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(+/-)(Z)-5-acetamido-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
-
(+/-)(Z)-5-amino-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
-
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
(3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid
(4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one
i.e. [6]-shogaol, isolated from Zingiber officinale
(E)-5-(2-bromovinyl)-deoxyuridine
-
(NH4)2SO4
-
0.35 M, 50% inhibition
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
(S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
(S)-2-(3-fluorophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
(S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
(Z)-1-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[c,d]indol-2(1H)one
-
(Z)-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
-
(Z)-2-(4-(5-bromouracil-1-yl)but-2-enyl)-1H-benzo[d,e] isoquinoline-1,3(2H)-dione
-
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[d,e]isoquinoline-1,3(2H)-dione
-
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-2,3-dihydro-1H-benzo-[d,e]isoquinolin-1-one
-
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-2H-naphtho[1,8 cd]isothiazole-1,1-dioxide
-
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-6-nitrobenzo[c,d]indol-2(1H)one
-
(Z)-8-acetamido-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
-
(Z)-8-amino-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
-
1,3-bis[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea
-
1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea
-
-
1-((2R,4S,5R)-4-hydroxy-5-(2-(methylsulfonyl)ethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
-
-
1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione
i.e. shogaol with thymine head group
1-(1-benzylpiperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-(1-[[4-(dimethylamino)phenyl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-(3,4-dichlorophenyl)-3-[[(2R,3R,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-(3,4-dichlorophenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-(3-amino-3-deoxy-2-O,3-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine
-
IC99: 500 microg/ml
1-(3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine
-
IC99: 100 microg/ml
1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
1-(4-benzyloxyphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-(4-bromobenzyl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
comparison with inhibition of human enzyme
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-(4-chlorophenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
1-[(1'R,4'S)-4'-((S)-2-fluoro-1-hydroxyethyl)cyclopent-2'-enyl]-1H-thymine
-
-
1-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(2E)-4-(5,6-dimethoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
inhibitor identified by 3D-QSAR pharmacophore generation
1-[(2E)-4-[5,6-bis(hydroxymethyl)-2-oxobenzo[cd]indol-1(2H)-yl]but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
inhibitor identified by 3D-QSAR pharmacophore generation
1-[(2S,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[(2S,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[(2Z)-(4-(5-bromouracil-1-yl)but-2-enyl)]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolin-2,2-dioxide
-
-
1-[(2Z)-4-(1,1-dioxido-2H-naphtho[1,8-cd][1,2]thiazol-2-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(4aR,5S,7R,7aS)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[(Z)-(4-(thymin-1-yl)but-2-enyl)]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolin-2,2-dioxide
-
-
1-[1-(cyclohexylmethyl)piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(1-benzofuran-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(7-chloro-4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(furan-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(furan-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(isoquinolin-1-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(isoquinolin-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[1-[(isoquinolin-4-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[2,5-dideoxy-5-[([4-[(2-fluorophenyl)methoxy]phenyl]carbamoyl)amino]-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[2,5-dideoxy-5-[([4-[(2-methoxyphenyl)methoxy]phenyl]carbamoyl)amino]-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]-N-[1-(4-hydroxyphenyl)-3-oxoniopropan-2-yl]prolinamide
-
1-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]-3-phenylthiourea
-
1-[3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl]thymine
-
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[2-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]ethyl]thiourea
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]urea
-
1-[5-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2,5-dideoxy-a-D-erythro-pentofuranosyl]-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
-
-
1-[5-[([4-[(2-chlorophenyl)methoxy]phenyl]carbamoyl)amino]-2,5-dideoxy-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]pyrrolidine-2-carboxylate
-
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methoxyphenyl)thiourea
-
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-(4-methylphenyl)thiourea
-
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-phenylthiourea
-
1-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]-3-pyridin-3-ylthiourea
-
1-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]-3-phenylthiourea
-
2',3'-dideoxy-2',3'-didehydrothymidine
poor inhibitor
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine
-
-
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine
-
-
2',5'-difluoro-3'-azidomethylthymidine
-
2'-chlorothymidine 5'-monophosphate
-
2'-deoxy-5-(hydroxymethyl)uridine
-
-
2'-deoxy-5-(trifluoromethyl)uridine
-
-
2'-deoxy-5-ethyluridine
-
-
2'-deoxy-5-fluorouridine
-
-
2'-deoxy-5-hydroxyuridine
-
-
2'-fluorothymidine 5'-monophosphate
-
2-((2R,3S,5R)-3-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-N-methylethanesulfonamide
-
-
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid
-
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid
-
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
-
2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
-
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2-(3-chlorophenoxy)-3-methoxy-4-[(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl]benzoic acid
-
2 g/ml MIC against methicillin-resistant Staphylococcus aureus. The compound exhibits a striking inverted chiral preference for binding relative to earlier compounds and also has improved physical properties and pharmacokinetics
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)-3-(1H-indol-3-yl)propanoate
-
2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)-3-(4-methylphenyl)propanoate
-
2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)-3-hydroxypropanoate
-
2-([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]prolyl]amino)pentanedioate
-
2-([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]prolyl]amino)-3-(1H-indol-3-yl)propanoate
-
2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-3-(4-hydroxyphenyl)propanoate
-
2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-3-hydroxybutanoate
-
2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-3-hydroxypropanoate
-
2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)-4-carboxybutanoate
-
2-([N-[2-ammonio-3-(1H-indol-3-yl)propanoyl]tyrosyl]amino)butanedioate
-
2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid
-
2-mercaptoethanol
-
0.4 mM
2-[(4aS,5R,7R,7aR)-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-2,2-dioxidooctahydrocyclopenta[c][1,2,6]thiadiazin-7-yl]-N-methylethanesulfonamide
-
-
2-[([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]methyl)amino]butanedioate
-
2-[([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]acetyl)amino]-3-hydroxybutanoate
-
2-[([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]acetyl)amino]-3-hydroxypropanoate
-
2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid
-
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine
-
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine
-
-
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine
-
-
3'-(aminomethyl)-2'-chloro-3'-deoxythymidine
-
3'-(aminomethyl)-3'-deoxythymidine
3'-(azidomethyl)-2'-chloro-3'-deoxythymidine
-
3'-(azidomethyl)-3'-deoxy-2'-fluorothymidine
-
3'-(azidomethyl)-3'-deoxy-alpha-D-ribosyl-thymine
3'-(azidomethyl)-3'-deoxythymidine
3'-([[(4-chlorophenyl)carbamothioyl]amino]methyl)-3'-deoxythymidine
-
3'-azido-2',3'-dideoxyuridine
-
-
3'-azido-3'-deoxy-4-thio-beta-D-thymidine
-
-
3'-azido-3'-deoxy-alpha-D-thymidine
-
-
3'-azido-3'-deoxy-thymidine-5'-monophosphate
-
3'-azido-3'-deoxythymidine
3'-azido-3'-deoxythymidine 5'-monophosphate
3'-azido-3'-deoxythymidine 5'-phosphate
-
3'-azido-3'-deoxythymidine monophosphate
-
-
3'-azido-5-bromo-2',3'-dideoxyuridine
-
-
3'-azido-5-chloro-2',3'-dideoxyuridine
-
-
3'-azidothymidine
poor inhibitor
3'-deoxy-3'-([[(3,4-dichlorophenyl)carbamothioyl]amino]methyl)thymidine
-
3'-deoxy-3'-([[(4-methoxyphenyl)carbamothioyl]amino]methyl)thymidine
-
3'-deoxy-3'-([[(4-methylphenyl)carbamothioyl]amino]methyl)thymidine
-
3'-deoxythymidine 5'-monophosphate
-
3'-[([[4-(benzyloxy)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
-
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine
-
-
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-3'-deoxythymidine
-
3-((2R,3S,5R)-3-hydroxy-5-(5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile
-
-
3-((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile
-
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide
-
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide
-
3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
-
3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
-
3-([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]prolyl]amino)-4-oxoniobutanoate
-
4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
-
4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
-
