Sequence of KDM5B_HUMAN

[histone H3]-trimethyl-L-lysine4 demethylase

Q9UGL1

1544

175658

561475

Lu P.J.,Sundquist K.,Baeckstrom D.,Poulsom R.,Hanby A.,Meier-Ewert S.,Jones T.,Mitchell M.,Pitha-Rowe P.,Freemont P.,Taylor-Papadimitriou J.

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.

J. Biol. Chem.

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1999

561476

Vogt T.,Kroiss M.,McClelland M.,Gruss C.,Becker B.,Bosserhoff A.K.,Rumpler G.,Bogenrieder T.,Landthaler M.,Stolz W.

Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer.

Lab. Invest.

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1999

561477

Kashuba V.,Protopopov A.,Podowski R.,Gizatullin R.,Li J.,Klein G.,Wahlestedt C.,Zabarovsky E.

Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A).

Eur. J. Hum. Genet.

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2000

561478

Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.

The DNA sequence and biological annotation of human chromosome 1.

Nature

441

315-321

2006

561479

Barrett A.,Madsen B.,Copier J.,Lu P.J.,Cooper L.,Scibetta A.G.,Burchell J.,Taylor-Papadimitriou J.

PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?

Int. J. Cancer

101

581-588

2002

561480

Tan K.,Shaw A.L.,Madsen B.,Jensen K.,Taylor-Papadimitriou J.,Freemont P.S.

Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9.

J. Biol. Chem.

278

20507-20513

2003

561481

Roesch A.,Becker B.,Meyer S.,Wild P.,Hafner C.,Landthaler M.,Vogt T.

Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas.

Mod. Pathol.

18

1249-1257

2005

561482

Roesch A.,Becker B.,Schneider-Brachert W.,Hagen I.,Landthaler M.,Vogt T.

Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells.

J. Invest. Dermatol.

126

1850-1859

2006

561483

Christensen J.,Agger K.,Cloos P.A.C.,Pasini D.,Rose S.,Sennels L.,Rappsilber J.,Hansen K.H.,Salcini A.E.,Helin K.

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

Cell

128

1063-1076

2007

561484

Secombe J.,Li L.,Carlos L.,Eisenman R.N.

The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.

Genes Dev.

21

537-551

2007

561485

Barrett A.,Santangelo S.,Tan K.,Catchpole S.,Roberts K.,Spencer-Dene B.,Hall D.,Scibetta A.,Burchell J.,Verdin E.,Freemont P.,Taylor-Papadimitriou J.

Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases.

Int. J. Cancer

121

265-275

2007

561486

Yamane K.,Tateishi K.,Klose R.J.,Fang J.,Fabrizio L.A.,Erdjument-Bromage H.,Taylor-Papadimitriou J.,Tempst P.,Zhang Y.

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.

Mol. Cell

25

801-812

2007

561487

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

561488

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

561489

Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.

Uncovering global SUMOylation signaling networks in a site-specific manner.

Nat. Struct. Mol. Biol.

21

927-936

2014

561490

Xiao Z.,Chang J.G.,Hendriks I.A.,Sigurdsson J.O.,Olsen J.V.,Vertegaal A.C.

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

Mol. Cell. Proteomics

14

1419-1434

2015

561491

Horton J.R.,Engstrom A.,Zoeller E.L.,Liu X.,Shanks J.R.,Zhang X.,Johns M.A.,Vertino P.M.,Fu H.,Cheng X.

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

J. Biol. Chem.

291

2631-2646

2016

561492

Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

Nat. Struct. Mol. Biol.

24

325-336

2017

561493

Faundes V.,Newman W.G.,Bernardini L.,Canham N.,Clayton-Smith J.,Dallapiccola B.,Davies S.J.,Demos M.K.,Goldman A.,Gill H.,Horton R.,Kerr B.,Kumar D.,Lehman A.,McKee S.,Morton J.,Parker M.J.,Rankin J.,Robertson L.,Temple I.K.,Banka S.

Histone lysine methylases and demethylases in the landscape of human developmental disorders.

Am. J. Hum. Genet.

102

175-187

2018

561494

Martin H.C.,Jones W.D.,McIntyre R.,Sanchez-Andrade G.,Sanderson M.,Stephenson J.D.,Jones C.P.,Handsaker J.,Gallone G.,Bruntraeger M.,McRae J.F.,Prigmore E.,Short P.,Niemi M.,Kaplanis J.,Radford E.J.,Akawi N.,Balasubramanian M.,Dean J.,Horton R.,Hulbert A.,Johnson D.S.,Johnson K.,Kumar D.,Lynch S.A.,Mehta S.G.,Morton J.,Parker M.J.,Splitt M.,Turnpenny P.D.,Vasudevan P.C.,Wright M.,Bassett A.,Gerety S.S.,Wright C.F.,FitzPatrick D.R.,Firth H.V.,Hurles M.E.,Barrett J.C.

Quantifying the contribution of recessive coding variation to developmental disorders.

Science

362

1161-1164

2018

561495

Zhang Y.,Yang H.,Guo X.,Rong N.,Song Y.,Xu Y.,Lan W.,Zhang X.,Liu M.,Xu Y.,Cao C.

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.

Protein Cell

5

837-850

2014

561496

Bavetsias V.,Lanigan R.M.,Ruda G.F.,Atrash B.,McLaughlin M.G.,Tumber A.,Mok N.Y.,Le Bihan Y.V.,Dempster S.,Boxall K.J.,Jeganathan F.,Hatch S.B.,Savitsky P.,Velupillai S.,Krojer T.,England K.S.,Sejberg J.,Thai C.,Donovan A.,Pal A.,Scozzafava G.,Bennett J.M.,Kawamura A.,Johansson C.,Szykowska A.,Gileadi C.,Burgess-Brown N.A.,von Delft F.,Oppermann U.,Walters Z.,Shipley J.,Raynaud F.I.,Westaway S.M.,Prinjha R.K.,Fedorov O.,Burke R.,Schofield C.J.,Westwood I.M.,Bountra C.,Muller S.,van Montfort R.L.,Brennan P.E.,Blagg J.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

J. Med. Chem.

59

1388-1409

2016

561497

Johansson C.,Velupillai S.,Tumber A.,Szykowska A.,Hookway E.S.,Nowak R.P.,Strain-Damerell C.,Gileadi C.,Philpott M.,Burgess-Brown N.,Wu N.,Kopec J.,Nuzzi A.,Steuber H.,Egner U.,Badock V.,Munro S.,LaThangue N.B.,Westaway S.,Brown J.,Athanasou N.,Prinjha R.,Brennan P.E.,Oppermann U.

Structural analysis of human KDM5B guides histone demethylase inhibitor development.

Nat. Chem. Biol.

12

539-545

2016

561498

Tumber A.,Nuzzi A.,Hookway E.S.,Hatch S.B.,Velupillai S.,Johansson C.,Kawamura A.,Savitsky P.,Yapp C.,Szykowska A.,Wu N.,Bountra C.,Strain-Damerell C.,Burgess-Brown N.A.,Ruda G.F.,Fedorov O.,Munro S.,England K.S.,Nowak R.P.,Schofield C.J.,La Thangue N.B.,Pawlyn C.,Davies F.,Morgan G.,Athanasou N.,Muller S.,Oppermann U.,Brennan P.E.

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

Cell Chem. Biol.

24

371-380

2017