4-naphthoquinone + NADPH
?
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?
5,8-dihydroxy-1,4-naphthoquinone + NADPH
?
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?
5-hydroxy-1,4-naphthoquinone + NADPH
?
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?
5-hydroxy-1,4-naphthoquinone + NADPH
?
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?
6,7-dimethylquinoline-5,8-dione + NADPH + H+
?
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?
6,7-dimethylquinoline-5,8-dione + NADPH + H+
?
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?
6-methylquinoline-5,8-dione + NADPH + H+
?
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?
6-methylquinoline-5,8-dione + NADPH + H+
?
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?
7-methylquinoline-5,8-dione + NADPH + H+
?
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?
7-methylquinoline-5,8-dione + NADPH + H+
?
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?
ajoene + NADPH + H+
4,5,9-trithiadodeca-1,6,11-triene + NADP+ + H2O
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i.e. (E,Z)-4,5,9-trithiadodeca-1,6,11-triene-9-oxide, substrate and inhibitor
-
?
ajoene + NADPH + H+
4,5,9-trithiadodeca-1,6,11-triene + NADP+ + H2O
-
also formation of single-electron reduced product and concomitantly superoxide anion radicals
-
?
glutathione + NADP+
glutathione disulfide + NADPH + H+
-
mixed disulfide of CoA and glutathione
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r
glutathione + NADP+
glutathione disulfide + NADPH + H+
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mixed disulfide of CoA and glutathione
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r
glutathione disulfide + NADH + H+
glutathione + NAD+
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?
1.8.1.7 glutathione-disulfide reductase
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