4-([1-[2-ammonio-3-(4-hydroxyphenyl)propanoyl]prolyl]amino)-5-oxoniopentanoate
-
4-[3-cyano-2-oxo-7-(1H-pyrazol-4-yl)-5,6-dihydro-1H-benzo[h]quinolin-4-yl]benzoic acid
compound shows showed cellular activity against Mycobacterium tuberculosis
4-[3-cyano-6-(3-methoxyphenyl)-2-oxo-1H-pyridin-4-yl]benzoic acid
compound shows showed cellular activity against Mycobacterium tuberculosis, MIC value above 32 microg/ml
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
comparison with inhibition of human enzyme
4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzoic acid
-
4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzonitrile
-
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine
-
-
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine
-
-
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine
-
-
5'-([[4-chloro-3-(trifluoromethyl)benzyl]carbamothioyl]amino)-5'-deoxythymidine
-
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine
-
-
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine
-
-
5'-amino-5'-deoxythymidine
-
-
5'-aminodeoxythymidine
-
-
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine
-
-
5'-azido-5'-deoxythymidine
-
-
5'-carboxyldeoxythymidine
-
-
5'-chlorodeoxythymidine
-
-
5'-deoxy-5'-(methylamino)thymidine
-
-
5'-deoxy-5'-([[2-(3,4-dichlorophenyl)ethyl]carbamothioyl]amino)thymidine
-
5'-deoxy-5'-[(tricyclo[3.3.1.13,7]dec-1-ylcarbamothioyl)amino]thymidine
-
5'-deoxy-5'-[2-(methylsulfonyl)benzenesulfonylamido]thymidine
-
91% inhibition
5'-deoxy-5'-[4-(4-fluorophenyl)-(1,2,3)triazol-1-yl]thymidine
-
87% inhibition of enzyme activity, inhibition of Bacillus anthracis Sterne growth
5'-deoxy-5'-[4-(methylsulfonyl)benzenesulfonylamido]thymidine
-
94% inhibition
5'-deoxy-5'-[[(2-phenylethyl)carbamothioyl]amino]thymidine
-
5'-deoxy-5'-[[(3,4-dichlorophenyl)carbamoyl]amino]thymidine
-
5'-deoxy-5'-[[(4-morpholin-4-ylphenyl)carbamothioyl]amino]thymidine
-
5'-deoxy-5'-[[(diphenylmethyl)carbamothioyl]amino]thymidine
-
5'-deoxy-5'-[[(phenylcarbonyl)carbamothioyl]amino]thymidine
-
5'-deoxy-5'-[[2-(methylthio)anilinothiocarbonyl]amino]thymidine
-
84% inhibition
5'-deoxy-5'-[[3-(methylthio)anilinothiocarbonyl]amino]thymidine
-
69% inhibition of enzyme activity, inhibition of Bacillus anthracis Sterne growth
5'-iododeoxythymidine
-
-
5'-[(benzylcarbamothioyl)amino]-5'-deoxythymidine
-
5'-[([[9-(2-carboxyphenyl)-3-oxo-2,3-dihydro-1H-xanthen-6-yl]oxy]carbamothioyl)amino]-5'-deoxythymidine
-
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
-
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
-
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
-
5,5'-dithio-bis(2-nitrobenzoic acid)
-
general thymidylate kinase inhibitor
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
-
-
5-bromo-1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-pyrimidine-2,4-(1H,3H)-dione
i.e. shogaol with bromouracil head group
5-fluorodeoxyuridine
poor inhibitor
5-iodo-5'-fluoro-2',5'-dideoxyuridine
-
-
5-methoxy-2-[(2E)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-1H-isoindole-1,3(2H)-dione
inhibitor identified by 3D-QSAR pharmacophore generation
5-methyl iso-dCMP
-
competitive
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
5-methyl-1-(1-[[4-(1H-tetrazol-5-yl)phenyl]methyl]piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-(2-[methyl[(3-phenoxyphenyl)methyl]amino]ethyl)pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[(2Z)-4-(2-oxobenzo[cd]indol-1(2H)-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-methyl-1-[(3S)-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-(2-phenylethyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-(3-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
5-methyl-1-[1-(4-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(3-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(3-phenoxyphenyl)methyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(3-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(4-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(4-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(naphthalen-1-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(naphthalen-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(pyridin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(pyridin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(quinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(quinolin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[(quinolin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[3-(3-phenoxyphenyl)propyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
5-[(E)-2-bromoethenyl]-2'-deoxyuridine
-
-
5-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
-
comparison with inhibition of human enzyme
5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
5-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]pyridine-2-carboxylic acid
-
6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one
-
6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
-
6-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide
-
comparison with inhibition of human enzyme
6-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide
-
comparison with inhibition of human enzyme
6-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide
-
comparison with inhibition of human enzyme
CH2ATP
-
100 nM, 23% inhibition
D-2'-fluoroarabinosyl-5-methyldeoxyuridine
poor inhibitor; strong
dAMP
-
5 mM, about 15% inhibition
dGDP
-
0.5 mM, 23% inhibition
dGTP
-
100 nM, 12% inhibition
EDTA
-
4 mM, 80% loss of activity
GDP
-
100 nM, 21% inhibition
guanidine hydrochloride
guanidine hydrochloride-induced unfolding of thymidylate kinase is noncooperative and influences the functional properties of the enzyme much less than their Cm values. Complete inhibition at 0.4 M
KCl
-
0.5 M, 10% inhibition
methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate
-
N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
-
N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
-
N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
-
N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea
N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide
-
N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
-
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea
-
-
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea
N-(5'-deoxy-alpha-thymidin-5'-yl)-N'-[4-(2-chlorobenzyloxy)phenyl]urea
-
N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
-
N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
-
N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
-
N-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]benzamide
-
NaCl
-
0.1 M, 25% inhibition
NH4Cl
-
0.4 M, 75% inhibition
P1,P5-di(adenosine-5')pentaphosphate
potential inhibitor
P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate
-
P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate
-
-
P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate
-
-
P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate
-
-
UMP
-
5 mM, about 15% inhibition
Urea
urea-induced unfolding of thymidylate kinase is noncooperative and influences the functional properties of the enzyme much less than their Cm values. Complete inhibition at 1.0 M
[(1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl]methyl acetate
-
-
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
-
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
-
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
-
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
-
(3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
(3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid
-
comparison with inhibition of human enzyme
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
(S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
-
(S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
-
(S)-2-(3-fluorophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
-
(S)-2-(3-fluorophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
-
(S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
-
-
(S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
-
-
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
-
-
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
-
-
1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea
-
-
1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea
-
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
comparison with inhibition of human enzyme
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
-
3'-(aminomethyl)-3'-deoxythymidine
-
-
3'-(aminomethyl)-3'-deoxythymidine
-
3'-(azidomethyl)-3'-deoxy-alpha-D-ribosyl-thymine
-
-
3'-(azidomethyl)-3'-deoxy-alpha-D-ribosyl-thymine
-
3'-(azidomethyl)-3'-deoxythymidine
-
-
3'-(azidomethyl)-3'-deoxythymidine
-
3'-azido-3'-deoxythymidine
-
3'-azido-3'-deoxythymidine
-
-
3'-azido-3'-deoxythymidine
specific inhibitory effect on the enzyme activity, and these effect is in good association with binding interactions and the scoring functions
3'-azido-3'-deoxythymidine 5'-monophosphate
-
potent competitive inhibitor
3'-azido-3'-deoxythymidine 5'-monophosphate
-
3'-azido-3'-deoxythymidine 5'-monophosphate
potential inhibitor
3'-azido-3'-deoxythymidine 5'-monophosphate
potential inhibitor of the bacterial enzyme, not inhibitory in human
4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
-
-
4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
-
-
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
-
not inhibitory up to 2 mM, inhibitory to Mycobacterium tuberculosis enzyme
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
-
comparison with inhibition of human enzyme
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
comparison with inhibition of human enzyme
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
-
not inhibitory up to 2 mM, inhibitory to Mycobacterium tuberculosis enzyme
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
-
comparison with inhibition of human enzyme
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
comparison with inhibition of human enzyme
5-bromo-2'-deoxyuridine
