Sequence of GGT1_HUMAN
EC Number:2.3.2.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
Other sequences found for EC No. 2.3.2.2
General information:
Sequence
0 MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD
60 GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN
120 SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN
180 KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD
240 IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
300 ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD
360 DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE
420 MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA
480 TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF
540 IAVVQAIVRT AGGWAAASDS RKGGEPAGY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
548388
Rajpert-De Meyts E.,Heisterkamp N.,Groffen J.
Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.
Proc. Natl. Acad. Sci. U.S.A.
85
8840-8844
1988
548389
Sakamuro D.,Yamazoe M.,Matsuda Y.,Kangawa K.,Taniguchi N.,Matsuo H.,Yoshikawa H.,Ogasawara N.
The primary structure of human gamma-glutamyl transpeptidase.
Gene
73
1-9
1988
548390
Pitot H.C.,Goodspeed D.C.,Dunn T.J.,Hendrich S.,Maronpot R.R.,Moran S.
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Toxicol. Appl. Pharmacol.
97
23-34
1989
548391
Goodspeed D.C.,Dunn T.J.,Miller C.D.,Pitot H.C.
Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat.
Gene
76
1-9
1989
548392
Pawlak A.,Cohen E.H.,Octave J.-N.,Schweickhardt R.,Wu S.-J.,Bulle F.,Chikhi N.,Baik J.-H.,Siegrist S.,Guellaen G.
An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues.
J. Biol. Chem.
265
3256-3262
1990
548393
Courtay C.,Oster T.,Michelet F.,Visvikis A.,Diederich M.,Wellman M.,Siest G.
Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues.
Biochem. Pharmacol.
43
2527-2533
1992
548394
Wetmore L.A.,Gerard C.,Drazen J.M.
Human lung expresses unique gamma-glutamyl transpeptidase transcripts.
Proc. Natl. Acad. Sci. U.S.A.
90
7461-7465
1993
548395
Collins J.E.,Wright C.L.,Edwards C.A.,Davis M.P.,Grinham J.A.,Cole C.G.,Goward M.E.,Aguado B.,Mallya M.,Mokrab Y.,Huckle E.J.,Beare D.M.,Dunham I.
A genome annotation-driven approach to cloning the human ORFeome.
Genome Biol.
5
0-0
2004
548396
Dunham I.,Hunt A.R.,Collins J.E.,Bruskiewich R.,Beare D.M.,Clamp M.,Smink L.J.,Ainscough R.,Almeida J.P.,Babbage A.K.,Bagguley C.,Bailey J.,Barlow K.F.,Bates K.N.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Buck D.,Burgess J.,Burrill W.D.,Burton J.,Carder C.,Carter N.P.,Chen Y.,Clark G.,Clegg S.M.,Cobley V.E.,Cole C.G.,Collier R.E.,Connor R.,Conroy D.,Corby N.R.,Coville G.J.,Cox A.V.,Davis J.,Dawson E.,Dhami P.D.,Dockree C.,Dodsworth S.J.,Durbin R.M.,Ellington A.G.,Evans K.L.,Fey J.M.,Fleming K.,French L.,Garner A.A.,Gilbert J.G.R.,Goward M.E.,Grafham D.V.,Griffiths M.N.D.,Hall C.,Hall R.E.,Hall-Tamlyn G.,Heathcott R.W.,Ho S.,Holmes S.,Hunt S.E.,Jones M.C.,Kershaw J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.F.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Martyn I.D.,Mashreghi-Mohammadi M.,Matthews L.H.,Mccann O.T.,Mcclay J.,Mclaren S.,McMurray A.A.,Milne S.A.,Mortimore B.J.,Odell C.N.,Pavitt R.,Pearce A.V.,Pearson D.,Phillimore B.J.C.T.,Phillips S.H.,Plumb R.W.,Ramsay H.,Ramsey Y.,Rogers L.,Ross M.T.,Scott C.E.,Sehra H.K.,Skuce C.D.,Smalley S.,Smith M.L.,Soderlund C.,Spragon L.,Steward C.A.,Sulston J.E.,Swann R.M.,Vaudin M.,Wall M.,Wallis J.M.,Whiteley M.N.,Willey D.L.,Williams L.,Williams S.A.,Williamson H.,Wilmer T.E.,Wilming L.,Wright C.L.,Hubbard T.,Bentley D.R.,Beck S.,Rogers J.,Shimizu N.,Minoshima S.,Kawasaki K.,Sasaki T.,Asakawa S.,Kudoh J.,Shintani A.,Shibuya K.,Yoshizaki Y.,Aoki N.,Mitsuyama S.,Roe B.A.,Chen F.,Chu L.,Crabtree J.,Deschamps S.,Do A.,Do T.,Dorman A.,Fang F.,Fu Y.,Hu P.,Hua A.,Kenton S.,Lai H.,Lao H.I.,Lewis J.,Lewis S.,Lin S.-P.,Loh P.,Malaj E.,Nguyen T.,Pan H.,Phan S.,Qi S.,Qian Y.,Ray L.,Ren Q.,Shaull S.,Sloan D.,Song L.,Wang Q.,Wang Y.,Wang Z.,White J.,Willingham D.,Wu H.,Yao Z.,Zhan M.,Zhang G.,Chissoe S.,Murray J.,Miller N.,Minx P.,Fulton R.,Johnson D.,Bemis G.,Bentley D.,Bradshaw H.,Bourne S.,Cordes M.,Du Z.,Fulton L.,Goela D.,Graves T.,Hawkins J.,Hinds K.,Kemp K.,Latreille P.,Layman D.,Ozersky P.,Rohlfing T.,Scheet P.,Walker C.,Wamsley A.,Wohldmann P.,Pepin K.,Nelson J.,Korf I.,Bedell J.A.,Hillier L.W.,Mardis E.,Waterston R.,Wilson R.,Emanuel B.S.,Shaikh T.,Kurahashi H.,Saitta S.,Budarf M.L.,McDermid H.E.,Johnson A.,Wong A.C.C.,Morrow B.E.,Edelmann L.,Kim U.J.,Shizuya H.,Simon M.I.,Dumanski J.P.,Peyrard M.,Kedra D.,Seroussi E.,Fransson I.,Tapia I.,Bruder C.E.,O'Brien K.P.,Wilkinson P.,Bodenteich A.,Hartman K.,Hu X.,Khan A.S.,Lane L.,Tilahun Y.,Wright H.
