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Literature summary for 7.2.2.2 extracted from

  • Falcon-Perez, J.M.; Martinez-Burgos, M.; Molano, J.; Mazon, M.J.; Eraso, P.
    Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains (2001), J. Bacteriol., 183, 4761-4770.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.2

Protein Variants

Protein Variants Comment Organism
D777N strong defect in affinity for ATP and in transport velocity Saccharomyces cerevisiae
D777N/A1003V intragenic suppressor of mutation D777N Saccharomyces cerevisiae
D777N/A1021T intragenic suppressor of mutation D777N, functionally important residue Saccharomyces cerevisiae
D777N/A1021V intragenic suppressor of mutation D777N, functionally important residue Saccharomyces cerevisiae
D777N/F565L intragenic suppressor of mutation D777N, involved in determination of substrate specificity Saccharomyces cerevisiae
D777N/G1207D intragenic suppressor of mutation D777N, functionally important residue Saccharomyces cerevisiae
D777N/G1207S intragenic suppressor of mutation D777N, functionally important residue Saccharomyces cerevisiae
D777N/N1027D intragenic suppressor of mutation D777N Saccharomyces cerevisiae
D777N/Q1107R intragenic suppressor of mutation D777N, involved in determination of substrate specificity Saccharomyces cerevisiae
D777N/R1415G intragenic suppressor of mutation D777N, functionally important residue Saccharomyces cerevisiae
D777N/S1212L intragenic suppressor of mutation D777N, functionally important residue Saccharomyces cerevisiae
D777N/S674L intragenic suppressor of mutation D777N Saccharomyces cerevisiae
D777N/V543I intragenic suppressor of mutation D777N, involved in determination of substrate specificity Saccharomyces cerevisiae
D777N/W1225C intragenic suppressor of mutation D777N, involved in determination of substrate specificity Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 ATP pH 8.0, 30°C, wild-type Saccharomyces cerevisiae
1.06
-
 ATP pH 8.0, 30°C, mutant D777N/G1207D Saccharomyces cerevisiae
1.07
-
 ATP pH 8.0, 30°C, mutant D777N/Q1107R Saccharomyces cerevisiae
1.09
-
 ATP pH 8.0, 30°C, mutant D777N/V543I Saccharomyces cerevisiae
1.12
-
 ATP pH 8.0, 30°C, mutant D777N/G1207S Saccharomyces cerevisiae
1.14
-
 ATP pH 8.0, 30°C, mutant D777N/A1021T Saccharomyces cerevisiae
1.16
-
 ATP pH 8.0, 30°C, mutant D777N/N1027D Saccharomyces cerevisiae
1.37
-
 ATP pH 8.0, 30°C, mutant D777N/S674L Saccharomyces cerevisiae
1.39
-
 ATP pH 8.0, 30°C, mutant D777N/S1212L Saccharomyces cerevisiae
1.42
-
 ATP pH 8.0, 30°C, mutant D777N Saccharomyces cerevisiae
1.44
-
 ATP pH 8.0, 30°C, mutant D777N/F565L Saccharomyces cerevisiae
1.55
-
 ATP pH 8.0, 30°C, mutant D777N/A1003V Saccharomyces cerevisiae
1.65
-
 ATP pH 8.0, 30°C, mutant D777N/R1415G Saccharomyces cerevisiae
1.71
-
 ATP pH 8.0, 30°C, mutant D777N/A1021V Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cd2+/cytoplasm + ATP + H2O
-
 Saccharomyces cerevisiae Cd2+/vacuole + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Ycf1
-
 Saccharomyces cerevisiae