-
-
5-bromo-2'-deoxyuridine
-
potential inhibitor with high selectivity between bacterial and human enzyme
5-bromo-2'-deoxyuridine
-
-
5-bromo-2'-deoxyuridine
specific inhibitory effect on the enzyme activity, and these effect is in good association with binding interactions and the scoring functions
5-chloro-2'-deoxyuridine
-
-
5-chloro-2'-deoxyuridine
-
potential inhibitor with high selectivity between bacterial and human enzyme
5-chloro-2'-deoxyuridine
-
-
5-chloro-2'-deoxyuridine
specific inhibitory effect on the enzyme activity, and these effect is in good association with binding interactions and the scoring functions
5-fluoro-2'-deoxyuridine
-
not inhibitory at 4 mM
5-fluoro-2'-deoxyuridine
-
potential inhibitor with high selectivity between bacterial and human enzyme
5-iodo-2'-deoxyuridine
-
-
5-iodo-2'-deoxyuridine
-
potential inhibitor with high selectivity between bacterial and human enzyme
5-iodo-2'-deoxyuridine
-
-
5-iodo-dUMP
-
competitive versus both thymidylate and thymidine
5-iodo-dUMP
-
2.5 mM, 30% inhibition
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
-
-
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
-
-
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
-
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
-
-
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
-
-
5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
-
comparison with inhibition of human enzyme
ADP
-
25% inhibition
ADP
-
0.5 mM, 33% inhibition
ADP
-
ADP*Mg2+ product inhibition, competitive versus MgATP2-, noncompetitive versus thymidylate
ADP
-
100 nM, 64% inhibition
ADP
-
2.5 mM, 24% inhibition
dADP
-
0.5 mM, 34% inhibition
dADP
-
100 nM, 57% inhibition
dADP
-
2.5 mM, 23% inhibition
dATP
-
0.4 mM, 12% inhibition, adult liver
dATP
-
100 nM, 15% inhibition
deoxythymidine
poor inhibitor
deoxythymidine
-
potential inhibitor with high selectivity between bacterial and human enzyme
dTDP
-
0.4 mM, 48% inhibition
dTDP
-
0.5 mM, 91% inhibition
dTDP
-
product inhibition, competitive versus MgATP2-
dTDP
-
100 nM, 39% inhibition
dTDP
-
2.5 mM, 75% inhibition
dTDP
competitive with dTMP
dTMP
-
-
dTTP
-
-
dTTP
-
0.4 mM, 43% inhibition
dTTP
-
competitive versus both thymidine and thymidylate
dTTP
-
potent feedback inhibitor of dTMP
dTTP
-
2.5 mM, 17% inhibition
dUDP
-
0.5 mM, 42% inhibition
dUDP
-
2.5 mM, 15% inhibition
dUMP
-
-
dUMP
-
5 mM, about 15% inhibition
dUMP
-
2.5 mM, 19% inhibition
N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea
comparison with inhibition of human enzyme
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea
comparison with inhibition of human enzyme
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea
comparison with inhibition of human enzyme
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea
-
comparison with inhibition of Mycobacterium tuberculosis enzyme
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea
comparison with inhibition of human enzyme
thymidine
-
0.77 mM, 27% inhibition
thymidine
-
2.5 mM, 40% inhibition
TK-666
-
i.e. 2-(3-bromophenoxy)-4-((R)-3,3-dimethyl-1-((S)-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
TK-666
-
i.e. 2-(3-bromophenoxy)-4-((R)-3,3-dimethyl-1-((S)-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
additional information
-
3-azido-3-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents
-
additional information
-
acyclic nucleoside analogues (Z)-2-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[d,e]isoquinoline-1,3(2H)-dione and (Z)-2-(4-(thymin-1-yl)but-2-enyl)-2,3-dihydro-1H-benzo-[d,e]isoquinolin-1-one are not inhibitory up to 0.02 mM
-
additional information
several different TMP analogues tested and found to be inhibitory
-
additional information
-
several different TMP analogues tested and found to be inhibitory
-
additional information
3'-(aminomethyl)-3'-deoxy-2'-fluorothymidine is not inhibitory at 1 mM; 3-azido-3-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents
-
additional information
-
3'-(aminomethyl)-3'-deoxy-2'-fluorothymidine is not inhibitory at 1 mM; 3-azido-3-deoxythymidine monophosphate is not inhibitory, various thymine derivatives tested and found to inhibit activity to different extents
-
additional information
-
not inhibited by N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-phenylthiourea
-
additional information
-
not inhibited by 3-((2R,3S,5R)-3-hydroxy-5-(5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile and 1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
-
additional information
-
not inhibitory: 2-mercaptoethanol up to 5 mM, AMP, CMP, dCMP, GMP and dGMP and
-
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0.0058
(+/-)(Z)-5-acetamido-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.00707
(+/-)(Z)-5-amino-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.039 - 0.252
(3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid
0.0108
(4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one
pH 7.4, temperature not specified in the publication
0.5
(E)-5-(2-bromovinyl)-deoxyuridine
-
0.00042
(Z)-1-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[c,d]indol-2(1H)one
pH 7.4
0.00116
(Z)-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.0011
(Z)-2-(4-(5-bromouracil-1-yl)but-2-enyl)-1H-benzo[d,e] isoquinoline-1,3(2H)-dione
pH 7.4
0.0019
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-1H-benzo[d,e]isoquinoline-1,3(2H)-dione
pH 7.4
0.0014
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-2,3-dihydro-1H-benzo-[d,e]isoquinolin-1-one
pH 7.4
0.00027
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-2H-naphtho[1,8 cd]isothiazole-1,1-dioxide
pH 7.4
0.00075
(Z)-2-(4-(thymin-1-yl)but-2-enyl)-6-nitrobenzo[c,d]indol-2(1H)one
pH 7.4
0.00093
(Z)-8-acetamido-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.00246
(Z)-8-amino-1-(4-(thymin-1-yl)but-2-enyl)-5,6-dihydro-1H-imidazo[4,5,1-ij]quinolin-2(4H)-one
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.029
1,3-bis[[(2S,3R,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]urea
-
0.037
1-(((2R,3S,5S)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)-3-(((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)methyl)urea
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.34
1-((2R,4S,5R)-4-hydroxy-5-(2-(methylsulfonyl)ethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
pH and temperature not specified in the publication
0.07
1-((2R,4S,5R)-5-(2-(1H-tetrazol-5-yl)ethyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
pH and temperature not specified in the publication
0.0066
1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione
pH 7.4, temperature not specified in the publication
0.001 - 0.274
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.0072
1-(3,4-dichlorophenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
pH 7.4
0.008
1-(3-amino-3-deoxy-2-O,3-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine
-
-
0.0023
1-(3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine
-
-
0.005 - 1
1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
0.012
1-(4-benzyloxyphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
pH 7.4
0.038
1-(4-bromobenzyl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
0.0032 - 1
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.021
1-(4-chlorophenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
pH 7.4
0.014 - 0.02
1-[(1'R,4'S)-4'-((S)-2-fluoro-1-hydroxyethyl)cyclopent-2'-enyl]-1H-thymine
0.067 - 2.5
1-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.055 - 0.208
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1.54
1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.103 - 0.355
1-[(1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.007 - 0.02
1-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.089 - 0.246
1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.000004
1-[(2E)-4-(5,6-dimethoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
predicted value, pH not specified in the publication, temperature not specified in the publication
0.000004
1-[(2E)-4-[5,6-bis(hydroxymethyl)-2-oxobenzo[cd]indol-1(2H)-yl]but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
predicted value, pH not specified in the publication, temperature not specified in the publication
0.0003
1-[(2Z)-(4-(5-bromouracil-1-yl)but-2-enyl)]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolin-2,2-dioxide
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.00027
1-[(2Z)-4-(1,1-dioxido-2H-naphtho[1,8-cd][1,2]thiazol-2-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.0135 - 1.1
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.0035 - 0.7
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.00057
1-[(Z)-(4-(thymin-1-yl)but-2-enyl)]-5,6-dihydro-1H,4H-1,2,5-thiadiazolo[4,3,2-ij]quinolin-2,2-dioxide
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.0205
1-[2,5-dideoxy-5-[([4-[(2-fluorophenyl)methoxy]phenyl]carbamoyl)amino]-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
pH and temperature not specified in the publication
0.22
1-[2,5-dideoxy-5-[([4-[(2-methoxyphenyl)methoxy]phenyl]carbamoyl)amino]-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
pH and temperature not specified in the publication
0.0023
1-[3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl]thymine
-
-
0.0006 - 0.362
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
0.00017
1-[5-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2,5-dideoxy-a-D-erythro-pentofuranosyl]-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
-
pH and temperature not specified in the publication
0.225
1-[5-[([4-[(2-chlorophenyl)methoxy]phenyl]carbamoyl)amino]-2,5-dideoxy-alpha-D-erythro-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione
pH and temperature not specified in the publication
0.0042
2',5'-dideoxy-5'-(4-phenyl-1H-1,2,3-triazol-1-yl)-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0028
2',5'-dideoxy-5'-([[3-(trifluoromethyl)phenyl]carbamoyl]amino)-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.08
2',5'-difluoro-3'-azidomethylthymidine
-
0.019
2'-chlorothymidine 5'-monophosphate
-
0.82
