Sequence of KTHY_MYCTU
EC Number:2.7.4.9
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + dTMP = ADP + dTDP
Other sequences found for EC No. 2.7.4.9
General information:
Sequence
0 MLIAIEGVDG AGKRTLVEKL SGAFRAAGRS VATLAFPRYG QSVAADIAAE ALHGEHGDLA
60 SSVYAMATLF ALDRAGAVHT IQGLCRGYDV VILDRYVASN AAYSAARLHE NAAGKAAAWV
120 QRIEFARLGL PKPDWQVLLA VSAELAGERS RGRAQRDPGR ARDNYERDAE LQQRTGAVYA
180 ELAAQGWGGR WLVVGADVDP GRLAATLAPP DVPS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
52301
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
52302
Munier-Lehmann H.,Chaffotte A.,Pochet S.,Labesse G.
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.
Protein Sci.
10
1195-1205
2001
52303
Li de la Sierra I.,Munier-Lehmann H.,Gilles A.-M.,Barzu O.,Delarue M.
Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.
Acta Crystallogr. D
56
226-228
2000
52304
Raman K.,Yeturu K.,Chandra N.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
BMC Syst. Biol.
2
109-109
2008
52305
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
52306
Li de la Sierra I.,Munier-Lehmann H.,Gilles A.-M.,Barzu O.,Delarue M.
X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.
J. Mol. Biol.
311
87-100
2001
52307
Ursby T.,Weik M.,Fioravanti E.,Delarue M.,Goeldner M.,Bourgeois D.
Cryophotolysis of caged compounds: a technique for trapping intermediate states in protein crystals.
Acta Crystallogr. D
58
607-614
2002
52308
Haouz A.,Vanheusden V.,Munier-Lehmann H.,Froeyen M.,Herdewijn P.,Van Calenbergh S.,Delarue M.
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J. Biol. Chem.
278
4963-4971
2003
52309
Fioravanti E.,Haouz A.,Ursby T.,Munier-Lehmann H.,Delarue M.,Bourgeois D.
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.
J. Mol. Biol.
327
1077-1092
2003
52310
Fioravanti E.,Adam V.,Munier-Lehmann H.,Bourgeois D.
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.
Biochemistry
44
130-137
2005
