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Sequence of CATB_HUMAN

EC Number:3.4.22.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cathepsin B
P07858
Homo sapiens
339
37822
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
Other sequences found for EC No. 3.4.22.1

General information:

Sequence
show sequence in fasta format
  0 MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV DMSYLKRLCG
 60 TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR
120 ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC NGGYPAEAWN FWTRKGLVSG GLYESHVGCR
180 PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM
240 AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW
300 NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
523295
Chan S.J.,San Segundo B.,McCormick M.B.,Steiner D.F.
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.
Proc. Natl. Acad. Sci. U.S.A.
83
7721-7725
1986
523296
Cao L.,Taggart R.T.,Berquin I.M.,Moin K.,Fong D.,Sloane B.F.
Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.
Gene
139
163-169
1994
523297
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
523298
Otsuki T.,Ota T.,Nishikawa T.,Hayashi K.,Suzuki Y.,Yamamoto J.,Wakamatsu A.,Kimura K.,Sakamoto K.,Hatano N.,Kawai Y.,Ishii S.,Saito K.,Kojima S.,Sugiyama T.,Ono T.,Okano K.,Yoshikawa Y.,Aotsuka S.,Sasaki N.,Hattori A.,Okumura K.,Nagai K.,Sugano S.,Isogai T.
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
DNA Res.
12
117-126
2005
523300
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
523301
Ritonja A.,Popovic T.,Turk V.,Wiedenmann K.,Machleidt W.
Amino acid sequence of human liver cathepsin B.
FEBS Lett.
181
169-172
1985
523302
Moin K.,Day N.A.,Sameni M.,Hasnain S.,Hirama T.,Sloane B.F.
Human tumour cathepsin B. Comparison with normal liver cathepsin B.
Biochem. J.
285
427-434
1992
523303
Fong D.,Calhoun D.H.,Hsieh W.-T.,Lee B.,Wells R.D.
Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.
Proc. Natl. Acad. Sci. U.S.A.
83
2909-2913
1986
523304
Guo R.,Rowe P.S.,Liu S.,Simpson L.G.,Xiao Z.S.,Quarles L.D.
Inhibition of MEPE cleavage by Phex.
Biochem. Biophys. Res. Commun.
297
38-45
2002
523305
Basrur V.,Yang F.,Kushimoto T.,Higashimoto Y.,Yasumoto K.,Valencia J.,Muller J.,Vieira W.D.,Watabe H.,Shabanowitz J.,Hearing V.J.,Hunt D.F.,Appella E.
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
J. Proteome Res.
2
69-79
2003
523306
Chi A.,Valencia J.C.,Hu Z.-Z.,Watabe H.,Yamaguchi H.,Mangini N.J.,Huang H.,Canfield V.A.,Cheng K.C.,Yang F.,Abe R.,Yamagishi S.,Shabanowitz J.,Hearing V.J.,Wu C.,Appella E.,Hunt D.F.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
J. Proteome Res.
5
3135-3144
2006
523307
Liu J.P.,Liu N.S.,Yuan H.Y.,Guo Q.,Lu H.,Li Y.Y.
Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.
Mol. Cell. Biochem.
292
189-195
2006
523308
Royer-Zemmour B.,Ponsole-Lenfant M.,Gara H.,Roll P.,Leveque C.,Massacrier A.,Ferracci G.,Cillario J.,Robaglia-Schlupp A.,Vincentelli R.,Cau P.,Szepetowski P.
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Hum. Mol. Genet.
17
3617-3630
2008
523309
Ngcungcu T.,Oti M.,Sitek J.C.,Haukanes B.I.,Linghu B.,Bruccoleri R.,Stokowy T.,Oakeley E.J.,Yang F.,Zhu J.,Sultan M.,Schalkwijk J.,van Vlijmen-Willems I.M.J.J.,von der Lippe C.,Brunner H.G.,Ersland K.M.,Grayson W.,Buechmann-Moller S.,Sundnes O.,Nirmala N.,Morgan T.M.,van Bokhoven H.,Steen V.M.,Hull P.R.,Szustakowski J.,Staedtler F.,Zhou H.,Fiskerstrand T.,Ramsay M.
Duplicated enhancer region increases expression of CTSB and segregates with keratolytic winter erythema in South African and Norwegian families.
Am. J. Hum. Genet.
100
737-750
2017
523310
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
523311
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
523312
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
523313
Musil D.,Zucic D.,Turk D.,Engh R.A.,Mayr I.,Huber R.,Popovic T.,Turk V.,Towatari T.,Katunuma N.,Bode W.
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.
EMBO J.
10
2321-2330
1991
523314
Turk D.,Podobnik M.,Kuhelj R.,Dolinar M.,Turk V.
Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide.
FEBS Lett.
384
211-214
1996
523315
Podobnik M.,Kuhelj R.,Turk V.,Turk D.
Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen.
J. Mol. Biol.
271
774-788
1997