2'-deoxy-5-(hydroxymethyl)uridine
-
-
1.14
2'-deoxy-5-ethyluridine
-
-
0.212
2'-deoxy-5-fluorouridine
-
-
0.27
2'-deoxy-5-hydroxyuridine
-
-
0.043
2'-fluorothymidine 5'-monophosphate
-
0.24
2-((2R,3S,5R)-3-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-N-methylethanesulfonamide
-
pH and temperature not specified in the publication
0.00029
2-[(4aS,5R,7R,7aR)-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-2,2-dioxidooctahydrocyclopenta[c][1,2,6]thiadiazin-7-yl]-N-methylethanesulfonamide
-
pH and temperature not specified in the publication
0.00043
2-[([1-[2-ammonio-3-(1H-indol-3-yl)propanoyl]pyrrolidin-2-yl]methyl)amino]butanedioate
pH and temperature not specified in the publication
0.028
3',5'-diazido-2',3',5'-trideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.015
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-4-thio-beta-D-thymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.035
3'-(4-chlorophenyl-1,2,3-triazol-1-yl)-3'-deoxy-alpha-D-thymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.39
3'-(aminomethyl)-2'-chloro-3'-deoxythymidine
-
0.057 - 0.22
3'-(aminomethyl)-3'-deoxythymidine
0.18
3'-(azidomethyl)-2'-chloro-3'-deoxythymidine
-
0.165
3'-(azidomethyl)-3'-deoxy-2'-fluorothymidine
-
0.04 - 1.04
3'-(azidomethyl)-3'-deoxythymidine
0.81
3'-azido-2',3'-dideoxyuridine
-
-
0.1
3'-azido-3'-deoxy-4-thio-beta-D-thymidine
-
Ki above 0.1 mM, in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.006
3'-azido-3'-deoxy-alpha-D-thymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.024 - 0.028
3'-azido-3'-deoxythymidine
0.05
3'-azido-3'-deoxythymidine 5'-monophosphate
pH 7.5
0.01
3'-azido-3'-deoxythymidine 5'-phosphate
pH 7.4
0.02
3'-azido-3'-deoxythymidine monophosphate
-
pH 7.4, 30°C
0.0105
3'-azido-5-bromo-2',3'-dideoxyuridine
-
-
0.016
3'-azido-5-chloro-2',3'-dideoxyuridine
-
-
0.027
3'-Deoxythymidine
pH and temperature not specified in the publication
0.005
3'-[([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)methyl]-2',3'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.048
3-((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)propanenitrile
-
pH and temperature not specified in the publication
0.039
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
-
-
0.01 - 0.293
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
0.039
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanamide
-
-
0.0065 - 0.79
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
0.013
4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
-
0.0027
5'-(4-benzyl-1H-1,2,3-triazol-1-yl)-2',5'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.009
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-alpha-D-thymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.201
5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-beta-D-thymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0006
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamothioyl]amino)-2',5'-dideoxy-3,4-dihydro-alpha-thymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0099
5'-([[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino)-2',5'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.012
5'-amino-5'-deoxythymidine
-
-
0.13
5'-aminodeoxythymidine
-
pH 7.5, 37°C
0.0265
5'-azido-2',5'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0073
5'-azido-5'-deoxythymidine
-
-
0.03
5'-carboxyldeoxythymidine
-
pH 7.5, 37°C
0.02
5'-chlorodeoxythymidine
-
pH 7.5, 37°C
0.013
5'-deoxy-5'-(methylamino)thymidine
-
-
0.004
5'-Deoxythymidine
-
-
0.071
5'-O-methylthymidine
-
-
0.0021
5'-[4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0023
5'-[5-(2-aminobenzyl)-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.045
5'-[5-amino-4-[4-chloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl]-2',5'-dideoxy-3,4-dihydrothymidine
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.073
5-(5'-amino-5'-deoxy-beta-D-thymidin-5'-N-yl)-1-(4-chloro-3-trifluoromethylphenyl)-tetrazole
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0083
5-bromo-1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-pyrimidine-2,4-(1H,3H)-dione
pH 7.4, temperature not specified in the publication
0.005 - 0.214
5-bromo-2'-deoxyuridine
0.007
5-bromo-deoxyuridine
-
0.01 - 0.375
5-chloro-2'-deoxyuridine
0.015
5-chloro-deoxyuridine
-
0.212
5-fluoro-2'-deoxyuridine
-
pH 7.4, 30°C
0.7
5-fluoro-deoxyuridine
-
0.11
5-hydroxymethyl-dUMP
-
pH and temperature not specified in the publication
0.033 - 0.35
5-iodo-2'-deoxyuridine
0.4
5-iodo-2'-dUMP
-
pH 7.8, 37°C
0.0006 - 0.0009
5-iodo-5'-fluoro-2',5'-dideoxyuridine
0.023
5-iodo-deoxyuridine
-
0.000004
5-methoxy-2-[(2E)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-1H-isoindole-1,3(2H)-dione
predicted value, pH not specified in the publication, temperature not specified in the publication
0.13
5-methyl iso-dCMP
-
pH 7.4, 30°C
0.00042
5-methyl-1-[(2Z)-4-(2-oxobenzo[cd]indol-1(2H)-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione
-
in 50 mM Tris-HCl pH 7.4, 50 mM KCl, 2 mM MgCl2, temperature not specified in the publication
0.625
5-[(E)-2-bromoethenyl]-2'-deoxyuridine
-
-
0.038
5-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
-
-
0.016 - 0.122
5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
0.0195
6-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide
-
-
0.026
6-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide
-
-
0.0265
6-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]hexanamide
-
-
0.21
ATP
pH 7.4, temperature not specified in the publication
0.025 - 0.18
deoxythymidine
0.117
dGMP
-
pH 7.4, 30°C
0.0011 - 0.0116
N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea
0.00017
N-(5'-deoxy-4-thio-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea
-
in 50 mM Tris-HCl, pH 7.4, 50 mM KCl, 2 mM MgCl2, at 37°C
0.0022 - 0.079
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea
0.0026 - 0.05
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea
0.0019 - 0.166
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea
0.03
P1,P5-di(adenosine-5')pentaphosphate
pH 7.5
0.0175 - 0.0209
P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate
0.00047 - 0.0006
P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate
0.00018 - 0.0002
P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate
0.036 - 0.206
[(1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl]methyl acetate
0.039
(3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid
-
-
0.252
(3E)-4-[4-[(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]but-3-enoic acid
-
-
0.001
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
pH 7.4
0.274
1-(3,4-dichlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
pH 7.4
0.005
1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
pH 7.4
1
1-(3-chloro-4-trifluoromethylphenyl)-3-[[(2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl]methyl]thiourea
-
pH 7.4
0.0032
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
pH 7.4
1
1-(4-chlorophenyl)-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
pH 7.4
0.014
1-[(1'R,4'S)-4'-((S)-2-fluoro-1-hydroxyethyl)cyclopent-2'-enyl]-1H-thymine
-
substrate TMP, pH 7.2, 30°C
0.02
1-[(1'R,4'S)-4'-((S)-2-fluoro-1-hydroxyethyl)cyclopent-2'-enyl]-1H-thymine
-
substrate dGMP, pH 7.2, 30°C
0.067
1-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
2.5
1-[(1R,2R,3S,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with TMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.055
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.208
1-[(1R,2R,4R,5S)-4-(hydroxymethyl)-6-oxabicyclo[3.1.0]hex-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with TMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.103
1-[(1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.355
1-[(1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with TMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.007
1-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.02
1-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with TMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.089
1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.246
1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
with TMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.0135
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
1.1
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-oxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
0.0035
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
0.0035
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
pH and temperature not specified in the publication
0.7
1-[(4aR,5S,7R,7aR)-5-(hydroxymethyl)-2-thioxohexahydro-2H-furo[3,4-e][1,3]oxazin-7-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
-
-
0.0006
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
pH 7.4
0.362
1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl]thiourea
-
pH 7.4
0.057
3'-(aminomethyl)-3'-deoxythymidine
-
0.22
3'-(aminomethyl)-3'-deoxythymidine
-
-
0.04
3'-(azidomethyl)-3'-deoxythymidine
-
1.04
3'-(azidomethyl)-3'-deoxythymidine
-
-
0.024
3'-azido-3'-deoxythymidine
pH 7.4, temperature not specified in the publication
0.028
3'-azido-3'-deoxythymidine
-
-
0.01
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
-
0.293
4-[4-[(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
-
0.0065
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
-
0.79
4-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]butanoic acid
-
-
0.005
5-bromo-2'-deoxyuridine
-
-
0.005
5-bromo-2'-deoxyuridine
-
pH 7.4, 30°C
0.042
5-bromo-2'-deoxyuridine
pH 7.4, temperature not specified in the publication
0.214
5-bromo-2'-deoxyuridine
-
pH 7.4, 30°C
0.01
5-chloro-2'-deoxyuridine
-
-
0.01
5-chloro-2'-deoxyuridine
-
pH 7.4, 30°C
0.02
5-chloro-2'-deoxyuridine
pH 7.4, temperature not specified in the publication
0.375
5-chloro-2'-deoxyuridine
-
pH 7.4, 30°C
0.033
5-iodo-2'-deoxyuridine
-
-
0.033
5-iodo-2'-deoxyuridine
-
pH 7.4, 30°C
0.35
5-iodo-2'-deoxyuridine
-
pH 7.4, 30°C
0.0006
5-iodo-5'-fluoro-2',5'-dideoxyuridine
-
versus thymidylate
0.0009
5-iodo-5'-fluoro-2',5'-dideoxyuridine
-
versus thymidine
0.016
