Sequence of LOVG_ASPTN
EC Number:3.1.2.31
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
Q0C8M2
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
256
28932
Reaction
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
Other sequences found for EC No. 3.1.2.31
General information:
Sequence
0 MRYQASPALA KAPRALLCIH GAGCSPAIFR VQLSKLRAAL REDFEFVYVT APFPSSAGPG
60 ILPVFADLGP YYSWFESSSG NNNNGPSVGE RLAAVHDPIR RTIVDWQTQH PHIPIVGAIG
120 FSEGALVTTL LLWQQQMGRL PWLPRMSVAM LICPWYQDEA SQYMRNEVME NHDDDHDSKD
180 TEWQEELVIR IPTLHLQGRD DFALAGSKML VARHFSPREA QVLEFAGQHQ FPNRPRDVLE
240 VINRFRKLCV TVQTLE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
565336
Alberts A.W.,Chen J.,Kuron G.,Hunt V.,Huff J.,Hoffman C.,Rothrock J.,Lopez M.,Joshua H.,Harris E.,Patchett A.,Monaghan R.,Currie S.,Stapley E.,Albers-Schonberg G.,Hensens O.,Hirshfield J.,Hoogsteen K.,Liesch J.,Springer J.
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Proc. Natl. Acad. Sci. U.S.A.
77
3957-3961
1980
565337
Hendrickson L.,Davis C.R.,Roach C.,Nguyen D.K.,Aldrich T.,McAda P.C.,Reeves C.D.
Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene.
Chem. Biol.
6
429-439
1999
565338
Kennedy J.,Auclair K.,Kendrew S.G.,Park C.,Vederas J.C.,Hutchinson C.R.
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
Science
284
1368-1372
1999
565339
Sorensen J.L.,Auclair K.,Kennedy J.,Hutchinson C.R.,Vederas J.C.
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.
Org. Biomol. Chem.
1
50-59
2003
565340
Xie X.,Watanabe K.,Wojcicki W.A.,Wang C.C.,Tang Y.
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.
Chem. Biol.
13
1161-1169
2006
565341
Xie X.,Pashkov I.,Gao X.,Guerrero J.L.,Yeates T.O.,Tang Y.
Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.
Biotechnol. Bioeng.
102
20-28
2009
565342
Gao X.,Xie X.,Pashkov I.,Sawaya M.R.,Laidman J.,Zhang W.,Cacho R.,Yeates T.O.,Tang Y.
Directed evolution and structural characterization of a simvastatin synthase.
Chem. Biol.
16
1064-1074
2009
565343
Xie X.,Meehan M.J.,Xu W.,Dorrestein P.C.,Tang Y.
Acyltransferase mediated polyketide release from a fungal megasynthase.
J. Am. Chem. Soc.
131
8388-8389
2009
565344
Ma S.M.,Li J.W.,Choi J.W.,Zhou H.,Lee K.K.,Moorthie V.A.,Xie X.,Kealey J.T.,Da Silva N.A.,Vederas J.C.,Tang Y.
Complete reconstitution of a highly reducing iterative polyketide synthase.
Science
326
589-592
2009
565345
Meehan M.J.,Xie X.,Zhao X.,Xu W.,Tang Y.,Dorrestein P.C.
FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.
Biochemistry
50
287-299
2011
565346
Barriuso J.,Nguyen D.T.,Li J.W.,Roberts J.N.,MacNevin G.,Chaytor J.L.,Marcus S.L.,Vederas J.C.,Ro D.K.
Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.
J. Am. Chem. Soc.
133
8078-8081
2011
565347
Ames B.D.,Nguyen C.,Bruegger J.,Smith P.,Xu W.,Ma S.,Wong E.,Wong S.,Xie X.,Li J.W.,Vederas J.C.,Tang Y.,Tsai S.C.
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc. Natl. Acad. Sci. U.S.A.
109
11144-11149
2012
565348
Xu W.,Chooi Y.H.,Choi J.W.,Li S.,Vederas J.C.,Da Silva N.A.,Tang Y.
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
Angew. Chem. Int. Ed. Engl.
52
6472-6475
2013
565349
Jimenez-Oses G.,Osuna S.,Gao X.,Sawaya M.R.,Gilson L.,Collier S.J.,Huisman G.W.,Yeates T.O.,Tang Y.,Houk K.N.
The role of distant mutations and allosteric regulation on LovD active site dynamics.
Nat. Chem. Biol.
10
431-436
2014
565350
Chen M.C.,Tsai Y.C.,Tseng J.H.,Liou J.J.,Horng S.,Wen H.C.,Fan Y.C.,Zhong W.B.,Hsu S.P.
Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer.
Int. J. Mol. Sci.
18
0-0
2017
565351
Zhong W.B.,Tsai Y.C.,Chin L.H.,Tseng J.H.,Tang L.W.,Horng S.,Fan Y.C.,Hsu S.P.
A synergistic anti-cancer effect of troglitazone and lovastatin in a human anaplastic thyroid cancer cell line and in a mouse xenograft model.
Int. J. Mol. Sci.
19
0-0
2018
