EC Number   |
Protein Variants |
Reference |
|---|
   7.2.2.2 | A910G |
mutants more sensitive to Cd2+ than wild type strain, higher activity for glutathione S-conjugated leukotriene C4 |
289190 |
| 7.2.2.2 | C476A |
the mutant enzyme binds 0.61 mol equiv of Co2+. The mutant enzyme shows about 4%, about 24%, and about 30% of Cd2+-, Co2+-, and Zn2+-stimulated ATP hydrolysis activity, respectively, compared to the wild type enzyme |
749922 |
| 7.2.2.2 | D398A |
non-phosphorylatable protein, no stimulation by Cd2+ but rather inhibition at high Cd2+ concentrations |
655547 |
| 7.2.2.2 | D777N |
mutants exhibit a Cd2+ hypersensitive phenotype, partially reduced transport activity for glutathione S-conjugated leukotriene C4 |
289190 |
| 7.2.2.2 | D777N |
strong defect in affinity for ATP and in transport velocity |
655838 |
| 7.2.2.2 | D777N/A1003V |
intragenic suppressor of mutation D777N |
655838 |
| 7.2.2.2 | D777N/A1021T |
intragenic suppressor of mutation D777N, functionally important residue |
655838 |
| 7.2.2.2 | D777N/A1021V |
intragenic suppressor of mutation D777N, functionally important residue |
655838 |
| 7.2.2.2 | D777N/F565L |
intragenic suppressor of mutation D777N, involved in determination of substrate specificity |
655838 |
| 7.2.2.2 | D777N/G1207D |
intragenic suppressor of mutation D777N, functionally important residue |
655838 |
