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EC Number
Protein Variants
Commentary
Reference
4.1.1.21
E177K
mutation identified in PAICS gene of AdeD cell, located in alpha4. Mutation impacts protein structure and completely abolishes its biosynthesis
728311
4.1.1.21
I237V
mutation identified in PAICS gene of AdeD cell, located in the loop between beta14 and alpha5
728311
4.1.1.21
T40N
the specific actzivity of the mutant is 20000fold lower than that of wild type enzyme
714253
4.1.1.21
W363?
mutation identified in PAICS gene of AdeD cell, located in alpha9. Mutation impacts protein structure and completely abolishes its biosynthesis
728311
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