Information on EC 3.1.2.31 - dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase

for references in articles please use BRENDA:EC3.1.2.31
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EC Tree
IUBMB Comments
Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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dihydromonacolin L-[lovastatin nonaketide synthase]
+
H2O
=
holo-[lovastatin nonaketide synthase]
+
dihydromonacolin L acid
dihydromonacolin L-[lovastatin nonaketide synthase]
+
=
holo-[lovastatin nonaketide synthase]
+
Synonyms
LovG, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
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