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Information on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase

for references in articles please use BRENDA:EC4.1.1.21

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IUBMB Comments

While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase . 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
  • 4.1.1.21
  • saicars
  • n5-cair
  • phosphoribosylaminoimidazolesuccinocarboxamide
  • 4-carboxy-5-aminoimidazole
  • 6.3.2.6
  • aircs
  • n5-carboxyaminoimidazole
  • samdc
  • analysis

Synonyms
paics, phosphoribosylaminoimidazole carboxylase, air carboxylase, class ii pure, aminoimidazole ribonucleotide carboxylase, phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
inosine-5'-phosphate biosynthesis II
Highest Expressing Human Cell Lines
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