5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
-
-
0.122
5-[4-[(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]phenyl]pentanoic acid
-
-
0.047
ADP
-
pH 8.5, 25°C, with ATP as variable substrate
0.415
ADP
-
pH 8.5, 25°C, with dTMP as variable substrate
0.025
deoxythymidine
-
0.027
deoxythymidine
-
pH 7.4, 30°C
0.18
deoxythymidine
-
pH 7.4, 30°C
0.03
dTDP
-
pH 7.5, 37°C
0.059
dTDP
-
versus thymidylate
0.23
dTDP
pH 7.4, temperature not specified in the publication
0.0045
dTMP
-
0.16
dTMP
-
pH 8.5, 25°C, dTMP as variable substrate
0.027
dTTP
-
pH 7.5, 37°C
0.05
dTTP
-
verus thymidylate
0.062
dTTP
-
versus thymidine
0.06
MgADP-
-
versus ATP*Mg2+
0.1
MgADP-
-
versus thymidylate
0.0011
N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea
pH 7.4
0.0116
N-(3,4-dichlorophenyl)-N'-(5'-deoxy-alpha-D-thymidin-5'-yl)-urea
-
pH 7.4
0.0022
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea
pH 7.4
0.079
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3,4-dichlorophenylethyl)thiourea
-
pH 7.4
0.0026
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea
pH 7.4
0.05
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorobenzyl)thiourea
-
pH 7.4
0.0019
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea
pH 7.4
0.166
N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(4-chloro-3-(trifluoromethyl)phenylethyl)urea
-
pH 7.4
0.0175
P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate
-
pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate
0.0209
P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate
-
pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate
0.00047
P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate
-
pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate
0.0006
P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate
-
pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate
0.00018
P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate
-
pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate
0.0002
P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate
-
pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate
0.027
thymidine
-
-
0.036
[(1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl]methyl acetate
-
with dGMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
0.206
[(1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl]methyl acetate
-
with TMP as substrate, in Tris-HCl (50 mM, pH 7.2), phosphoenolpyruvate (0.5 mM), KCl (40 mM), MgCl2 (2 mM), at 30°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000003 - 0.0000137
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
0.0000003 - 0.0000183
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
0.018 - 0.2
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0051 - 0.2
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0026
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0015
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0001 - 0.0006
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.001 - 0.0019
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0001 - 0.0021
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.00015 - 0.0012
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0032
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0085
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.000028
(S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00001
(S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0003 - 0.0027
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
0.0013 - 0.035
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.009 - 0.143
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.138
1-(1-benzylpiperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.00095 - 0.00096
1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.328
1-(1-[[4-(dimethylamino)phenyl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.066
1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.152
1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.058
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
1.115
1-[1-(cyclohexylmethyl)piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.023
1-[1-[(1-benzofuran-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0071 - 0.06045
1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.04
1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.113
1-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0018
1-[1-[(7-chloro-4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.114
1-[1-[(furan-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.254
1-[1-[(furan-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.027
1-[1-[(isoquinolin-1-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.026
1-[1-[(isoquinolin-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.025
1-[1-[(isoquinolin-4-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.00088
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0013
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.005
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.002
2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0000001 - 0.0000005
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
0.0000003 - 0.0000013
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
0.0000006 - 0.0000028
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000001 - 0.0000011
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.000003
2-(3-chlorophenoxy)-3-methoxy-4-[(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl]benzoic acid
Staphylococcus aureus
-
temperature not specified in the publication, pH not specified in the publication
0.0000001 - 0.0000016
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
0.000001 - 0.0000025
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.0000006 - 0.0000083
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000001 - 0.0000007
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.0000003 - 0.0000007
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
0.0000003 - 0.000001
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
0.0000001 - 0.000003
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
0.0000006 - 0.0000012
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000002 - 0.000018
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000006 - 0.0000293
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.0000002 - 0.0000135
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.00025
2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.012
2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00044
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.002
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00016
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00051
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0058
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00012
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0062
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0029
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0026
3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0024
3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0000003
4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0027
4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.000002
4-[3-cyano-2-oxo-7-(1H-pyrazol-4-yl)-5,6-dihydro-1H-benzo[h]quinolin-4-yl]benzoic acid
Mycobacterium tuberculosis
pH 7.5, 37°C
0.00042
4-[3-cyano-6-(3-methoxyphenyl)-2-oxo-1H-pyridin-4-yl]benzoic acid
Mycobacterium tuberculosis
pH 7.5, 37°C
0.141
4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzoic acid
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.035
4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzonitrile
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.015 - 0.024
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
0.142
5-methyl-1-(1-[[4-(1H-tetrazol-5-yl)phenyl]methyl]piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.72
5-methyl-1-(2-[methyl[(3-phenoxyphenyl)methyl]amino]ethyl)pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.01
5-methyl-1-[(3S)-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.129
5-methyl-1-[1-(2-phenylethyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.235
5-methyl-1-[1-(3-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0029 - 0.156
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
0.353
5-methyl-1-[1-(4-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.072
5-methyl-1-[1-[(3-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.944
5-methyl-1-[1-[(3-phenoxyphenyl)methyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0061
5-methyl-1-[1-[(3-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.168
5-methyl-1-[1-[(4-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.029
5-methyl-1-[1-[(4-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0011 - 0.03251
5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
0.038
5-methyl-1-[1-[(naphthalen-1-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.02
5-methyl-1-[1-[(naphthalen-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.098
5-methyl-1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.075
5-methyl-1-[1-[(pyridin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.049
5-methyl-1-[1-[(pyridin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.009
5-methyl-1-[1-[(quinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.017
5-methyl-1-[1-[(quinolin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.025
5-methyl-1-[1-[(quinolin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
1.91
5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.011
5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
1.14
5-methyl-1-[1-[3-(3-phenoxyphenyl)propyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.006 - 0.059
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
0.143
5-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]pyridine-2-carboxylic acid
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.2
6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.037
6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.013