The DNA sequence of human chromosome 22.
Nature
402
489-495
1999
548397
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
548398
Tate S.S.,Khadse V.,Wellner D.
Renal gamma-glutamyl transpeptidases: structural and immunological studies.
Arch. Biochem. Biophys.
262
397-408
1988
548399
Chikhi N.,Holic N.,Guellaen G.,Laperche Y.
Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.
Comp. Biochem. Physiol.
122B
367-380
1999
548400
Tate S.S.,Ross M.E.
Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit.
J. Biol. Chem.
252
6042-6045
1977
548401
Tate S.S.,Galbraith R.A.
In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase.
Biochem. Biophys. Res. Commun.
154
1167-1173
1988
548402
Ikeda Y.,Fujii J.,Taniguchi N.
Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis.
J. Biol. Chem.
268
3980-3985
1993
548403
Ikeda Y.,Fujii J.,Taniguchi N.,Meister A.
Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit.
J. Biol. Chem.
270
12471-12475
1995
548404
Ikeda Y.,Fujii J.,Anderson M.E.,Taniguchi N.,Meister A.
Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase.
J. Biol. Chem.
270
22223-22228
1995
548405
Ikeda Y.,Fujii J.,Taniguchi N.
Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase.
J. Biochem.
119
1166-1170
1996
548406
Kristiansen T.Z.,Bunkenborg J.,Gronborg M.,Molina H.,Thuluvath P.J.,Argani P.,Goggins M.G.,Maitra A.,Pandey A.
A proteomic analysis of human bile.
Mol. Cell. Proteomics
3
715-728
2004
548407
Castonguay R.,Halim D.,Morin M.,Furtos A.,Lherbet C.,Bonneil E.,Thibault P.,Keillor J.W.
Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase.
Biochemistry
46
12253-12262
2007
548408
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
548409
Wollscheid B.,Bausch-Fluck D.,Henderson C.,O'Brien R.,Bibel M.,Schiess R.,Aebersold R.,Watts J.D.
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Nat. Biotechnol.
27
378-386
2009
548410
West M.B.,Segu Z.M.,Feasley C.L.,Kang P.,Klouckova I.,Li C.,Novotny M.V.,West C.M.,Mechref Y.,Hanigan M.H.
Analysis of site-specific glycosylation of renal and hepatic gamma-glutamyl transpeptidase from normal human tissue.
J. Biol. Chem.
285
29511-29524
2010
548411
Wickham S.,West M.B.,Cook P.F.,Hanigan M.H.
Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.
Anal. Biochem.
414
208-214
2011
548412
West M.B.,Wickham S.,Parks E.E.,Sherry D.M.,Hanigan M.H.
Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling.
Antioxid. Redox Signal.
19
1877-1888
2013
548413
West M.B.,Chen Y.,Wickham S.,Heroux A.,Cahill K.,Hanigan M.H.,Mooers B.H.
Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme.
J. Biol. Chem.
288
31902-31913
2013
548414
Terzyan S.S.,Burgett A.W.,Heroux A.,Smith C.A.,Mooers B.H.,Hanigan M.H.
Human gamma-Glutamyl Transpeptidase 1: Structures of the free enzyme, inhibitor-bound tetrahedral transition states, and glutamate-bound enzyme reveal novel movement within the active site during catalysis.
J. Biol. Chem.
290
17576-17586
2015
548415
Dalli J.,Vlasakov I.,Riley I.R.,Rodriguez A.R.,Spur B.W.,Petasis N.A.,Chiang N.,Serhan C.N.
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.
Proc. Natl. Acad. Sci. U.S.A.
113
12232-12237
2016
548416
Darin N.,Leckstroem K.,Sikora P.,Lindgren J.,Almen G.,Asin-Cayuela J.
Gamma-glutamyl transpeptidase deficiency caused by a large homozygous intragenic deletion in GGT1.
Eur. J. Hum. Genet.
26
808-817
2018
