Sequence of MDH_METJA
EC Number:1.1.1.375
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
Q60176
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
313
34609
Reaction
a (2S)-2-hydroxycarboxylate + NAD(P)+ = a 2-oxocarboxylate + NAD(P)H + H+
Other sequences found for EC No. 1.1.1.375
General information:
Sequence
0 MKVTIIGASG RVGSATALLL AKEPFMKDLV LIGREHSINK LEGLREDIYD ALAGTRSDAN
60 IYVESDENLR IIDESDVVII TSGVPRKEGM SRMDLAKTNA KIVGKYAKKI AEICDTKIFV
120 ITNPVDVMTY KALVDSKFER NQVFGLGTHL DSLRFKVAIA KFFGVHIDEV RTRIIGEHGD
180 SMVPLLSATS IGGIPIQKFE RFKELPIDEI IEDVKTKGEQ IIRLKGGSEF GPAAAILNVV
240 RCIVNNEKRL LTLSAYVDGE FDGIRDVCIG VPVKIGRDGI EEVVSIELDK DEIIAFRKSA
300 EIIKKYCEEV KNL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
57663
Bult C.J.,White O.,Olsen G.J.,Zhou L.,Fleischmann R.D.,Sutton G.G.,Blake J.A.,FitzGerald L.M.,Clayton R.A.,Gocayne J.D.,Kerlavage A.R.,Dougherty B.A.,Tomb J.-F.,Adams M.D.,Reich C.I.,Overbeek R.,Kirkness E.F.,Weinstock K.G.,Merrick J.M.,Glodek A.,Scott J.L.,Geoghagen N.S.M.,Weidman J.F.,Fuhrmann J.L.,Nguyen D.,Utterback T.R.,Kelley J.M.,Peterson J.D.,Sadow P.W.,Hanna M.C.,Cotton M.D.,Roberts K.M.,Hurst M.A.,Kaine B.P.,Borodovsky M.,Klenk H.-P.,Fraser C.M.,Smith H.O.,Woese C.R.,Venter J.C.
Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.
Science
273
1058-1073
1996
57664
Graupner M.,Xu H.,White R.H.
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
J. Bacteriol.
182
3688-3692
2000
57665
Madern D.
The putative L-lactate dehydrogenase from Methanococcus jannaschii is an NADPH-dependent L-malate dehydrogenase.
Mol. Microbiol.
37
1515-1520
2000
57666
Madern D.,Ebel C.,Dale H.A.,Lien T.,Steen I.H.,Birkeland N.-K.,Zaccai G.
Differences in the oligomeric states of the LDH-like L-MalDH from the hyperthermophilic archaea Methanococcus jannaschii and Archaeoglobus fulgidus.
Biochemistry
40
10310-10316
2001
57667
Kawakami R.,Sakuraba H.,Goda S.,Tsuge H.,Ohshima T.
Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.
Biochim. Biophys. Acta
1794
1496-1504
2009
57668
Lee B.I.,Chang C.,Cho S.-J.,Eom S.H.,Kim K.K.,Yu Y.G.,Suh S.W.
Crystal structure of the MJ0490 gene product of the hyperthermophilic archaebacterium Methanococcus jannaschii, a novel member of the lactate/malate family of dehydrogenases.
J. Mol. Biol.
307
1351-1362
2001