6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.063
6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.011
6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0049
6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.021
6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.14
albendazole
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
0.01
D-2'-fluoroarabinosyl-5-methyldeoxyuridine
Bacillus anthracis
pH 7.6, 37°C
0.02
deoxy-fluorothymidine
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.75
diethylcarbamazine
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
155
guanidine hydrochloride
Wolbachia endosymbiont of Brugia malayi
pH 7.4, 37°C
0.15
ivermectin
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
1.2
levamisole
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
0.00037
methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.104
N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.068
N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.003
N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0023
N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00088
N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0032
N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0026
N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0034
N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00099
N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0002
N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0022
N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0032
N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00012
N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00081
N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0021
N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.001
N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0022
N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.018
suramin
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
0.0000002 - 0.0000008
TK-666
600
Urea
Wolbachia endosymbiont of Brugia malayi
pH 7.4, 37°C
0.000003
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000137
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000003
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000183
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.018
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
IC50 above 0.2 mM, pH and temperature not specified in the publication
0.0051
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
IC50 above 0.2 mM, pH and temperature not specified in the publication
0.0004
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0026
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0004
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0015
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0001
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0006
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.001
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0019
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0001
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0021
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00015
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0012
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0004
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0032
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0004
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0085
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0003
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0027
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0013
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.035
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.009
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.143
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.00095
1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.00096
1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0071
1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.06045
1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0000001
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
Streptococcus pneumoniae
-
IC50 below 0.1 nM, pH and temperature not specified in the publication
0.0000005
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000003
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000013
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000006
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000028
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000001
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000011
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000001
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
Streptococcus pneumoniae
-
IC50 below 0.1 nM, pH and temperature not specified in the publication
0.0000016
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.000001
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000025
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000006
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000083
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000001
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Streptococcus pneumoniae
-
IC50 below 0.1 nM, pH and temperature not specified in the publication
0.0000007
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000003
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000007
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000003
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.000001
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000001
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.000003
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
Staphylococcus aureus
-
IC50 below 3 nM, pH and temperature not specified in the publication
0.0000006
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000012
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000002
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Streptococcus pneumoniae
-
IC50 below 0.2 nM, pH and temperature not specified in the publication
0.000018
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000006
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000293
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000002
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000135
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.015
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.024
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0029
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0034
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.124
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.156
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0011
5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.03251
5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.006
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.059
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
Staphylococcus aureus
-
pH and temperature not specified in the publication
0.0000002
TK-666
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0000008
TK-666
Staphylococcus aureus
-
pH and temperature not specified in the publication
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Purification and some properties of thymidylate kinase from sea urchin
Biochemistry
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Homo sapiens
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4
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Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors
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22
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2003
Mycobacterium tuberculosis
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Gardberg, A.; Shuvalova, L.; Monnerjahn, C.; Konrad, M.; Lavie, A.
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases
Structure
11
1265-1277
2003
Equid alphaherpesvirus 4, Herpes simplex virus
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Van Daele, I.; Munier-Lehmann, H.; Hendrickx, P.M.; Marchal, G.; Chavarot, P.; Froeyen, M.; Qing, L.; Martins, J.C.; Van Calenbergh, S.
Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase
ChemMedChem
1
1081-1090
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis
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Alexandre, J.A.; Roy, B.; Topalis, D.; Pochet, S.; Perigaud, C.; Deville-Bonne, D.
Enantioselectivity of human AMP, dTMP and UMP-CMP kinases
Nucleic Acids Res.
35
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2007
Homo sapiens (P23919)
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Kotaka, M.; Dhaliwal, B.; Ren, J.; Nichols, C.E.; Angell, R.; Lockyer, M.; Hawkins, A.R.; Stammers, D.K.
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding
Protein Sci.
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2006
Staphylococcus aureus
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Gasse, C.; Douguet, D.; Huteau, V.; Marchal, G.; Munier-Lehmann, H.; Pochet, S.
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity
Bioorg. Med. Chem.
16
6075-6085
2008
Homo sapiens, Mycobacterium tuberculosis
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Hu, C.M.; Chang, Z.F.
Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status
Cancer Res.
68
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2008
Homo sapiens
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Familiar, O.; Munier-Lehmann, H.; Negri, A.; Gago, F.; Douguet, D.; Rigouts, L.; Hernandez, A.I.; Camarasa, M.J.; Perez-Perez, M.J.
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
ChemMedChem
3
1083-1093
2008
Homo sapiens, Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
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Collins, C.M.; Olstad, K.; Sterud, E.; Jones, C.S.; Noble, L.R.; Mo, T.A.; Cunningham, C.O.
Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris
Fish Shellfish Immunol.
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2007
Salmo salar
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Chen, Y.L.; Lin, D.W.; Chang, Z.F.
Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation
Genes Cells
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679-689
2008
Homo sapiens
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Kandeel, M.; Kitade, Y.
Molecular characterization, heterologous expression and kinetic analysis of recombinant Plasmodium falciparum thymidylate kinase
J. Biochem.
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2008
Plasmodium falciparum
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Lavie, A.; Su, Y.; Ghassemi, M.; Novak, R.M.; Caffrey, M.; Sekulic, N.; Monnerjahn, C.; Konrad, M.; Cook, J.L.
Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells
J. Gen. Virol.
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2008
Escherichia coli, Homo sapiens
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Van Daele, I.; Munier-Lehmann, H.; Froeyen, M.; Balzarini, J.; Van Calenbergh, S.
Rational design of 5-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth
J. Med. Chem.
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2007
Homo sapiens, Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
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Sato, T.; Neschadim, A.; Konrad, M.; Fowler, D.H.; Lavie, A.; Medin, J.A.
Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy
Mol. Ther.
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2007
Homo sapiens
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Byun, Y.; Vogel, S.R.; Phipps, A.J.; Carnrot, C.; Eriksson, S.; Tiwari, R.; Tjarks, W.
Synthesis and Biological Evaluation of Inhibitors of Thymidine Monophosphate Kinase from Bacillus anthracis
Nucleosides Nucleotides Nucleic Acids
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244-260
2008
Bacillus anthracis
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Ronceret, A.; Gadea-Vacas, J.; Guilleminot, J.; Lincker, F.; Delorme, V.; Lahmy, S.; Pelletier, G.; Chaboute, M.E.; Devic, M.
The first zygotic division in Arabidopsis requires de novo transcription of thymidylate kinase
Plant J.
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2008
Arabidopsis thaliana (A0NAB2)
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Carnrot, C.; Wang, L.; Topalis, D.; Eriksson, S.
Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase
Protein Sci.
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Bacillus anthracis (Q81W11), Bacillus anthracis
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Hu, C.M.; Chang, Z.F.
A bioluminescent method for measuring thymidylate kinase activity suitable for high-throughput screening of inhibitor
Anal. Biochem.
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2010
Homo sapiens
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Chien, C.Y.; Chen, B.R.; Chou, C.K.; Sclafani, R.A.; Su, J.Y.
The yeast Cdc8 exhibits both deoxythymidine monophosphate and diphosphate kinase activities
FEBS Lett.
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2009
Saccharomyces cerevisiae
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Andrade, C.H.; Pasqualoto, K.F.; Ferreira, E.I.; Hopfinger, A.J.
Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors
J. Chem. Inf. Model.
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Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
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Kohler, J.J.; Hosseini, S.H.; Cucoranu, I.; Zhelyabovska, O.; Green, E.; Ivey, K.; Abuin, A.; Fields, E.; Hoying, A.; Russ, R.; Santoianni, R.; Raper, C.M.; Yang, Q.; Lavie, A.; Lewis, W.
Transgenic cardiac-targeted overexpression of human thymidylate kinase
Lab. Invest.
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2010
Homo sapiens
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Kandeel, M.; Kato, A.; Kitamura, Y.; Kitade, Y.
Thymidylate kinase: the lost chemotherapeutic target
Nucleic Acids Symp. Ser.
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283-284
2009
Plasmodium falciparum, Anaplasma marginale
brenda
Meyer, P.; Caillat, C.; Topalis, D.; Balzarini, J.; Deville-Bonne, D.
Structural basis for the specificity of thymidylate kinases from human pathogens: implications for nucleotide analogues activation
Nucleic Acids Symp. Ser.
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2009
unidentified poxvirus
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Caillat, C.; Topalis, D.; Agrofoglio, L.A.; Pochet, S.; Balzarini, J.; Deville-Bonne, D.; Meyer, P.
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy
Proc. Natl. Acad. Sci. USA
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2008
Vaccinia virus (P68693), Vaccinia virus
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Wayengera, M.
Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays
Theor. Biol. Med. Model.
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2009
Mycobacterium tuberculosis
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Leibly, D.J.; Abendroth, J.; Bryan, C.M.; Sankaran, B.; Kelley, A.; Barrett, L.K.; Stewart, L.; Van Voorhis, W.C.
Structure of thymidylate kinase from Ehrlichia chaffeensis
Acta Crystallogr. Sect. F
67
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2011
Ehrlichia chaffeensis (Q2GHN3)
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Kandeel, M.; Kitade, Y.
The substrate binding preferences of Plasmodium thymidylate kinase
Biol. Pharm. Bull.
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2011
Plasmodium falciparum
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Van Poecke, S.; Munier-Lehmann, H.; Helynck, O.; Froeyen, M.; Van Calenbergh, S.
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase
Bioorg. Med. Chem.
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2011
Mycobacterium tuberculosis
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Toti, K.S.; Verbeke, F.; Risseeuw, M.D.; Frecer, V.; Munier-Lehmann, H.; Van Calenbergh, S.
Synthesis and evaluation of 5-modified thymidines and 5-hydroxymethyl-2-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors
Bioorg. Med. Chem.
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2013
Mycobacterium tuberculosis
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Familiar, O.; Munier-Lehmann, H.; Ainsa, J.A.; Camarasa, M.J.; Perez-Perez, M.J.
Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone
Eur. J. Med. Chem.
45
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2010
Mycobacterium tuberculosis
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Topalis, D.; Pradere, U.; Roy, V.; Caillat, C.; Azzouzi, A.; Broggi, J.; Snoeck, R.; Andrei, G.; Lin, J.; Eriksson, S.; Alexandre, J.A.; El-Amri, C.; Deville-Bonne, D.; Meyer, P.; Balzarini, J.; Agrofoglio, L.A.
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
J. Med. Chem.
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2011
Homo sapiens (P23919), Homo sapiens
brenda
Martinez-Botella, G.; Breen, J.N.; Duffy, J.E.; Dumas, J.; Geng, B.; Gowers, I.K.; Green, O.M.; Guler, S.; Hentemann, M.F.; Hernandez-Juan, F.A.; Joseph-McCarthy, D.; Kawatkar, S.; Larsen, N.A.; Lazari, O.; Loch, J.T.; Macritchie, J.A.; McKenzie, A.R.; Newman, J.V.; Olivier, N.B.; Otterson, L.G.; Owens, A.P.
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK)
J. Med. Chem.
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2012
Streptococcus pneumoniae, Staphylococcus aureus
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Choi, J.Y.; Plummer, M.S.; Starr, J.; Desbonnet, C.R.; Soutter, H.; Chang, J.; Miller, J.R.; Dillman, K.; Miller, A.A.; Roush, W.R.
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation
J. Med. Chem.
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2012
Pseudomonas aeruginosa (Q9HZN8)
brenda
Kumar, M.; Sharma, S.; Srinivasan, A.; Singh, T.P.; Kaur, P.
Structure-based in-silico rational design of a selective peptide inhibitor for thymidine monophosphate kinase of Mycobacterium tuberculosis
J. Mol. Model.
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2011
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
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Kato, A.; Yasuda, Y.; Kitamura, Y.; Kandeel, M.; Kitade, Y.
Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK)
Parasitol. Int.
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2012
Plasmodium falciparum
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Guevara-Hernandez, E.; Garcia-Orozco, K.D.; Sotelo-Mundo, R.R.
Biochemical characterization of thymidine monophosphate kinase from white spot syndrome virus: a functional domain from the viral ORF454
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2012
white spot syndrome virus
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Chaudhary, S.K.; Jeyakanthan, J.; Sekar, K.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of thymidylate kinase (TTHA1607) from Thermus thermophilus HB8
Acta Crystallogr. Sect. F
69
118-121
2013
Thermus thermophilus (Q5SHX3), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SHX3)
brenda
Doharey, P.K.; Suthar, M.K.; Verma, A.; Kumar, V.; Yadav, S.; Balaramnavar, V.M.; Rathaur, S.; Saxena, A.K.; Siddiqi, M.I.; Saxena, J.K.
