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Information on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

for references in articles please use BRENDA:EC1.1.1.375

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IUBMB Comments

The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) . The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ . The same organism also possesses an NAD+-specific enzyme with similar activity, cf. >EC 1.1.1.337, L-2-hydroxycarboxylate dehydrogenase (NAD+).

The enzyme appears in viruses and cellular organisms

Synonyms
lactate/malate dehydrogenase, mj0490, ldh-like l-maldh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2S)-2-hydroxycarboxylate + NAD(P)+ = a 2-oxocarboxylate + NAD(P)H + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links