Sequence of FUT2_HUMAN
EC Number:2.4.1.69
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R
Other sequences found for EC No. 2.4.1.69
General information:
Sequence
0 MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL
60 RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS
120 RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK
180 FLRGLQVNGS RPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV
240 VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG
300 GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
673496
Kelly R.J.,Rouquier S.,Giorgi D.,Lennon G.G.,Lowe J.B.
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.
J. Biol. Chem.
270
4640-4649
1995
673497
Koda Y.,Soejima M.,Wang B.,Kimura H.
Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).
Eur. J. Biochem.
246
750-755
1997
673499
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
673500
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
673501
Kudo T.,Iwasaki H.,Nishihara S.,Shinya N.,Ando T.,Narimatsu I.,Narimatsu H.
Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals.
J. Biol. Chem.
271
9830-9837
1996
673502
Koda Y.,Soejima M.,Liu Y.,Kimura H.
Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency.
Am. J. Hum. Genet.
59
343-350
1996
673503
Boren T.,Falk P.,Roth K.A.,Larson G.,Normark S.
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.
Science
262
1892-1895
1993
673504
Lindesmith L.,Moe C.,Marionneau S.,Ruvoen N.,Jiang X.,Lindblad L.,Stewart P.,LePendu J.,Baric R.
Human susceptibility and resistance to Norwalk virus infection.
Nat. Med.
9
548-553
2003
673505
Palumberi D.,Aldi S.,Ermini L.,Ziche M.,Finetti F.,Donnini S.,Rosati F.
RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation.
J. Cell. Biochem.
111
229-238
2010
673506
Wacklin P.,Maekivuokko H.,Alakulppi N.,Nikkilae J.,Tenkanen H.,Raebinae J.,Partanen J.,Aranko K.,Maettoe J.
Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine.
PLoS ONE
6
0-0
2011
673507
Rausch P.,Rehman A.,Kuenzel S.,Haesler R.,Ott S.J.,Schreiber S.,Rosenstiel P.,Franke A.,Baines J.F.
Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype.
Proc. Natl. Acad. Sci. U.S.A.
108
19030-19035
2011
673508
Wacklin P.,Tuimala J.,Nikkilae J.,Tims S.,Maekivuokko H.,Alakulppi N.,Laine P.,Rajilic-Stojanovic M.,Paulin L.,de Vos W.M.,Maettoe J.
Faecal microbiota composition in adults is associated with the FUT2 gene determining the secretor status.
PLoS ONE
9
0-0
2014
673509
Liu Y.,Koda Y.,Soejima M.,Pang H.,Schlaphoff T.,du Toit E.D.,Kimura H.
Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa.
Hum. Genet.
103
204-210
1998
673510
Hazra A.,Kraft P.,Selhub J.,Giovannucci E.L.,Thomas G.,Hoover R.N.,Chanock S.J.,Hunter D.J.
Common variants of FUT2 are associated with plasma vitamin B12 levels.
Nat. Genet.
40
1160-1162
2008
