Sequence of KMT5A_HUMAN

[histone H4]-lysine20 N-methyltransferase

Q9NQR1

393

42890

51866

Nishioka K.,Rice J.C.,Sarma K.,Erdjument-Bromage H.,Werner J.,Wang Y.,Chuikov S.,Valenzuela P.,Tempst P.,Steward R.,Lis J.T.,Allis C.D.,Reinberg D.

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.

Mol. Cell

9

1201-1213

2002

51867

Fang J.,Feng Q.,Ketel C.S.,Wang H.,Cao R.,Xia L.,Erdjument-Bromage H.,Tempst P.,Simon J.A.,Zhang Y.

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.

Curr. Biol.

12

1086-1099

2002

51869

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

51870

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

51871

Rice J.C.,Nishioka K.,Sarma K.,Steward R.,Reinberg D.,Allis C.D.

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.

Genes Dev.

16

2225-2230

2002

51872

Julien E.,Herr W.

A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1.

Mol. Cell

14

713-725

2004

51873

Yin Y.,Liu C.,Tsai S.N.,Zhou B.,Ngai S.M.,Zhu G.

SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.

J. Biol. Chem.

280

30025-30031

2005

51874

Sims J.K.,Houston S.I.,Magazinnik T.,Rice J.C.

A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin.

J. Biol. Chem.

281

12760-12766

2006

51875

Shi X.,Kachirskaia I.,Yamaguchi H.,West L.E.,Wen H.,Wang E.W.,Dutta S.,Appella E.,Gozani O.

Modulation of p53 function by SET8-mediated methylation at lysine 382.

Mol. Cell

27

636-646

2007

51876

Kalakonda N.,Fischle W.,Boccuni P.,Gurvich N.,Hoya-Arias R.,Zhao X.,Miyata Y.,Macgrogan D.,Zhang J.,Sims J.K.,Rice J.C.,Nimer S.D.

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1.

Oncogene

27

4293-4304

2008

51877

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

51878

West L.E.,Roy S.,Lachmi-Weiner K.,Hayashi R.,Shi X.,Appella E.,Kutateladze T.G.,Gozani O.

The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.

J. Biol. Chem.

285

37725-37732

2010

51879

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

51880

Serrano L.,Martinez-Redondo P.,Marazuela-Duque A.,Vazquez B.N.,Dooley S.J.,Voigt P.,Beck D.B.,Kane-Goldsmith N.,Tong Q.,Rabanal R.M.,Fondevila D.,Munoz P.,Kruger M.,Tischfield J.A.,Vaquero A.

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.

Genes Dev.

27

639-653

2013

51881

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

51882

Abbas T.,Mueller A.C.,Shibata E.,Keaton M.,Rossi M.,Dutta A.

CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

Mol. Cell

49

1147-1158

2013

51883

Saredi G.,Huang H.,Hammond C.M.,Alabert C.,Bekker-Jensen S.,Forne I.,Reveron-Gomez N.,Foster B.M.,Mlejnkova L.,Bartke T.,Cejka P.,Mailand N.,Imhof A.,Patel D.J.,Groth A.

H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex.

Nature

534

714-718

2016

51884

Xiao B.,Jing C.,Kelly G.,Walker P.A.,Muskett F.W.,Frenkiel T.A.,Martin S.R.,Sarma K.,Reinberg D.,Gamblin S.J.,Wilson J.R.

Specificity and mechanism of the histone methyltransferase Pr-Set7.

Genes Dev.

19

1444-1454

2005

51885

Couture J.-F.,Collazo E.,Brunzelle J.S.,Trievel R.C.

Structural and functional analysis of SET8, a histone H4 'Lys-20' methyltransferase.

Genes Dev.

19

1455-1465

2005