Molecular cloning and characterization of Brugia malayi thymidylate kinase
Acta Trop.
133
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2014
Wolbachia endosymbiont of Brugia malayi (Q5GTD5), Wolbachia endosymbiont of Brugia malayi TRS (Q5GTD5)
brenda
Singh, V.K.; Doharey, P.K.; Kumar, V.; Saxena, J.K.; Siddiqi, M.I.; Rathaur, S.; Narender, T.
Synthesis, molecular docking and Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition study of novel derivatives of [6]-shogaol
Eur. J. Med. Chem.
93
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2015
Wolbachia endosymbiont of Brugia malayi (Q5GTD5), Wolbachia endosymbiont of Brugia malayi TRS (Q5GTD5)
brenda
Doharey, P.K.; Singh, S.K.; Verma, P.; Verma, A.; Rathaur, S.; Saxena, J.K.
Insights into the structure-function relationship of Brugia malayi thymidylate kinase (BmTMK)
Int. J. Biol. Macromol.
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565-571
2016
Wolbachia endosymbiont of Brugia malayi (Q5GTD5), Wolbachia endosymbiont of Brugia malayi TRS (Q5GTD5)
brenda
Guevara-Hernandez, E.; Arvizu-Flores, A.A.; Lugo-Sanchez, M.E.; Velazquez-Contreras, E.F.; Castillo-Yanez, F.J.; Brieba, L.G.; Sotelo-Mundo, R.R.
A novel viral thymidylate kinase with dual kinase activity
J. Bioenerg. Biomembr.
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431-440
2015
white spot syndrome virus
brenda
Kawatkar, S.P.; Keating, T.A.; Olivier, N.B.; Breen, J.N.; Green, O.M.; Guler, S.Y.; Hentemann, M.F.; Loch, J.T.; McKenzie, A.R.; Newman, J.V.; Otterson, L.G.; Martinez-Botella, G.
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region
J. Med. Chem.
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4584-4597
2014
Staphylococcus aureus
brenda
Naik, M.; Raichurkar, A.; Bandodkar, B.S.; Varun, B.V.; Bhat, S.; Kalkhambkar, R.; Murugan, K.; Menon, R.; Bhat, J.; Paul, B.; Iyer, H.; Hussein, S.; Tucker, J.A.; Vogtherr, M.; Embrey, K.J.; McMiken, H.; Prasad, S.; Gill, A.; Ugarkar, B.G.; Venkatraman, J.; Read, J.; Panda, M.
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors
J. Med. Chem.
58
753-766
2015
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis H37Rv (P9WKE1)
brenda
Noguchi, Y.; Yasuda, Y.; Tashiro, M.; Kataoka, T.; Kitamura, Y.; Kandeel, M.; Kitade, Y.
Synthesis of carbocyclic pyrimidine nucleosides and their inhibitory activities against Plasmodium falciparum thymidylate kinase
Parasitol. Int.
62
368-371
2013
Plasmodium falciparum
brenda
Sato, T.; Neschadim, A.; Lavie, A.; Yanagisawa, T.; Medin, J.A.
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer
PLoS ONE
8
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2013
Homo sapiens
brenda
Keita, M.; Kumar, A.; Dali, B.; Megnassan, E.; Siddiqi, M.; Frecer, V.; Miertus, S.
Quantitative structure-activity relationships and design of thymine-like inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis with favourable pharmacokinetic profiles
RSC Adv.
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55853-55866
2014
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis H37Rv (P9WKE1)
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Fucci, I.J.; Sinha, K.; Rule, G.S.
Stabilization of active site dynamics leads to increased activity with 3-azido-3-deoxythymidine monophosphate for F105Y mutant human thymidylate kinase
ACS Omega
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2355-2367
2020
Homo sapiens (P23919)
brenda
Chaudhary, S.K.; Jeyakanthan, J.; Sekar, K.
Structural and functional roles of dynamically correlated residues in thymidylate kinase
Acta Crystallogr. Sect. D
74
341-354
2018
Thermus thermophilus (Q5SHX3), Thermus thermophilus ATCC 27634 (Q5SHX3)
brenda
Sinha, K.; Rule, G.S.
The structure of thymidylate kinase from Candida albicans reveals a unique structural element
Biochemistry
56
4360-4370
2017
Candida albicans (Q59TV7), Candida albicans ATCC MYA-2876 (Q59TV7)
brenda
Chen, M.D.; Sinha, K.; Rule, G.S.; Ly, D.H.
Interaction of alpha-thymidine inhibitors with thymidylate kinase from Plasmodium falciparum
Biochemistry
57
2868-2875
2018
Plasmodium falciparum (Q8I4S1), Plasmodium falciparum, Plasmodium falciparum isolate 3D7 (Q8I4S1)
brenda
Chen, M.D.; Fucci, I.J.; Sinha, K.; Rule, G.S.
dGMP binding to thymidylate kinase from Plasmodium falciparum shows half-site binding and induces protein dynamics at the dimer interface
Biochemistry
59
694-703
2020
Plasmodium falciparum
brenda
Biswas, A.; Jasti, S.; Jeyakanthan, J.; Sekar, K.
Role of sequence evolution and conformational dynamics in the substrate specificity and oligomerization mode of thymidylate kinases
J. Biomol. Struct. Dyn.
35
2136-2154
2017
Sulfurisphaera tokodaii (Q970Q8), Sulfurisphaera tokodaii DSM 16993 (Q970Q8)
brenda
Song, L.; Merceron, R.; Gracia, B.; Quintana, A.L.; Risseeuw, M.D.P.; Hulpia, F.; Cos, P.; Ainsa, J.A.; Munier-Lehmann, H.; Savvides, S.N.; Van Calenbergh, S.
Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors
J. Med. Chem.
61
2753-2775
2018
Mycobacterium tuberculosis (A5U7S1), Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKE1)
brenda
Biswas, A.; Shukla, A.; Vijayan, R.S.K.; Jeyakanthan, J.; Sekar, K.
Crystal structures of an archaeal thymidylate kinase from Sulfolobus tokodaii provide insights into the role of a conserved active site arginine residue
J. Struct. Biol.
197
236-249
2017
Sulfurisphaera tokodaii (Q970Q8), Sulfurisphaera tokodaii DSM 16993 (Q970Q8)
brenda
Frisk, J.H.; Eriksson, S.; Pejler, G.; Wang, L.
Identification of a novel thymidylate kinase activity
Nucleosides Nucleotides Nucleic Acids
39
1359-1368
2020
Homo sapiens, Homo sapiens (P23919)
brenda
Najera-Martinez, M.; Pedroza-Garcia, J.; Suzuri-Hernandez, L.; Mazubert, C.; Drouin-Wahbi, J.; Vazquez-Ramos, J.; Raynaud, C.; Plasencia, J.
Maize thymidine kinase activity is present throughout plant development and its heterologous expression confers tolerance to an organellar DNA-damaging agent
Plants (Basel)
9
1-14
2020
Zea mays (B0R217)
brenda
Kandeel, M.; Kitade, Y.; Al-Taher, A.; Al-Nazawi, M.
The structural basis of unique substrate recognition by Plasmodium thymidylate kinase Molecular dynamics simulation and inhibitory studies
PLoS ONE
14
e0212065
2019
Plasmodium falciparum (Q8I4S1), Plasmodium falciparum
brenda