Sequence of CMAS3_MYCTU
EC Number:2.1.1.79
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cyclopropane-fatty-acyl-phospholipid synthase
P9WPB3
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
287
33028
Reaction
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
Other sequences found for EC No. 2.1.1.79
General information:
Sequence
0 MSVQLTPHFG NVQAHYDLSD DFFRLFLDPT QTYSCAYFER DDMTLQEAQI AKIDLALGKL
60 NLEPGMTLLD IGCGWGATMR RAIEKYDVNV VGLTLSENQA GHVQKMFDQM DTPRSRRVLL
120 EGWEKFDEPV DRIVSIGAFE HFGHQRYHHF FEVTHRTLPA DGKMLLHTIV RPTFKEGREK
180 GLTLTHELVH FTKFILAEIF PGGWLPSIPT VHEYAEKVGF RVTAVQSLQL HYARTLDMWA
240 TALEANKDQA IAIQSQTVYD RYMKYLTGCA KLFRQGYTDV DQFTLEK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
527939
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
527940
Glickman M.S.,Cox J.S.,Jacobs W.R. Jr.
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
Mol. Cell
5
717-727
2000
527941
Alahari A.,Trivelli X.,Guerardel Y.,Dover L.G.,Besra G.S.,Sacchettini J.C.,Reynolds R.C.,Coxon G.D.,Kremer L.
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PLoS ONE
2
0-0
2007
527942
Raman K.,Yeturu K.,Chandra N.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
BMC Syst. Biol.
2
109-109
2008
527943
Barkan D.,Liu Z.,Sacchettini J.C.,Glickman M.S.
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.
Chem. Biol.
16
499-509
2009
527944
Vaubourgeix J.,Bardou F.,Boissier F.,Julien S.,Constant P.,Ploux O.,Daffe M.,Quemard A.,Mourey L.
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.
J. Biol. Chem.
284
19321-19330
2009
527945
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
527946
Corrales R.M.,Molle V.,Leiba J.,Mourey L.,de Chastellier C.,Kremer L.
Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block.
J. Biol. Chem.
287
26187-26199
2012
527947
Huang C.-C.,Smith C.V.,Glickman M.S.,Jacobs W.R. Jr.,Sacchettini J.C.
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
J. Biol. Chem.
277
11559-11569
2002
